A5069567112- Fibroblast Growth Factor Research
- Glaucoma and retinal disorders
- RNA Interference and Gene Delivery
- Retinal and Macular Surgery
- Retinal Diseases and Treatments
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Intraocular Surgery and Lenses
- Kruppel-like factors research
- Intracerebral and Subarachnoid Hemorrhage Research
- MicroRNA in disease regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Microtubule and mitosis dynamics
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cholesterol and Lipid Metabolism
- Cancer-related molecular mechanisms research
- Radiopharmaceutical Chemistry and Applications
- ATP Synthase and ATPases Research
- Cancer Mechanisms and Therapy
- Neurosurgical Procedures and Complications
- Endometriosis Research and Treatment
- Advanced Drug Delivery Systems
Sichuan University
2015-2025
West China Hospital of Sichuan University
2024-2025
Second Xiangya Hospital of Central South University
2004-2024
Central South University
2003-2024
Hunan Provincial Center for Disease Control and Prevention
2022-2024
Affiliated Hospital of Southwest Medical University
2024
Analog Devices (United States)
2024
Surface Treatment Technologies (United States)
2024
Filtration Solutions (United States)
2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2014-2024
Quercetin, a dietary antioxidant present in fruits and vegetables, is promising cancer chemopreventive agent that inhibits tumor promotion by inducing cell cycle arrest promoting apoptotic death. In this study, we examined the biological activities of quercetin against gastric cancer. Our studies demonstrated exposure cells AGS MKN28 to resulted pronounced pro-apoptotic effect through activating mitochondria pathway. Meanwhile, treatment with induced appearance autophagic vacuoles, formation...
Intracerebral hemorrhage (ICH) induces potently oxidative stress responses and inflammatory processes. Isoliquiritigenin (ILG) is a flavonoid with chalcone structure can activate nuclear factor erythroid-2 related 2 (Nrf2)-mediated antioxidant system, negatively regulate factor-κB (NF-κB) nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome pathways, but its role potential molecular mechanisms in the pathology following ICH remain unclear. The present study aimed to...
The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome plays a key role in intracerebral hemorrhage (ICH)-induced inflammatory injury, and the purinergic 2X7 receptor (P2X7R) is upstream of NLRP3 activation. This study aimed to investigate how P2X7R functions ICH-induced injury interacts with inflammasome. Rats were treated small interfering RNA (siRNA) 24 h before undergoing collagenase-induced ICH. A selective inhibitor (blue brilliant G, BBG) or peroxynitrite (ONOO−) decomposition...
Breast carcinoma is the most common female cancer with considerable metastatic potential. Discovery of new therapeutic approaches for treatment breast still needed. Here, we reported our finding niclosamide, an FDA approved anthelmintic drug. The potency niclosamide on was assessed in vitro and vivo. In this investigation, found that showed a dramatic growth inhibition against cell lines induced apoptosis 4T1 cells dose-dependent manner. Further, Western blot analysis demonstrated occurrence...
Mitochondrial dysfunctions play a pivotal role in cerebral ischemia-reperfusion (I/R) injury. Although mitochondrial transplantation has been recently explored for the treatment of I/R injury, underlying mechanisms and fate transplanted mitochondria are still poorly understood.Mitochondrial morphology function were assessed by fluorescent staining, electron microscopy, JC-1, PCR, stress testing, metabolomics. Therapeutic effects evaluated cell viability, reactive oxygen species (ROS),...
Intracerebral hemorrhage (ICH) can induce intensively oxidative stress, neuroinflammation, and brain cell apoptosis. However, currently, there is no highly effective treatment available. Puerarin (PUE) possesses excellent neuroprotective effects by suppressing the NF-κB pathway activating PI3K/Akt signal, but its role related mechanisms in ICH-induced early injury (EBI) remain unclear. In this study, we intended to observe of PUE molecular on EBI. ICH was induced rats collagenase IV...
