Lori A. Karol

ORCID: 0000-0003-2025-9282
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About
Contact & Profiles
Research Areas
  • Scoliosis diagnosis and treatment
  • Hip disorders and treatments
  • Foot and Ankle Surgery
  • Spinal Fractures and Fixation Techniques
  • Lower Extremity Biomechanics and Pathologies
  • Cerebral Palsy and Movement Disorders
  • Orthopaedic implants and arthroplasty
  • Bone fractures and treatments
  • Pelvic and Acetabular Injuries
  • Diabetic Foot Ulcer Assessment and Management
  • Hip and Femur Fractures
  • Neurogenetic and Muscular Disorders Research
  • Tendon Structure and Treatment
  • Spine and Intervertebral Disc Pathology
  • Connective tissue disorders research
  • Prosthetics and Rehabilitation Robotics
  • Congenital Diaphragmatic Hernia Studies
  • Bone Tumor Diagnosis and Treatments
  • Orthopedic Infections and Treatments
  • Muscle activation and electromyography studies
  • Botulinum Toxin and Related Neurological Disorders
  • Shoulder Injury and Treatment
  • Spinal Dysraphism and Malformations
  • Nerve Injury and Rehabilitation
  • Hereditary Neurological Disorders

The University of Texas Southwestern Medical Center
1999-2024

Texas Scottish Rite Hospital for Children
2013-2024

University of Colorado Denver
2001-2021

Children's Hospital Colorado
2001-2021

Orthopaedic Institute for Children
2021

Duke University
2021

Primary Source
2019

Scottish Rite Hospital
1995-2017

University of Utah
2017

Children's Medical Center
2017

While early spinal fusion may halt progressive deformity in young children with scoliosis, it does not facilitate lung growth and, certain children, can result thoracic insufficiency syndrome. The purpose of this study was to determine pulmonary function at intermediate-term follow-up patients scoliosis who underwent before the age nine years.Patients had spine fusions years a minimum five-year testing. Forced vital capacity, forced expiratory volume one second, and maximum inspiratory...

10.2106/jbjs.g.00184 article EN Journal of Bone and Joint Surgery 2008-06-01

Abstract Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays strong female bias. By performing genome-wide association study (GWAS) of 3,102 individuals, we identify significant associations with 20p11.22 SNPs for females ( P =6.89 × 10 −9 ) but not males =0.71). This IS also found in independent cohorts from the United States America and Japan (overall =2.15 −10 , OR=1.30 (rs6137473)). Unexpectedly, risk alleles were previously associated protection...

10.1038/ncomms7452 article EN cc-by Nature Communications 2015-03-18

Background: Outcomes of orthotic management idiopathic scoliosis depend on patient compliance with brace wear. The purpose this study was to determine if counseling based objective data increases wear and therefore reduces the likelihood surgery. Methods: Two hundred twenty-two patients adolescent were prospectively enrolled in a physician obtained from monitors (sensors embedded brace) improves use decreases curve progression. Patients placed into two groups. In counseled group, aware...

10.2106/jbjs.o.00359 article EN Journal of Bone and Joint Surgery 2016-01-01

Study Design. A review of a clinical series was performed. Objective. To assess the effectiveness orthotic treatment in male patients with idiopathic scoliosis and to compare published data on female patients. Summary Background Data. Although males have been included bracing studies, number has small, there no studies exclusively braced Methods. The medical records 112 age ≥10 years who were prescribed orthoses reviewed confirm etiology, determine brace prescribed, estimate compliance. Cobb...

10.1097/00007632-200109150-00013 article EN Spine 2001-09-01

To determine the influence of Risser sign on need for surgery in children wearing orthoses treatment adolescent idiopathic scoliosis (AIS), data compliance with brace wear were collected and analyzed.One hundred sixty-eight patients prospectively enrolled at time that had been prescribed followed until cessation bracing or surgery. Inclusion criteria a curve magnitude between 25° 45°; stage 0, 1, 2; and, if female, <1 year post menarche prescription. Compliance was measured using thermal...

10.2106/jbjs.15.01313 article EN Journal of Bone and Joint Surgery 2016-08-03

Background: Curve magnitude and skeletal maturity are important factors in determining the efficacy of bracing for treatment adolescent idiopathic scoliosis, but curve morphology may also affect brace success. The purpose this study was to determine influence on response with a thoracolumbosacral orthosis (TLSO). Methods: A retrospective review patients managed an scoliosis who were prospectively enrolled at initiation wear followed through completion or surgery performed. Inclusion criteria...

10.2106/jbjs.16.01050 article EN Journal of Bone and Joint Surgery 2017-06-07

Perioperative halo traction was used in the treatment of severe scoliosis 19 children. Diagnoses included neuromuscular, idiopathic, and congenital scoliosis. Traction transferable between bed a walker or wheelchair. Thirteen patients had prior spinal surgery, most required osteotomy. for 6 to 21 weeks. All underwent fusion surgery after traction, with instrumentation 15 patients. Improvement achieved all The Cobb angle improved 35% from an average 84 degrees before (range 63 -100 ) 55...

10.1097/00004694-200107000-00020 article EN Journal of Pediatric Orthopaedics 2001-07-01

The prevalence of curve progression was evaluated in 210 boys who had idiopathic scoliosis. A minimum age eight years, a deformity at least 10 degrees, and radiographic follow-up one year or the within first were criteria for inclusion study. Of patients, sixty-eight (32 per cent) degrees more. Four five patients an initial 50 more subsequently spinal arthrodesis. risk significantly greater earlier Risser stage (p < 0.002) those younger 0.005). also larger time presentation; sixty-three whom...

