Normal hearing depends on the ability to distinguish self-generated sounds from other sounds, and this is thought involve neural circuits that convey copies of motor command signals various levels auditory system. Although such interactions at cortical level are believed facilitate comprehension during movements drive hallucinations in pathological states, synaptic organization function circuitry linking cortices remain unclear. Here we describe experiments mouse characterize well suited...

In the auditory system, stimulus-response properties of single neurons are often described in terms spectrotemporal receptive field (STRF), a linear kernel relating spectrogram sound stimulus to instantaneous firing rate neuron. Several algorithms have been used estimate STRFs from responses natural stimuli; these differ their functional models, cost functions, and regularization methods. Here, we characterize function using generalized model (GLM). this model, each cell's input is by: 1)...

Neurons in the mouse auditory cortex are strongly influenced by behavior, including both suppression and enhancement of sound-evoked responses during movement. The comprises multiple fields with different roles sound processing distinct connectivity to movement-related centers brain. Here, we asked whether modulation male mice might differ across cortical fields, thereby contributing heterogeneity at single-cell level. We used wide-field calcium imaging identify cellular-resolution...

Recent electrophysiological studies on the primate amygdala have advanced our understanding of how individual neurons encode information relevant to emotional processes, but it remains unclear these are functionally and anatomically organized. To address this, we analyzed cross-correlograms spike trains recorded during a task in which monkeys learned associate novel images with rewarding aversive outcomes. Using this task, recently described two populations neurons: one that responds more...

Comparing expectation with experience is an important neural computation performed throughout the brain and a hallmark of predictive processing. Experiments that alter sensory outcome animal's behavior reveal enhanced responses to unexpected self-generated stimuli, indicating populations neurons in cortex may reflect prediction errors (PEs), mismatches between experience. However, stimuli could also arise through nonpredictive mechanisms, such as movement-based facilitation neuron's inherent...

Natural behavior requires close but flexible coordination between attention, defined as selection for perception, and action. In recent years a distributed network including the lateral intraparietal area (LIP) has been implicated in visuospatial attention rapid eye movements (saccades), relation attentional motor functions of this remains unclear. Here we tested LIP neurons task that involved not an ocular manual operant response. Monkeys viewed display containing one cue several...

It has long been known that the brain is limited in amount of sensory information it can process at any given time. A well-known form capacity limitation vision set-size effect, whereby time needed to find a target increases presence distractors. The effect implies inputs from multiple objects interfere with each other, but loci and mechanisms this interference are unknown. Here we show neural correlate competitive visuo-visual interactions lateral intraparietal area, an area related spatial...

The majority of sensory physiology experiments have used anesthesia to facilitate the recording neural activity. Current techniques allow researchers study function in context varying behavioral states. To reconcile results across multiple and anesthetic states, it is important consider how what extent plays a role shaping response properties. has been subject much debate, but which coding properties are altered by yet be fully defined. In this we asked urethane, an commonly for avian...

Many social animals including songbirds use communication vocalizations for individual recognition. The perception of depends on the encoding complex sounds by neurons in ascending auditory system, each which is tuned to a particular subset acoustic features. Here, we examined how well responses single could be used discriminate among bird songs and compared discriminability spectrotemporal tuning. We then biologically realistic models pooled neural test whether groups discriminated better...

ABSTRACT Neurons in the mouse auditory cortex are strongly influenced by behavior, including both suppression and enhancement of sound-evoked responses during movement. The comprises multiple fields with different roles sound processing distinct connectivity to movement-related centers brain. Here, we asked whether modulation might differ across cortical fields, thereby contributing heterogeneity at single-cell level. We used wide-field calcium imaging identify followed cellular-resolution...

The receptive fields of many sensory neurons are sensitive to statistical differences among classes complex stimuli. For example, excitatory spectral bandwidths midbrain auditory and the spatial extent cortical visual differ during processing natural stimuli compared artificial Experimentally characterizing neuronal nonlinearities that contribute stimulus-dependent is important for understanding how respond different stimulus in multiple modalities. Here we show zebra finch, have...

Abstract Many of the sensations experienced by an organism are caused their own actions, and accurately anticipating both sensory features timing self-generated stimuli is crucial to a variety behaviors. In auditory cortex, neural responses sounds exhibit frequency-specific suppression, suggesting that movement-based predictions may be implemented early in processing. Yet it remains unknown whether this modulation results from behaviorally specific temporally precise prediction, nor known...

Comparing expectation with experience is an important neural computation performed throughout the brain and a hallmark of predictive processing. Experiments that alter sensory outcome animal's behavior reveal enhanced responses to unexpected self-generated stimuli, indicating populations neurons in cortex may reflect prediction errors - mismatches between experience. However, stimuli could also arise through non-predictive mechanisms, such as movement-based facilitation neuron's inherent...

Birdsong is comprised of rich spectral and temporal organization, which might be used for vocal perception. To quantify how this structure could used, we have reconstructed birdsong spectrograms by combining the spike trains zebra finch auditory midbrain neurons with information about correlations present in song. We calculated maximum a posteriori estimates song using generalized linear model neuronal responses series prior distributions, each carrying different amounts statistical found...

The cortex integrates sound- and movement-related signals to predict the acoustic consequences of behavior detect violations from expectations. Although expectation- prediction-related activity has been observed in auditory humans, monkeys, mice during vocal non-vocal behaviors, specific cortical circuitry required for forming memories, recalling expectations, making predictions remains unknown. By combining closed-loop behavior, electrophysiological recordings, longitudinal pharmacology,...

During behavior, the motor cortex sends copies of motor-related signals to sensory cortices. Here, we combine closed-loop behavior with large-scale physiology, projection-pattern-specific recordings, and circuit perturbations show that neurons in mouse secondary (M2) encode sensation are influenced by expectation. When a movement unexpectedly produces sound, M2 becomes dominated sound-evoked activity. Sound responses inherited partially from auditory routed back cortex, providing path for...