A5101417473- HIV Research and Treatment
- Web Data Mining and Analysis
- Regulation of Appetite and Obesity
- Functional Brain Connectivity Studies
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Digestive system and related health
- Neutropenia and Cancer Infections
- EEG and Brain-Computer Interfaces
- Cancer Research and Treatments
- Virus-based gene therapy research
- Respiratory Support and Mechanisms
- Drug Transport and Resistance Mechanisms
- Cancer-related Molecular Pathways
- Helminth infection and control
- Advanced Text Analysis Techniques
- Cognitive Computing and Networks
- Radio Wave Propagation Studies
- Cancer Diagnosis and Treatment
- Wireless Signal Modulation Classification
- Mosquito-borne diseases and control
Nanjing University
2005-2024
Yangpu Hospital of Tongji University
2019-2024
Tongji University
2016-2021
Beijing University of Technology
2009-2020
Shanghai Academy of Agricultural Sciences
2017
Suzhou Vocational University
2011
Tiangong University
2010
Nanjing General Hospital of Nanjing Military Command
2006-2007
Jinling Institute of Technology
2006
Nanjing Medical University
2005
Local alterations in the mechanical compliance of basement membrane that alter level isometric tension cell have been postulated to influence tissue morphogenesis. To explore whether contributes pattern formation vivo, we modulated cytoskeletal force generation embryonic mouse lung (embryonic days 12-14) rudiments using inhibitors Rho-associated kinase (ROCK), myosin light chain kinase, ATPase, and microfilament integrity, or a Rho stimulator (cytotoxic necrotizing factor-1). Tension...
Apoptosis plays a role in AIDS pathogenesis the immune system, but its HIV-1-induced neurological disease is unknown. In this study, we examine apoptosis induced by HIV-1 infection of central nervous system (CNS) an vitro model and brain tissue from patients. primary cultures neurons astrocytes as determined terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) propidium iodide staining electron microscopy. was not significantly until 1-2 wk after time peak virus...
ABSTRACT Apoptosis of neurons and astrocytes is induced by human immunodeficiency type 1 (HIV-1) infection in vitro has been demonstrated brain tissue from patients with AIDS. We analyzed a panel diverse HIV-1 primary isolates for the ability to replicate induce neuronal astrocyte apoptosis cultures. was three- eightfold blood-derived 89.6, SG3, ADA. In contrast, brain-derived YU2, JRFL, DS-br, RC-br, KJ-br did not significant levels apoptosis. The independent their replication capacity....
We report that human immunodeficiency virus type 1 (HIV-1) has evolved a self-perpetuating mechanism to actively generate cells permissive for productive and cytopathic infection. Only activated T can be productively infected, which leads their rapid depletion (2 × 10 9 /day in an infected individual). Establishment of HIV-1 infection therefore requires continual activations from the large pool quiescent cells. Tat protein, is secreted by cells, uninfected vitro vivo . These Tat-activated...
Human immunodeficiency virus type 1 (HIV-1) encodes a Vif protein which is important for replication and infectivity. cytoplasmic exists in both membrane-associated soluble forms. The form an extrinsic membrane tightly associated with the side of membranes. We have analyzed mechanism targeting its role HIV-1 replication. Mutagenesis studies demonstrate that C-terminal basic domains are required association. mutations disrupt association also inhibit replication, indicating localization...
Septic shock is the development of sepsis to refractory circulatory collapse and metabolic derangements, characterized by persistent hypotension increased lactate levels. Anisodamine hydrobromide (Ani HBr) a Chinese medicine used improve blood flow in disorders. The purpose this study was determine therapeutic efficacy Ani HBr treatment patients with septic shock.This prospective, multicenter, randomized controlled trial focusing on 16 hospitals China. Patients were randomly assigned 1:1...
Vehicle speed is a crucial input for mechanistic-based design and maintenance decision making of asphalt pavement. It can be measured using direct methods indirect methods. Direct methods, such as video camera inductive loops, have difficultly achieving real-time data processing sophisticated installation process. Indirect use the mechanical responses collected by traditional sensors to estimate speed. Although effective, these usually low survival rate require highly procedures. Recently,...
Introduction: Intestinal flora and the translocation of its products, such as muramyl dipeptide (MDP), are common causes sepsis. MDP is a activator intracellular pattern recognition receptor NOD2, can cause inflammatory damage to small intestine systemic responses in rats. Therefore, this study investigated effects on intestinal mucosa distant organs during sepsis role NOD2/AMPK/LC3 pathway MDP-induced mitochondrial dysfunction epithelium. Methods: Fifty male Sprague Dawley rats were...
Idiopathic pulmonary fibrosis (IPF) is an age-related disease featured with abnormal fibrotic response and compromised lung function. Cellular senescence now considered as essential driving mechanism for IPF. Given the poor knowledge of mechanisms underpinning IPF progression, understanding cellular processes molecular pathways critical developing effective therapies
SUMMARY The present investigation was undertaken to determine whether reserpine‐induced increase in the sulphation of small intestinal goblet cell mucins rats affects establishment helminths. When Wistar were given daily intraperitoneal injections reserpine for seven days and then implanted intraduodenally with 500 Strongyloides venezuelensis adult worms, number worms established intestine reserpine‐treated about half that controls. Furthermore, when mast cell‐deficient Ws/Ws treated...
SUMMARY Goblet and mast cell responses in the jejunum of four genera, Mesocricetus auratus (Syrian hamster), Phodopus campbelli, Cricetulus griseus (Chinese Tscherskia triton , belonging to subfamily Cricetinae, were examined after infection with Strongyloides venezuelensis . Parasite eggs became detectable faeces all genera on Day 7. Faecal egg count peaked around 8 C. T. 14 M. P. campbelli In faecal production persisted over 40 days, whereas that rapidly terminated within days. examined,...
High complexity, meaning a model in which components interact multiple ways and follow certain local rules, is huge challenge for brain research. This paper presents semantic vector-driven closed-loop model, namely THINKING-LOOP, computing to improve the understanding development of complex cognition. The proposed three-layer fusion data, information knowledge with human intelligence, exploits ontological modeling, rule-based reasoning human-computer interaction mechanism. collaboration...
The transcellular transport of muramyl dipeptide (MDP) mediated by peptide transporter (PepT1) involves the translocation into intestinal epithelial cell (IEC) stage and out IEC stage. However, its mechanism has not been fully understood. This study aimed to investigate pathways mechanisms MDP in enterogenous infection.Firstly, experimental rats were randomly divided three groups: sham-operation (sham group), perfusion (MDP PepT1 competitive inhibition + Gly-Gly group). Then, overall...