A5100380567- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Olfactory and Sensory Function Studies
- Pain Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Neurobiology and Insect Physiology Research
- Neuroendocrine regulation and behavior
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Sleep and Wakefulness Research
- Human Pose and Action Recognition
- Axon Guidance and Neuronal Signaling
- Biochemical Analysis and Sensing Techniques
- Photoreceptor and optogenetics research
- Ion channel regulation and function
- Ion Channels and Receptors
- Cellular transport and secretion
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Transcranial Magnetic Stimulation Studies
- Nicotinic Acetylcholine Receptors Study
- EEG and Brain-Computer Interfaces
- Advanced Vision and Imaging
- Neuroscience and Neural Engineering
Shanghai Jiao Tong University
2021-2025
Ruijin Hospital
2024-2025
Shenyang Pharmaceutical University
2023-2025
Shanghai Mental Health Center
2021-2024
Massachusetts Institute of Technology
2018-2024
McGovern Institute for Brain Research
2021-2024
Shanghai Hospital Development Center
2024
Sichuan Agricultural University
2023-2024
Kunming University of Science and Technology
2023-2024
Nanjing University of Chinese Medicine
2024
We have developed a genetic approach to visualize axons from olfactory sensory neurons expressing given odorant receptor, as they project the bulb. Neurons specific receptor only two topographically fixed loci among 1800 glomeruli in mouse Our data provide direct support for model which topographic map of activation encodes odor quality Receptor swap experiments suggest that plays an instructive role guidance process but cannot be sole determinant establishment this map. This may more...
Olfactory neurons expressing a given odorant receptor project with precision to 2 of the 1800 glomeruli within olfactory bulb create topographic map odor quality. We demonstrate that deletions or nonsense mutations in P2 gene cause axons these cells wander rather than converge on specific glomerulus. Receptor substitution experiments replace coding region P3 result projection P3-->P2 glomerulus touching wild-type These data, along additional substitutions, indicate plays an instructive role...
Abstract Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and circuit mechanisms underlying ASDs remain elusive. Here, we describe a complete knockout mouse model of autism-associated Shank3 gene, with deletion exons 4–22 (Δe4–22). Both mGluR5-Homer scaffolds mGluR5-mediated signalling are selectively altered striatal neurons. These changes associated perturbed function at synapses,...
Human acute and inflammatory pain requires the expression of voltage-gated sodium channel Nav1.7 but its significance for neuropathic is unknown. Here we show that in different sets mouse sensory sympathetic neurons underlies distinct types sensation. Ablating gene (SCN9A) all using Advillin-Cre abolishes mechanical pain, reflex withdrawal responses to heat. In contrast, heat-evoked retained when SCN9A deleted only Nav1.8-positive nociceptors. Surprisingly, hotplate test, as well are...
Normal hearing depends on the ability to distinguish self-generated sounds from other sounds, and this is thought involve neural circuits that convey copies of motor command signals various levels auditory system. Although such interactions at cortical level are believed facilitate comprehension during movements drive hallucinations in pathological states, synaptic organization function circuitry linking cortices remain unclear. Here we describe experiments mouse characterize well suited...
Background: Depression is a mental disorder that poses serious threat to human health.Adult hippocampal neurogenesis (AHN) closely associated with the efficacy of antidepressants.Chronic treatment corticosterone (CORT), well-validated pharmacological stressor, induces depressive-like behaviors and suppresses AHN in experimental animals.However, possible mechanisms chronic CORT action remain elusive.Methods: A (0.1 mg/mL, drinking water for 4 weeks) was applied prepare mouse model...
Phonation critically depends on precise controls of laryngeal muscles in coordination with ongoing respiration. However, the neural mechanisms governing these processes remain unclear. We identified excitatory vocalization-specific premotor neurons located retroambiguus nucleus (RAm VOC ) adult mice as being both necessary and sufficient for driving vocal cord closure eliciting mouse ultrasonic vocalizations (USVs). The duration RAm activation can determine lengths USV syllables concurrent...
Olfactory sensory neurons expressing a given odorant receptor project to two topographically fixed glomeruli in the olfactory bulb. We have examined contribution of different cell types bulb establishment this topographic map. Mice with homozygous deficiency Tbr-1 lack most projection neurons, whereas mice Dlx-1 and Dlx-2 GABAergic interneurons. bearing P2-IRES-tau-lacZ allele deficient either or Dlx-1/Dlx-2 reveal convergence axons one medial lateral site at positions analogous those...
The lipid kinase PIK3C3 (also called Vps34) regulates both the endosomal and autophagic pathways. However, effect of inactivating on neuronal versus processes in vivo has not been studied. We generated mice which Pik3c3 was conditionally deleted differentiated sensory neurons. Within a few days after deletion, mutant large-diameter myelinated neurons accumulated numerous enlarged vacuoles ubiquitin-positive aggregates underwent rapid degeneration. By contrast, -deficient small-diameter...
Unlike neurons in the central nervous system (CNS), injured peripheral (PNS) can regenerate their axons and reinnervate targets. However, functional recovery PNS often remains suboptimal, especially cases of severe damage. The lack regenerative ability CNS has been linked to down-regulation mTOR (mammalian target rapamycin) pathway. We report here that dorsal root ganglial (DRGs) activate following damage this activity enhances axonal growth capacity. Furthermore, genetic up-regulation by...
Synthesis of phosphatidylinositol-3-phosphate (PI3P) by Vps34, a class III phosphatidylinositol 3-kinase (PI3K), is critical for the initial steps autophagosome (AP) biogenesis. Although Vps34 sole source PI3P in budding yeast, mammalian cells can produce through alternate pathways, including direct synthesis II PI3Ks; however, physiological relevance these pathways context autophagy unknown. Here we generated knockout mouse embryonic fibroblasts (MEFs) and using higher affinity 4x-FYVE...