In our investigation, we aimed to shed light on the role of senescent cells in renal fibrosis, considering observed correlation between tubular epithelial cell senescence and presence fibrosis. Our findings confirm manifestation characteristics during fibrosis establish their capacity trigger a transition from macrophages myofibroblasts, known as macrophage-myofibroblast (MMT). Additionally, study uncovered that extracellular vesicles released by HK-2 (sHK-2) play pivotal facilitating MMT....
Matching ABO blood group antigens between donors and recipients is critical to prevent hyperacute rejection in kidney transplantation. Enzymatic conversion of the universal O type presents a promising strategy overcome barriers ABO-incompatible In this study, we employ α-galactosidase from Bacteroides fragilis convert B kidneys during hypothermic machine perfusion. After 3 hours perfusion with enzyme, more than 95% endothelium are effectively removed. Subsequently, enzyme-treated protected...
Hepatitis B virus (HBV) infection has been shown by certain studies to be associated with diabetes mellitus (DM); however, the results of these were controversial. For that reason, a meta-analysis literature was performed in order determine association between HBV and prevalence DM more accurately. The PubMed, Embase, Chinese National Knowledge Infrastructure Wan Fang databases, as well Science Technology Journal Database, searched for published until June 2014. reference lists all relevant...
Background: AZD4547, a small-molecule inhibitor targeting the tyrosine kinase of Fibroblast Growth Factor Receptors (FGFRs), is currently under phase II clinical study for human subjects having breast cancer, while underlying mechanism remains elusive. The aim this to explore potential by which AZD4547 inhibits tumor lung metastases at level microenvironment. Methods: First, through in vitro experiments, we investigated efficacy FGFRs on 4T1 cells their proliferation, apoptosis, migration,...
Epithelial-mesenchymal transition (EMT) is a vital process in epithelial cancer invasion and metastasis. The induction of EMT by Six1 has been described as common mode progression, which could promote breast migration invasion. In the study, we found that miR-204-5p suppress cell lines. Since overexpression EMT, identified mechanism inhibited downregulating Six1, was mediated conserved seed-matching sequence 3'-UTR mRNA. We also upregulation downregulate expression, affecting conclusion,...
G-protein-coupled receptor 48 (GPR48) is an orphan belonging to the receptors family, which plays important role in development of various organs and cancer progression such as gastric colorectal (CRC). However, prognostic value GPR48 expression patients with CRC has not been reported. In this study, we observed that was overexpressed primary metastatic lymph nodes closely correlated tumor invasion metastasis. Multivariate analysis indicated high a poor factor for overall survival patients....
A rational combination is critical to achieve efficiently synergistic therapeutic efficacy for tumor treatment. Hence, we designed novel antitumor combinations (T-NPs) by integrating the vascular and cells dual-targeting ligand with antiangiogenesis/antitumor agents. The truncated bFGF peptide (tbFGF), which could effectively bind FGFR1 overexpressed on neovasculature endothelial cells, was selected modify PLGA nanoparticles (D/P-NPs) simultaneously loaded PEDF gene paclitaxel in this study....
The aim of this study was to demonstrate the surgical technique and clinical outcome autologous neurosensory retinal patch transplantation for recurrent large macular hole (MH)-induced detachment after failed surgery with internal limiting membrane (ILM) removal or transplantation.We reviewed 5 patients MH-induced surgeries ILM who underwent vitrectomy combined transplantations were followed up over 6 months. In procedure, a small piece retina removed transplanted inside MH. anatomic...
Gastric cancer (GC) is a common life‑threatening type worldwide, with an increasing prevalence and high rate of mortality. Due to limitations in clinical treatment, surgery has become the most efficient strategy for treatment GC. It urgent identify novel biomarkers, which are useful diagnosis GC improving survival patients HDACs multi‑functional proteins involved regulating gene expression, cell proliferation epigenetic regulation. However, precise role progression remains unknown. The...