Xianghua Fu

ORCID: 0000-0002-8929-7669
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About
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Research Areas
  • Acute Myocardial Infarction Research
  • Coronary Interventions and Diagnostics
  • Cardiac Imaging and Diagnostics
  • Heart Failure Treatment and Management
  • Cardiovascular Function and Risk Factors
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Cardiac electrophysiology and arrhythmias
  • Cardiac Arrest and Resuscitation
  • Cardiac Ischemia and Reperfusion
  • Cardiac Arrhythmias and Treatments
  • Atrial Fibrillation Management and Outcomes
  • Cardiac pacing and defibrillation studies
  • Pulmonary Hypertension Research and Treatments
  • Venous Thromboembolism Diagnosis and Management
  • Thermoregulation and physiological responses
  • Renal and Vascular Pathologies
  • Chronic Kidney Disease and Diabetes
  • Climate Change and Health Impacts
  • Mechanical Circulatory Support Devices
  • Heart Rate Variability and Autonomic Control
  • Vascular Procedures and Complications
  • Ion channel regulation and function
  • Potassium and Related Disorders
  • Systemic Sclerosis and Related Diseases
  • Acupuncture Treatment Research Studies

Hebei Medical University
2014-2024

Second Hospital of Hebei Medical University
2014-2024

Peking University First Hospital
2018

Peking University
2018

Creative Commons
2018

Hebei Science and Technology Department
2014

GTx (United States)
2014

Bethune International Peace Hospital
2008

Few studies have explored the relationships between cold spells and acute myocardial infarction (AMI) using information of symptom onset.We assessed impact on AMI onset potential effect modifiers.We conducted a time-stratified case-crossover study among 456,051 eligible patients with from 2,054 hospitals in 323 Chinese cities January 2015 June 2021 during seasons (November to March). Nine definitions were used by combining three relative temperature thresholds (i.e., lower than 7.5th, 5th,...

10.1289/ehp11841 article EN public-domain Environmental Health Perspectives 2023-08-01

Abstract Objective To evaluate efficacy, safety and feasibility of targeted intracoronary injection using pro‐urokinase combined with anisodamine (TCA) versus thrombus aspiration (TA) in ST‐elevation myocardial infarction (STEMI) patients high loads. Background The best method avoiding detachment stroke PCI loads has not yet been established. Methods STEMI receiving coronary artery angiography or percutaneous intervention (CAG/PCI) grade ≥ 3 from January 1, 2017 to June 30, 2018 were...

10.1002/ccd.28112 article EN cc-by-nc-nd Catheterization and Cardiovascular Interventions 2019-02-15

Background Transradial approach catheterization is now widely used in coronary angiography and angioplasty. The ulnar artery, which one of the two terminal branches brachial may be a potential for cardiac catheterization. aim this study was to evaluate safety feasibility transulnar non-selective patients. Methods A total 535 consecutive patients were randomly assigned (TUA) group ( n =271) or transradial (TRA) =264) upon arrival at laboratory. Allen's test inverse not routinely performed....

10.3760/cma.j.issn.0366-6999.20132095 article EN cc-by-nc-nd Chinese Medical Journal 2014-04-05

To investigate the effect and medical cost of different revascularization strategies for acute myocardial infarction (AMI) patients with multi-vessel disease (MVD).A prospective randomized controlled trial (RCT) was conducted. From January 2009 to June 2012, AMI MVD undergoing primary percutaneous coronary intervention (PCI) were enrolled. They randomly assigned group A [staged PCI non-infarction related artery (non-IRA) within 7-10 days after AMI] B (subsequent non-IRA recommended only...

10.3760/cma.j.issn.2095-4352.2015.03.003 article EN PubMed 2015-03-01

In acute inferior myocardial infarction (AIMI), numerous conventional drugs that are used to improve the microcirculation can significantly reduce blood pressure (BP) and coronary perfusion pressure, aggravate bradyarrhythmia cause a deterioration in hemodynamic state of whole body, which greatly limits application these clinical settings. The aim present study was assess effect anisodamine nicorandil regimens on prevention no-reflow (NR) amelioration reperfusion patients with AIMI...

10.3892/etm.2015.2623 article EN Experimental and Therapeutic Medicine 2015-07-07

Successful ST-segment elevation myocardial infarction (STEMI) management is time-sensitive and based on prompt reperfusion mainly to reduce patient mortality. It has evolved from a single hospital care an integrated regional network approach over the last decades. This prospective study, named China STEMI Care Project (CSCAP), aims show how implementation of different types networks can improve treatment rate, shorten total duration ischaemia lead mortality reduction step by step.

