A5034959960- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Connective tissue disorders research
- Musculoskeletal pain and rehabilitation
- Genetic factors in colorectal cancer
- Pelvic and Acetabular Injuries
- Congenital heart defects research
- Anesthesia and Pain Management
- Spinal Dysraphism and Malformations
- Medical Imaging and Analysis
- Congenital Diaphragmatic Hernia Studies
- Pain Management and Opioid Use
- Hip disorders and treatments
- Opioid Use Disorder Treatment
- Cancer-related molecular mechanisms research
- Pediatric Hepatobiliary Diseases and Treatments
- Diet and metabolism studies
- Tuberous Sclerosis Complex Research
- Cervical and Thoracic Myelopathy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Pregnancy-related medical research
- Neurological and metabolic disorders
- Blood transfusion and management
Keio University
2014-2024
Tachikawa Hospital
2022-2024
Norton Healthcare
2019-2022
Shizuoka Red Cross Hospital
2017-2021
University of Louisville
2020
Keio University Hospital
2019
RIKEN Center for Integrative Medical Sciences
2012-2018
National Hospital Organization
2006
Tokyo Medical Center
2006
Okayama Rosai Hospital
1982
Abstract Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays strong female bias. By performing genome-wide association study (GWAS) of 3,102 individuals, we identify significant associations with 20p11.22 SNPs for females ( P =6.89 × 10 −9 ) but not males =0.71). This IS also found in independent cohorts from the United States America and Japan (overall =2.15 −10 , OR=1.30 (rs6137473)). Unexpectedly, risk alleles were previously associated protection...
Patients with lumbar spinal stenosis (LSS) tend to bend forward relieve neurological symptoms. They therefore have a positive sagittal vertical axis (SVA). The importance of the SVA value is well known in field adult deformity; however, little about its impact on LSS. authors sought investigate spinopelvic alignment clinical outcome and health-related quality life (HRQOL) after decompression surgery for
Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity, affecting around 2% of adolescents worldwide. Genetic factors play an important role in its etiology. Using a genome-wide association study (GWAS), we recently identified novel AIS susceptibility loci on chromosomes 10q24.31 and 6q24.1. To identify more relating to severity progression, performed GWAS by limiting case subjects those with severe AIS. Through two-stage using total ∼12,000 Japanese subjects, variant,...
Congenital scoliosis (CS) occurs as a result of vertebral malformations and has an incidence 0.5–1/1,000 births. Recently, TBX6 on chromosome 16p11.2 was reported disease gene for CS; about 10% Chinese CS patients were compound heterozygotes rare null mutations common haplotype defined by three SNPs in TBX6. All had hemivertebrae. We recruited 94 Japanese patients, investigated the locus both risk haplotype, examined transcriptional activities mutant vitro, evaluated clinical radiographic...
Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them locus on chromosome 6q24.1 that we by GWAS in Japanese cohort. The represented rs6570507 located within GPR126. To ensure AIS, conducted meta-analysis using eight cohorts from East Asia, Northern Europe USA. analysis included total 6,873 cases 38,916 controls...
Congenital scoliosis (CS), affecting approximately 0.5 to 1 in 1,000 live births, is commonly caused by congenital vertebral malformations (CVMs) arising from aberrant somitogenesis or somite differentiation. While Wnt/ß-catenin signaling has been implicated development, the function of Wnt/planar cell polarity (Wnt/PCP) this process remains unclear. Here, we investigated role
In Brief Study Design. A retrospective case series. Objective. To assess whether a short fusion strategy is applicable when treating adolescent idiopathic scoliosis with Lenke type 5C curve by posterior correction and surgery using pedicle-screw constructs. Summary of Background Data. Previous studies have discussed the selection lower instrumented vertebra to best preserve motion segments obtain coronal balance. However, reports evaluating upper curves are not available. Methods. We...
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity affecting millions of children. Since treatment and prognosis AIS depend on curve progression, identifying factors related to progression important in its management. Although several genetic loci for occurrence are reported, no locus has been identified. To identify genes associated with we conducted genome-wide association study followed by replication using total 2,543 subjects who were evaluated the progression. We...
In Brief Study Design. A genetic association study of single nucleotide polymorphisms (SNPs) previously reported to be associated with curve progression adolescent idiopathic scoliosis (AIS). Objective. To determine whether the 53 SNPs in white patients AIS are replicated Japanese AIS. Summary Background Data. Predicting is important clinical practice The a number genes. Associations have been reported, and used for test AIS; however, there has no replication their association. Methods. We...
The importance of global sagittal alignment is well known. Patients with lumbar spinal stenosis (LSS) generally tend to bend forward relieve their neurological symptoms, i.e., they have a positive vertical axis (SVA). We hypothesized that the SVA associated LSS symptom related and should improve after surgery. However, little known about changes in patients decompression In this study authors aimed evaluate midterm radiographical spinopelvic surgery for determine factors influencing...
Abstract Background Congenital scoliosis (CS) is defined as a lateral curvature of the spine due to vertebral malformations and has an incidence 0.5–1/1,000 births. We previously examined TBX6 in Japanese CS patients revealed that approximately 10% was caused by mutations. However, genetic cause remaining unknown. Methods recruited 78 without mutations major comorbidities, investigated genes reported be associated with congenital whole‐exome sequencing. Results identified compound...
A genetic association study of single nucleotide polymorphisms (SNPs) previously reported to be associated with curve progression adolescent idiopathic scoliosis (AIS).To determine whether the 5 SNPs in Chinese AIS are replicated Japanese patients AIS.AIS is a common spinal deformity and has strong predisposition. Predicting important clinical practice. The number genes. Associations neurotrophin 3, G protein-coupled estrogen receptor, tissue inhibitor metalloproteinase 2 have been Han AIS;...
Spinal extradural arachnoid cyst (SEDAC) is a in the spinal canal that protrudes into epidural space from defect dura mater. Most cases are sporadic; however, three familial SEDAC have been reported, suggesting genetic etiological factors. All associated with lymphedema-distichiasis syndrome (LDS), whose causal gene FOXC2. However, FOXC2 mutation analysis has performed only 1 family, and no on sporadic (non-familial) SEDACs. We recruited 17 subjects consisting of 2 7 examined mutations by...
A retrospective case-control studyShort fusion using pedicle screws (PSs) with an attempt to attain maximum correction of the main thoracic curve was conducted for patients a Lenke type 1 curve, prevent postoperative left shoulder elevation. The outcomes were compared those conventional surgery.Excessive by PSs causes problematic elevation even in curve.Thirty-eight (3 male, 35 female, mean age 16.2 years, follow-up 24 mo) underwent posterior corrective surgery PSs. upper instrumented...