A5088603806- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Neurogenesis and neuroplasticity mechanisms
- Cervical and Thoracic Myelopathy
- Nerve injury and regeneration
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic and Acetabular Injuries
- Shoulder Injury and Treatment
- Infectious Diseases and Tuberculosis
- Anesthesia and Pain Management
- Pharmaceutical Practices and Patient Outcomes
- Spinal Cord Injury Research
- Axon Guidance and Neuronal Signaling
- Spinal Dysraphism and Malformations
- Venous Thromboembolism Diagnosis and Management
- Pluripotent Stem Cells Research
- Spinal Hematomas and Complications
- Spondyloarthritis Studies and Treatments
- Mesenchymal stem cell research
- Vascular Malformations Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- PARP inhibition in cancer therapy
- Case Reports on Hematomas
Fujita Health University
2020-2025
Fujita Health University Hospital
2020-2023
Murayama Medical Center
2012-2022
National Hospital Organization
2012-2022
Keio University
1981-2014
Keio University Hospital
2007-2014
Harvard University
2005-2007
Boston Children's Hospital
2005-2007
Oita Medical Center
2005
Harvard University Press
2005
The lipid kinase PIK3C3 (also called Vps34) regulates both the endosomal and autophagic pathways. However, effect of inactivating on neuronal versus processes in vivo has not been studied. We generated mice which Pik3c3 was conditionally deleted differentiated sensory neurons. Within a few days after deletion, mutant large-diameter myelinated neurons accumulated numerous enlarged vacuoles ubiquitin-positive aggregates underwent rapid degeneration. By contrast, -deficient small-diameter...
Axonal damage is a major morphological alteration in the CNS of patients with multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). However, underlying mechanism for axonal associated MS/EAE contribution to clinical symptoms remain unclear. The expression fusion protein, named "Wallerian degeneration slow" (Wld(S)), can protect axons from degeneration, likely through beta-nicotinamide adenine dinucleotide (NAD)-dependent mechanism. In this study, we...
Transplantation of glial-rich neural progenitors has been demonstrated to attenuate motor neuron degeneration and disease progression in rodent models mutant superoxide dismutase 1 (SOD1)-mediated amyotrophic lateral sclerosis (ALS). However, translation these results into a clinical setting requires renewable human cell source. Here, we derived from iPSCs transplanted them the lumbar spinal cord ALS mouse models. The cells differentiated astrocytes, treated group showed prolonged lifespan....
In Brief Study Design. Retrospective, observational study. Objective. To assess the efficacy and safety of tranexamic acid (TXA) in decreasing operative blood loss need for transfusion during posterior spinal fusion treatment idiopathic scoliosis adolescents. Summary Background Data. Blood associated with surgery is a common potential cause morbidity often requires transfusion, which subjects patients to known risks including transmission diseases. Since 1990s, intraoperative administration...
A retrospective, multicenter study.To investigate the relationship between postoperative shoulder balance and adding-on in Lenke type 2 adolescent idiopathic scoliosis.Postoperative imbalance (PSI) are main complications occurring at proximal to upper instrumented vertebra distal lower instrumental (LIV), respectively. Inadequate selection of LIV selective thoracic fusion surgery may result adding-on. It remains unclear whether is associated with adding-on.Preoperative, postoperative, 2-year...
In Brief Study Design. A retrospective, observational, and multicenter study. Objective. To identify the ideal lower instrumented vertebra (LIV) to prevent distal adding-on after surgical correction of Lenke type 2A curve. Summary Background Data. LIV level may affect risk postsurgical adding-on. The choice last touching (LTV)—the most caudal main thoracic curve that touches central sacral vertical line when standing—as an appropriate has been validated for 1A but not Methods. Radiographs...
White matter abnormalities in the CNS have been reported recently various neurological and psychiatric disorders. Quantitation of non-Gaussianity for water diffusion by q -space diffusional MRI (QSI) renders biological barriers such as myelin sheaths; however, time-consuming nature this method hinders its clinical application. In current study, we aimed to refine QSI protocols enable their application visualize signals a setting. For purpose, animal studies were first performed optimize...
