A5079022897- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Cooperative Communication and Network Coding
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Mobile Ad Hoc Networks
- Plant nutrient uptake and metabolism
- Neurobiology and Insect Physiology Research
- Receptor Mechanisms and Signaling
- Analytical Chemistry and Sensors
- Neurogenesis and neuroplasticity mechanisms
- Advanced MIMO Systems Optimization
- Advanced Chemical Sensor Technologies
- Food Quality and Safety Studies
- Chromosomal and Genetic Variations
- Advanced Wireless Communication Technologies
- Stress Responses and Cortisol
- Full-Duplex Wireless Communications
- Neurotransmitter Receptor Influence on Behavior
- Plant Molecular Biology Research
- Biosensors and Analytical Detection
- Electrochemical Analysis and Applications
- Autism Spectrum Disorder Research
- Reproductive biology and impacts on aquatic species
- Wireless Communication Security Techniques
Jeonbuk National University
2006-2025
Janelia Research Campus
2021-2024
Howard Hughes Medical Institute
2021-2024
Duke University
2014-2023
Korea University
2009-2022
Trinity College
2020
Kangwon National University
1998-2019
Korea Food Research Institute
1998-2018
The University of Texas at El Paso
2017
Institute of Neurobiology
2015
Abstract Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and circuit mechanisms underlying ASDs remain elusive. Here, we describe a complete knockout mouse model of autism-associated Shank3 gene, with deletion exons 4–22 (Δe4–22). Both mGluR5-Homer scaffolds mGluR5-mediated signalling are selectively altered striatal neurons. These changes associated perturbed function at synapses,...
Significance Excitable axonal membrane microdomains are unique features of vertebrate nervous systems that required for normal neuronal signaling and involved in human neurological disorders. Ankyrin-G is a critical adaptor protein acquired giant exon early evolution, resulting new system-specific polypeptide master organizer excitable membranes. Giant ankyrin-G–deficient mice live to weaning provide rationale survival humans with severe cognitive dysfunction bearing truncating mutation the...
Astrocytes control excitatory synaptogenesis by secreting thrombospondins (TSPs), which function via their neuronal receptor, the calcium channel subunit α2δ-1. α2δ-1 is a drug target for epilepsy and neuropathic pain; thus TSP–α2δ-1 interaction implicated in both synaptic development disease pathogenesis. However, mechanism this promotes requirement connectivity of developing mammalian brain are unknown. In study, we show that global or cell-specific loss yields profound deficits synapse...
We previously reported a new line of Shank3 mutant mice which led to complete loss by deleting exons 4-22 (Δe4-22) globally. Δe4-22 display robust ASD-like behaviors including impaired social interaction and communication, increased stereotypical behavior excessive grooming, profound deficit in instrumental learning. However, the anatomical neural circuitry underlying these are unknown. generated with selectively deleted forebrain, striatum, striatal D1 D2 cells. These were used interrogate...
Giant ankyrin-B (ankB) is a neurospecific alternatively spliced variant of ANK2, high-confidence autism spectrum disorder (ASD) gene. We report that mouse model for human ASD mutation giant ankB exhibits increased axonal branching in cultured neurons with ectopic CNS axon connectivity, as well transient increase excitatory synapses during postnatal development. elucidate mechanism normally limiting branching, whereby localizes to periodic plasma membrane domains through L1 cell-adhesion...
Abstract Although the basal ganglia have long been implicated in initiation of actions, their contribution to movement remains a matter dispute. Using wireless multi‐electrode recording and motion tracking, we examined relationship between single‐unit activity sensorimotor striatum kinematics. We recorded from medium spiny projection neurons fast‐spiking interneurons while monitoring movements mice using tracking. In E xperiment 1, trained generate reliably by water‐depriving them giving...
Habit formation is a behavioral adaptation that automates routine actions. Habitual behavior correlates with broad reconfigurations of dorsolateral striatal (DLS) circuit properties increase gain and shift pathway timing. The mechanism(s) for these adaptations are unknown could be responsible habitual behavior. Here we find single class interneuron, fast-spiking interneurons (FSIs), modulates all habit-predictive properties. Consistent role in habits, FSIs more excitable mice compared to...
Selective activation of Pf-STN pathway initiates actions in normal mice and restores movement a mouse model PD.
Dysfunctional sociability is a core symptom in autism spectrum disorder (ASD) that may arise from neural-network dysconnectivity between multiple brain regions. However, pathogenic mechanisms underlying social dysfunction are largely unknown. Here, we demonstrate circuit-selective mutation (ctMUT) of ASD-risk Shank3 gene within unidirectional projection the prefrontal cortex to basolateral amygdala alters spine morphology and excitatory-inhibitory balance circuit. ctMUT mice show reduced as...
Huntington's disease (HD) is caused by an autosomal dominant polyglutamine expansion mutation of Huntingtin (HTT). HD patients suffer from progressive motor, cognitive, and psychiatric impairments, along with significant degeneration the striatal projection neurons (SPNs) striatum. widely accepted to be a toxic gain-of-function mutant HTT. However, whether loss HTT function, because dominant-negative effects protein, plays role in required for SPN health function are not known. Here, we...
Abstract Most adaptive behaviors require precise tracking of targets in space. In pursuit behavior with a moving target, mice use distance to target guide their own movement continuously. Here, we show that the sensorimotor striatum, parvalbumin-positive fast-spiking interneurons (FSIs) can represent between self and during behavior, while striatal projection neurons (SPNs), which receive FSI projections, self-velocity. FSIs are shown regulate velocity-related SPN activity pursuit, so...
Psychiatric disorders are highly heritable pathologies of altered neural circuit functioning. How genetic mutations lead to specific abnormalities underlying behavioral disruptions, however, remains unclear. Using circuit-selective transgenic tools and a mouse model maladaptive social behavior (ArpC3 mutant), we identify mechanism driving dysfunctional behavior. We demonstrate that knockout (ctKO) the ArpC3 gene within prefrontal cortical neurons project basolateral amygdala elevates...
<br>Dental health has historically received little attention in veterinary medicine, but is becoming more common. This study aimed to report the prevalence of dental extractions dogs Seoul, Republic Korea, describe current status and determine any preventive methods. In total, 166 participated study, presented hospital with an oral disorder or for a routine check-up were included study. Teeth extracted from 130 (78.32%). A single tooth was 18 (13.85%), whereas multiple teeth (2–29 teeth) 112...
The ability to regulate emotional responses in various circumstances would provide adaptive advantages for an individual. Using a context-dependent fear discrimination (CDFD) task which the tone conditioned stimulus (CS) is paired with footshock unconditioned (US) one context but presented alone another context, we investigated role of prelimbic (PL) cortex contextual modulation response. After 3 days CDFD training, rats froze more CS fearful than safe context. Following bilateral lesions...
Cell therapy demonstrates great potential for the treatment of neurological disorders. Human umbilical tissue-derived cells (hUTCs) were previously shown to have protective and regenerative effects in animal models stroke retinal degeneration, but underlying therapeutic mechanisms are unknown. Because synaptic dysfunction, synapse loss, degeneration neuronal processes, death hallmarks diseases degenerations, we tested whether hUTCs contribute tissue repair regeneration by stimulating...