A5026142690- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- RNA regulation and disease
- Extracellular vesicles in disease
- Intracerebral and Subarachnoid Hemorrhage Research
- Memory and Neural Mechanisms
- Apelin-related biomedical research
- Immune Response and Inflammation
- Immune cells in cancer
- Geotechnical Engineering and Underground Structures
- Plant Reproductive Biology
- Cancer Immunotherapy and Biomarkers
- Hydrogen's biological and therapeutic effects
- Galectins and Cancer Biology
- Microplastics and Plastic Pollution
- Rock Mechanics and Modeling
- Anesthesia and Neurotoxicity Research
- Metabolism and Genetic Disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Grouting, Rheology, and Soil Mechanics
- CNS Lymphoma Diagnosis and Treatment
- Geotechnical Engineering and Analysis
Guiyang Medical University
2024-2025
Huashan Hospital
2020-2024
Fudan University
2020-2024
Mitochondrial dysfunctions play a pivotal role in cerebral ischemia-reperfusion (I/R) injury. Although mitochondrial transplantation has been recently explored for the treatment of I/R injury, underlying mechanisms and fate transplanted mitochondria are still poorly understood.Mitochondrial morphology function were assessed by fluorescent staining, electron microscopy, JC-1, PCR, stress testing, metabolomics. Therapeutic effects evaluated cell viability, reactive oxygen species (ROS),...
Engineered extracellular vesicles (EVs) are considered excellent delivery vehicles for a variety of therapeutic agents, including nucleic acids, proteins, drugs, and nanomaterials. Recently, several studies have indicated that clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) delivered by EVs enable efficient DNA editing. However, an RNA editing tool is still unavailable. Here, signal peptide-optimized EVs-delivered guide (gRNA) CRISPR/CasRx...
Polystyrene nanoparticles (PS-NPs) are organic pollutants that widely detected in the environment and organisms, posing potential threats to both ecosystems human health. PS-NPs have been proven penetrate blood-brain barrier increase incidence of neurodegenerative diseases. However, information relating pathogenic molecular mechanism is still unclear. This study investigated neurotoxicity regulatory mechanisms neuroblastoma SHSY-5Y cells. The results show caused obvious mitochondrial...
ABSTRACT Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease (AID) mediated by myelin‐reactive CD4 + T cells. Experimental encephalomyelitis (EAE) widely used animal model of human MS. Erythrocyte membrane‐associated protein (ERMAP) novel erythrocyte‐specific adhesion/receptor molecule associated with erythrocyte adhesion. We have previously characterised it as inhibitory immune checkpoint and demonstrated that recombinant ERMAP proteins ameliorate EAE; however, the...
The rockburst phenomenon occurs in dry red sandstone under high situ stress, and the effect is weaker for a water-bearing rock. on with different water contents analyzed this paper. A true triaxial testing machine used to conduct loading, acoustic emission recording equipment high-speed camera are monitor signal inside rock rock-caving situation throughout entire process order analyze characteristics of emissions ejection form rockburst. results show that 50% saturated but not sandstone....
Abstract Background Intracerebral hemorrhage (ICH) is a devastating neurological disease causing severe sensorimotor dysfunction and cognitive decline, yet there no effective treatment strategy to alleviate outcomes of these patients. The Mas axis-mediated neuroprotection involved in the pathology various diseases, however, role receptor setting ICH remains be elucidated. Methods C57BL/6 mice were used establish model by injection collagenase into striatum. agonist AVE0991 was administered...
Stem cells offer a promising therapeutic strategy for patients with disorders of consciousness (DOC) after severe traumatic brain injury (TBI), but the optimal transplantation sites and are not clear. Although paraventricular thalamus (PVT) claustrum (CLA) associated candidate targets, few studies have been designed to investigate this possibility.
Objective To our knowledge, the impact of area-level socioeconomic status (SES) has not yet been described in primary central nervous system lymphomas (PCNSLs). Current study sought to explore association deprivation, measured using Area Deprivation Index (ADI), with PCNSL outcomes. Methods The Surveillance, Epidemiology, and End Results (SEER) database was used identify patients diagnosed between 2006 2015 for analyses. ADI on overall survival (OS) cancer-specific (CSS) were investigated....
Several engineering practices have shown that the excavation of shallow-buried tunnels beneath major roads, as well selection appropriate measures and construction methods, has a significant impact on road surface settlement. Therefore, field monitoring numerical simulation are adopted in this study to analyze effect cross diaphragm (CRD) method settlement for under-construction Yüan 1 railroad tunnel. The findings show during four divisions CRD tunnels, amount caused by part accounts 40%...
Traumatic brain injury (TBI), especially moderate or severe TBI, is one of the most devastating injuries to nervous system, as existing therapies for neurological defect repair have difficulty achieving satisfactory results. Neural stem cells (NSCs) therapy a potentially effective treatment option, after specific genetic modifications and when used in combination with biomimetic biological scaffolds. In this study, tussah silk fibroin (TSF) scaffolds interconnected nanofibrous structures...
<title>Abstract</title> The B7 family of immune checkpoints, particularly PD-L1 and PD-1, has revolutionized immunotherapy; however, identifying novel checkpoint molecules remains essential. In this study, we discovered that VSIG2 functions as an immunosuppressive ligand, with high expression levels in activated antigen-presenting cells. Notably, does not bind to known co-stimulatory or co-inhibitory receptors such CD28, BTLA, CTLA-4, ICOS, VISTA. Previous research suggests may play a role...
Abstract Background: Ischemic stroke results in high morbidity and mortality, mitochondrial dysfunctions play a crucial role the associated pathological process. Although exogenous mitochondria were used to treat ischemic stroke-induced brain injury, its effects related mechanisms remain poorly understood, as is fate of during/after internalization by targeted cells. Methods: The morphology, membrane potential, DNA copy number, stress, metabolic characteristics tumorigenicity mNSCs Neuro-2a...
Abstract Background: Ischemic stroke results in high morbidity and mortality, mitochondrial dysfunctions play a crucial role the associated pathological process. Although exogenous mitochondria were used to treat ischemic stroke-induced brain injury, its effects related mechanisms remain poorly understood, as is fate of during/after internalization by targeted cells. Methods: The morphology, membrane potential, DNA copy number, stress, metabolic characteristics tumorigenicity mNSCs Neuro-2a...
The B7-CD28 gene family plays a crucial role in modulating immune functions and has served as potential targets for immunotherapeutic strategies. Therefore, we systematically analyzed expression profiles constructed family-based prognostic signature to predict survival host status diffuse gliomas. TCGA dataset was used training cohort, three CGGA datasets (mRNAseq_325, mRNAseq_693 mRNA-array) were employed validation cohorts intensify the findings that have revealed dataset. Ultimately,...