10.1136/bmjopen-2018-026362 article EN cc-by-nc BMJ Open 2019-07-01

Aspirin and clopidogrel can improve myocardial reperfusion alleviate injury during percutaneous coronary intervention (PCI). Whether the addition of intravenous tirofiban this procedure produces further benefit has not been clarified in ST segment elevation infarction (STEMI) patients. We evaluated on STEMI patients who underwent primary PCI (p-PCI) via transradial artery approach.Consecutive were randomized into group (n=72) or placebo (n=78). Angiographic analysis included initial final...

10.1097/00029330-200803020-00011 article EN cc-by-nc-nd Chinese Medical Journal 2008-03-01

Many basic and clinical studies have proved that anisodamine can produce significant effect on relieving microvascular spasm, improving dredging the coronary microcirculation. It may be beneficial to improvement of slow-reflow phenomenon (SRP) following percutaneous intervention (PCI) for acute myocardial infarction (AMI). So we investigated intracoronary administration SRP infarct related artery (IRA) primary PCI in patients with ST segment elevated (STEAMI).Twenty-one from a total 148...

10.1097/00029330-200707020-00004 article EN cc-by-nc-nd Chinese Medical Journal 2007-07-01

Objective The aim of this study was to examine the role intracoronary anisodamine and diltiazem administration performed before stenting on immediate angiographic clinical outcome in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Methods STEMI during PCI were randomized two bolus injections (1 mg/5 ml) (2 (COM group, n=54) or saline (5 (diltiazem stenting. endpoint incidence no/slow reflow [thrombolysis (TIMI) flow...

10.1097/mca.0000000000000167 article EN Coronary Artery Disease 2014-09-17

Background: Several studies have demonstrated that primary percutaneous coronary intervention (PCI) can result in reperfusion injury. This study aims to investigate the effectiveness of liposomal prostaglandin E1 (Lipo-PGE1, Alprostadil, Beijing Tide Pharmaceutical Co., Ltd.) for enhancing microcirculation In addition, this determined optimal administration method acute ST elevation myocardial infarction (STEMI) patients undergoing PCI. Methods: Totally, 68 with STEMI were randomly assigned...

10.4103/0366-6999.156078 article EN cc-by-nc-nd Chinese Medical Journal 2015-05-05

To investigate the effects of levosimendan on right ventricular (RV) function in patients with acute decompensated heart failure (ADHF).Patients ADHF admitted from January 2017 to October were enrolled this study. The randomized receive 24-h intravenous or placebo. Echocardiographic examinations performed and parameters compared. Epidemiological data recorded compared before after treatment. Major adverse cardiac events during hospitalization 1-month follow-up compared.The baseline...

10.6515/acs.201911_35(6).20190327a article EN PubMed 2019-11-01

Prourokinase is a single-chain plasminogen activator presenting with fewer hemorrhagic complications and reduced reocclusion rate compared the conventional fibrinolytic agents in patients coronary artery disease. However, prourokinase intracoronary injection during PCI for treating ST-segment elevation myocardial infarction (STEMI) rarely investigated. Therefore, this study aimed to evaluate efficacy safety of percutaneous intervention (PCI) STEMI patients.Fifty who underwent primary were...

10.1186/s12872-020-01584-0 article EN cc-by BMC Cardiovascular Disorders 2020-06-26

The aim of this study was to evaluate the effects intracoronary administration anisodamine on myocardial reperfusion in patients with ST-segment elevation infarction (STEMI) undergoing a primary percutaneous coronary intervention (pPCI).Patients acute STEMI pPCI were enrolled randomized-controlled (January 2014-June 2015) and divided randomly into four groups: group A (normal saline), B (1000 μg anisodamine), C (2000 D (4000 anisodamine).The included 140 patients. Percentages thrombolysis...

10.1097/mca.0000000000000366 article EN Coronary Artery Disease 2016-03-05

Recent studies have revealed that pretreatment with statin is effective in preventing arrhythmia, but its electrophysiological mechanism unclear. This study was conducted to investigate the cardioprotective effects of simvastatin on reversing electrical remodeling left ventricular myocytes rabbit heart undergoing ischemia-reperfusion, so as explore ionic responsible for anti-arrhythmic effect statin.Forty-five rabbits were randomly divided into three groups: ischemic-reperfusion group (I-R),...

10.1097/00029330-200803020-00017 article EN cc-by-nc-nd Chinese Medical Journal 2008-03-01

To explore the optimal dosage of tirofiban associated with double benefits efficacy and safety in patients non-ST elevation acute coronary syndromes (NSTE-ACS) undergoing early percutaneous intervention (PCI).A total 163 were included this study (78 SD group versus 85 HD group). In (HD) group, was administered intravenously a bolus dose 10 (5) μg/kg within 3 min followed by continuous intravenous infusion 0.15 (0.075) μg/kg/min for 48 h. Within 24 h on admission, underwent CAG or CAG+PCI....

10.1111/1755-5922.12004 article EN Cardiovascular Therapeutics 2012-08-09
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