Rats exhibit extremely limited motor function recovery after total transection of the spinal cord (SCT). We previously reported that SM-216289, a semaphorin3A inhibitor, enhanced axon regeneration and in SCT adult rats. However, these effects were because most regenerated axons likely do not connect to right targets. Thus, rebuilding appropriate connections for may enhance recovery. In this study, we combined inhibitor treatment with extensive treadmill training determine whether would...
Study Design. A prospective case series. Objective. The aim of this study was to compare the standing balance and posture between patients with adult spinal deformity (ASD) healthy volunteers (HVs). Summary Background Data. effect ASD on has not been fully documented. Methods. Forty consecutive female (65.4 ± 6.7 yrs, Cobb angle 48.6 20.2°, C7PL 9.1 6.4 cm, PI-LL 41.1 25.2°) 33 matched HV (72.4 4.6 yrs) were included. We reviewed charts x-rays from ASDs categorized as having a mismatch that...
At present, the threshold defining older adults is 65 years, and this classification has been widely accepted globally. However, with extension of both life expectancy healthy expectancy, there a need to reconsider age-based definition. This study compared characteristics surgical outcomes patients lumbar spinal stenosis (LSS) between early late stages clarify age diversity in population. Data collected from consecutive aged ≥ years who underwent LSS surgery were retrospectively reviewed....
Abstract Background Fractures are a significant health concern for older adults, affecting their activities of daily living (ADL), physical function, and mental well-being, contributing to the need long-term care. However, factors associated with fractures among independent adults remain unclear. This study aimed examine association between status in representative suburban city Japan using data from survey community-dwelling residents identify fractures. Methods A total 15,853...
Abstract Background Various treatments for chronic low back pain (LBP) have been reported; among them, platelet‐rich plasma (PRP) as a regenerative medicine has attracted much attention. Although Modic type 1 change (MC1) is associated with LBP, no treatment established so far. In addition, studies administered PRP to intervertebral discs (IVDs) in patients targeting MC1 only. Thus, the purpose of this study was determine safety and efficacy administration IVDs experiencing LBP. Methods...
Polypharmacy is a growing public health problem occurring in all healthcare settings worldwide. Elderly patients with lumbar spinal canal stenosis (LSS) who manifest low back and neuropathic pain have high frequency of comorbidity are predicted to take many drugs. However, no studies reported polypharmacy elderly LSS. Thus, we aimed review the among LSS elective surgeries examine how surgical treatment reduces polypharmacy.We retrospectively enrolled aged ≥ 65 years underwent surgery for...
Study Design. A retrospective observational study. Objective. This study examined the role of skeletal muscles in spinal alignment lumbar degenerative kyphosis (LDK). Summary Background Data. Adult deformity (ASD) may present as LDK, which is unusual that it typically lacks any coronal deformity. Methods. included 367 female patients with ASD. Demographic and radiographic data from LDKs were compared those other The LDK multifidus was also subjected to histological analysis. muscle volume...
A new concept of device, termed the weight-bearing control (WBC) orthosis, has been designed with three major needs in mind; a rigid frame that supports user's body weight, special hip joint device reciprocally propels each leg forward, gas powered foot varies sole thickness for foot/floor clearance, and system orthosis. paraplegic (T7 level complete paraplegia, sensory evoked potential silent, response to electro-stimulation on cortical area brain also silent) who tested this WBC orthosis...
Study Design: A prospective observational study. Objective: To evaluate whether scoliosis is a risk factor for gastroesophageal reflux disease (GERD) in elderly patients. Summary of Background Data: Sagittal spinal deformities are reported to cause GERD, but its association with deformity the coronal plane not well studied. Methods: We examined 190 patients disorders (mean age 70.6±8.6 y) who underwent standing whole-spine x-rays and sagittal planes. GERD symptoms were assessed by Quest...
Oxidative stress (OS) results in many disorders, of which degenerative musculoskeletal conditions are no exception. However, the interaction between OS and ligamentum flavum (LF) hypertrophy lumbar spinal canal stenosis is not clearly understood. The first research question was whether involved LF hypertrophy, second antioxidant N-acetylcysteine (NAC) effective on hypertrophy. In total, 47 samples were collected from patients with disorders. cross-sectional area measured axial magnetic...