10.2106/00004623-199312000-00010 article EN Journal of Bone and Joint Surgery 1993-12-01

Slipped capital femoral epiphyses (SCFE) were created in 10 pair of bovine femurs. Each was pinned with a single screw on one side and two screws contralaterally. The specimens reloaded to failure. Double pin fixation yielded only 33% increase stiffness as compared fixation. Resistance further slip not proportional number. neither double nor approximated that the intact physis. Single slipped is recommended because small gains second do offset risk complications.

10.1097/01241398-199211000-00008 article EN Journal of Pediatric Orthopaedics 1992-11-01

Background: Currently, clubfoot is initially treated with nonoperative methods including the Ponseti cast technique and French functional physical therapy program. Our goal was to evaluate function of children these techniques. Methods: We reviewed cases 182 patients idiopathic (273 feet) who were nonoperatively. Seventy-seven (119 excluded because they had either received a combination treatments or undergone surgery prior testing. Gait analysis performed when approximately two years age....

10.2106/jbjs.g.00201 article EN Journal of Bone and Joint Surgery 2008-07-01

Movement analysis of spinal motion.To compare motion among females with normal spines, those idiopathic scoliosis who had not fusion, and undergone fusion for scoliosis.Previous reports have documented loss following in adolescents adults. To our knowledge, comparison to control groups both without that fusions has been performed date.A total 91 between the ages 15 28 years underwent computerized movement analysis. There were 34 fused patients, 32 unfused 25 healthy controls. The patients...

10.1097/01.brs.0000197168.11815.ec article EN Spine 2006-01-25

The oxygen cost of walking by adults with an amputation has been well described, but few studies have focused on this parameter in children who had amputation. Children a transtibial reported to maintain speed at 15% higher than able-bodied children. purpose study was determine if the level differential impact self-selected and cost, how performance these compares that group children.Seventy-three participated study. Oxygen consumption measured Cosmed K4b2 analysis telemetry unit (Rome,...

10.2106/jbjs.i.01557 article EN Journal of Bone and Joint Surgery 2011-01-05

Background: The purpose of this study was to assess function, at the age 10 years, children initially treated nonoperatively for clubfoot with either Ponseti or French physiotherapy program and compare outcomes in feet that had undergone only nonoperative treatment those required subsequent surgery. Methods: Gait analysis, isokinetic ankle strength, parent-reported outcomes, daily step activity data were collected when patients who been idiopathic reached years. Patients compared...

10.2106/jbjs.18.00317 article EN Journal of Bone and Joint Surgery 2018-12-05

Background: Many studies have demonstrated that orthotic treatment is effective for the prevention of curve progression in patients with adolescent idiopathic scoliosis. However, effect being overweight on outcome has not been reported. The purpose present study was to determine whether scoliosis less successful who are than it those overweight. Methods: A ten-year multicenter retrospective review whom had treated a Boston or custom-molded thoracolumbosacral orthosis performed. inclusion...

10.2106/jbjs.c.01707 article EN Journal of Bone and Joint Surgery 2005-05-01

We conducted gait analysis following initial nonoperative clubfoot treatment to compare lower extremity kinematic (eg, ankle motion) and kinetic power) characteristics between patients treated as infants with Ponseti casting or French physical therapy. This is a followup report of at age 5 years in who had previously been tested 2 years. One hundred-twenty five clubfeet 90 (34 feet only treatment, 40 PT, 51 followed by surgery) were included. The compared those age-matched normal control...

10.1007/s11999-008-0702-9 article EN Clinical Orthopaedics and Related Research 2009-01-21

Recent trends have led to interest in nonoperative treatments for clubfoot (Ponseti casting and French Physiotherapy). Current studies show good sagittal kinematic motion after both the young child, but changes plantar loading these not yet been reported.Pedobarograph data were collected with Emed System on 151 clubfeet, treated either Cast (79 feet) or physiotherapy (PT, 72 feet), at age of 2 years. Medial lateral differences pressures, contact area, time, assessed hindfoot, midfoot,...

10.1097/bpo.0b013e3181c6c4de article EN Journal of Pediatric Orthopaedics 2010-01-01

Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them locus on chromosome 6q24.1 that we by GWAS in Japanese cohort. The represented rs6570507 located within GPR126. To ensure AIS, conducted meta-analysis using eight cohorts from East Asia, Northern Europe USA. analysis included total 6,873 cases 38,916 controls...

10.1038/s41598-018-29011-7 article EN cc-by Scientific Reports 2018-07-26

Perioperative halo traction was used in the treatment of severe scoliosis 19 children. Diagnoses included neuromuscular, idiopathic, and congenital scoliosis. Traction transferable between bed a walker or wheelchair. Thirteen patients had prior spinal surgery, most required osteotomy. for 6 to 21 weeks. All underwent fusion surgery after traction, with instrumentation 15 patients. Improvement achieved all The Cobb angle improved 35% from an average 84° before (range 63°–100°) 55° preceding...

10.1097/01241398-200107000-00020 article EN Journal of Pediatric Orthopaedics 2001-07-01

Thirty-two patients who had medial open reduction of 40 hips were reviewed at an average 10.3 years follow-up (range 2.5-18.6 y). Center-edge angles and acetabular indices measured on preoperative, postoperative, final radiographs. The presence AVN was noted. radiograph assigned a Severin grade. One hip re-dislocated. Eight (20%) have required subsequent pelvic osteotomies. developed in 11 (27.5%). Of the 11, five classified as type I, defined temporary irregular ossification femoral head....

10.1097/00004694-200301000-00001 article EN Journal of Pediatric Orthopaedics 2003-01-01
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