A5065469714- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Connective tissue disorders research
- Medical Imaging and Analysis
- Bone health and osteoporosis research
- Dental Implant Techniques and Outcomes
- Congenital heart defects research
- Pelvic and Acetabular Injuries
- Hip disorders and treatments
- Bone Metabolism and Diseases
- Parkinson's Disease and Spinal Disorders
- Cervical and Thoracic Myelopathy
- Genetic factors in colorectal cancer
- Spinal Dysraphism and Malformations
- Chemical Synthesis and Characterization
- Neurogenetic and Muscular Disorders Research
- Craniofacial Disorders and Treatments
- Orthopedic Infections and Treatments
- Musculoskeletal pain and rehabilitation
- Neurological disorders and treatments
- Bone and Joint Diseases
- Spondyloarthritis Studies and Treatments
Katsumata Hospital
2024
Juntendo University
2012-2021
Juntendo University Hospital
2004-2017
Creative Commons
2017
Christie's
2017
RIKEN Center for Integrative Medical Sciences
2017
Meijo Hospital
2012-2013
Abstract The aging process correlates with the accumulation of cellular and tissue damage caused by oxidative stress. Although previous studies have suggested that stress plays a pathologic role in development bone fragility, little direct evidence has been found. In order to investigate significance bones, we analyzed mice deficient cytoplasmic copper/zinc superoxide dismutase (CuZn-SOD, encoded Sod1 gene; Sod1−/−). this study, showed for first time vivo distinct weakness stiffness...
Abstract Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays strong female bias. By performing genome-wide association study (GWAS) of 3,102 individuals, we identify significant associations with 20p11.22 SNPs for females ( P =6.89 × 10 −9 ) but not males =0.71). This IS also found in independent cohorts from the United States America and Japan (overall =2.15 −10 , OR=1.30 (rs6137473)). Unexpectedly, risk alleles were previously associated protection...
A retrospective, multicenter study.To investigate the relationship between postoperative shoulder balance and adding-on in Lenke type 2 adolescent idiopathic scoliosis.Postoperative imbalance (PSI) are main complications occurring at proximal to upper instrumented vertebra distal lower instrumental (LIV), respectively. Inadequate selection of LIV selective thoracic fusion surgery may result adding-on. It remains unclear whether is associated with adding-on.Preoperative, postoperative, 2-year...
Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity, affecting around 2% of adolescents worldwide. Genetic factors play an important role in its etiology. Using a genome-wide association study (GWAS), we recently identified novel AIS susceptibility loci on chromosomes 10q24.31 and 6q24.1. To identify more relating to severity progression, performed GWAS by limiting case subjects those with severe AIS. Through two-stage using total ∼12,000 Japanese subjects, variant,...
In Brief Study Design. A retrospective, observational, and multicenter study. Objective. To identify the ideal lower instrumented vertebra (LIV) to prevent distal adding-on after surgical correction of Lenke type 2A curve. Summary Background Data. LIV level may affect risk postsurgical adding-on. The choice last touching (LTV)—the most caudal main thoracic curve that touches central sacral vertical line when standing—as an appropriate has been validated for 1A but not Methods. Radiographs...
In addition to genetic factors, environmental and lifestyle factors are thought play an important role in the onset of adolescent idiopathic scoliosis (AIS). This cross-sectional study was conducted explore related AIS.This included 2,759 Japanese female junior high school students who planned a secondary screening after initial moiré topography indicated possible scoliosis. The their mothers, or guardians, were asked fill out questionnaire consisting 38 questions about demographic...
Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them locus on chromosome 6q24.1 that we by GWAS in Japanese cohort. The represented rs6570507 located within GPR126. To ensure AIS, conducted meta-analysis using eight cohorts from East Asia, Northern Europe USA. analysis included total 6,873 cases 38,916 controls...
A prospective study of magnetic resonance imaging findings in outpatients with idiopathic scoliosis.The purpose this was to determine the prevalence neural axis abnormalities scoliosis and analyze characteristics patients who had such abnormalities.In previous studies, were found 2.9% 37% scoliosis. The current guidelines for MRI screening are valuable, proposed indications performing literature include early onset, atypical curvature, double thoracic curve (King type-5), rapid progression,...
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity affecting millions of children. Since treatment and prognosis AIS depend on curve progression, identifying factors related to progression important in its management. Although several genetic loci for occurrence are reported, no locus has been identified. To identify genes associated with we conducted genome-wide association study followed by replication using total 2,543 subjects who were evaluated the progression. We...
In Brief Study Design. A genetic association study of single nucleotide polymorphisms (SNPs) previously reported to be associated with curve progression adolescent idiopathic scoliosis (AIS). Objective. To determine whether the 53 SNPs in white patients AIS are replicated Japanese AIS. Summary Background Data. Predicting is important clinical practice The a number genes. Associations have been reported, and used for test AIS; however, there has no replication their association. Methods. We...
Abstract Background Congenital scoliosis (CS) is defined as a lateral curvature of the spine due to vertebral malformations and has an incidence 0.5–1/1,000 births. We previously examined TBX6 in Japanese CS patients revealed that approximately 10% was caused by mutations. However, genetic cause remaining unknown. Methods recruited 78 without mutations major comorbidities, investigated genes reported be associated with congenital whole‐exome sequencing. Results identified compound...
A genetic association study of single nucleotide polymorphisms (SNPs) previously reported to be associated with curve progression adolescent idiopathic scoliosis (AIS).To determine whether the 5 SNPs in Chinese AIS are replicated Japanese patients AIS.AIS is a common spinal deformity and has strong predisposition. Predicting important clinical practice. The number genes. Associations neurotrophin 3, G protein-coupled estrogen receptor, tissue inhibitor metalloproteinase 2 have been Han AIS;...
A retrospective investigation of the retrodental mass secondary to rheumatoid arthritis (RA).To propose a new classification in RA, and evaluate their resorption processes surgical procedures.The RA has long been recognized as pannus formation. It is also known that will disappear or radically reduce after stabilization atlantoaxial segment. The past reports, however, leave unanswered following question; are there other types with significantly different degeneration from pannus? need for...
Congenital scoliosis (CS) is a common vertebral malformation. Spondylocostal dysostosis (SCD) rare skeletal dysplasia characterised by multiple malformations and rib anomalies. In previous study, compound heterozygosity for null mutation risk haplotype composed three single-nucleotide polymorphisms in TBX6 have been reported as disease-causing model of CS. Another study identified bi-allelic missense variants SCD patient. The purpose our to identify CS examine their pathogenicity.We...
This research aimed to mechanically analyze vertebral stress concentration in one healthy subject and with osteoporotic first lumbar (L1) compression fracture by using finite element analysis (FEA). We constructed three-dimensional image-based (FE) models (Th12L2) computed tomographic (CT) digital imaging communications medicine (DICOM) for each patient then conducted exercise simulations on the spine models. The loadings 12th thoracic vertebra (Th12) due compression, flexion, extension,...
The aim of this work is to assess the biomechanical response or load transfer response between osteoporotic (with first lumbar (L1) vertebral compression fracture) and healthy vertebrae in five physiological motions namely as compression, flexion, extension, lateral bending axial rotation. For purpose, an image-basedheterogeneous three-dimensional patient-specific thoracic spinal unit (T12-L2) finite element models for healthy and osteoporotic subjects were created. The analysis...