A5100759354- Functional Brain Connectivity Studies
- Pharmacogenetics and Drug Metabolism
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Sphingolipid Metabolism and Signaling
- Heart Rate Variability and Autonomic Control
- Carbohydrate Chemistry and Synthesis
- Synthetic Organic Chemistry Methods
- Eicosanoids and Hypertension Pharmacology
- Genomics and Phylogenetic Studies
- EEG and Brain-Computer Interfaces
- Fungal Biology and Applications
- Inflammatory mediators and NSAID effects
- Mental Health Research Topics
- Healthcare and Venom Research
- Face Recognition and Perception
- Memory and Neural Mechanisms
- Drug Transport and Resistance Mechanisms
- Traditional Chinese Medicine Studies
- Microstructure and Mechanical Properties of Steels
- Cultural and Historical Studies
- Consumer Perception and Purchasing Behavior
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- NF-κB Signaling Pathways
National Institute of Agricultural Science and Technology
2016-2024
Virginia Tech
2019-2024
Kyungpook National University
2015-2024
Chung-Ang University
2024
Korea University
2009-2023
Gachon University Gil Medical Center
2021-2022
National Medical Center
2018-2022
University of Southern California
2012-2021
Gangnam Severance Hospital
2020-2021
Yonsei University
2004-2021
α-GalCer is the first defined and most potent agonistic antigen of T cell receptor natural killer cells. We have prepared a series 1,2,3-triazole-containing analogues in which lipid chain lengths been incrementally varied. found that this isosteric replacement α-GalCer's amide moiety with triazole increases IL-4 versus IFN-γ bias released cytokines. The stimulatory effect was influenced by length attached chain. In particular, long-chained comparable on cytokine production as exhibit...
Recent models posit that bursts of locus ceruleus (LC) activity amplify neural gain such limited attention and encoding resources focus even more on prioritized mental representations under arousal. Here, we tested this hypothesis in human males females using fMRI, neuromelanin MRI, pupil dilation, a biomarker arousal LC activity. During scanning, participants performed monetary incentive task which threat punishment motivated them to prioritize scene images over superimposed objects. Threat...
Amorphous KNbO3 (KN) films were grown on a TiN/SiO2/Si substrate to synthesize KN memristor as potential artificial synapse. The Pt/KN/TiN exhibited typical and reliable bipolar switching behavior with multiple resistance levels. It also showed the transmission properties of biological synapse, good conductance modulation linearity. Moreover, can emulate various synaptic plasticity characteristics including short-term plasticity, long-term spike-rate dependent paired-pulse facilitation,...
Abstract Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains mystery. To identify genes responsible for plant anthraquinone biosynthesis, we reveal genome sequence S. at chromosome level with 526 Mb (96%) assembled into 13 chromosomes. Comparison among related species shows that chalcone synthase-like (CHS-L) gene family has lineage-specifically and rapidly expanded . Combining...
Researchers generally agree that when upregulating and downregulating emotion, control regions in the prefrontal cortex turn up or down activity affect-generating brain areas. However, “affective dial hypothesis” turning emotions produces opposite effects same is untested. We tested this hypothesis by examining overlap between activated during upregulation those deactivated downregulation 54 male 51 female humans. found both recruit regulatory regions, such as inferior frontal gyrus dorsal...
Two new fusicoccane diterpenes, named periconicins A (1) and B (2), with antibacterial activities have been isolated by bioassay-guided fractionation from an endophytic fungus Periconia sp., collected small branches of Taxus cuspidata. The structures the compounds were determined combined spectroscopic methods.
The arousal-biased competition model predicts that arousal increases the gain on neural between stimuli representations. Thus, simultaneously enhances processing of salient and impairs relatively less-salient stimuli. We tested this with a simple dot-probe task. On each trial, participants were exposed to one face image as cue stimulus place non-salient stimulus. A border around location further increased its bottom-up saliency. Before these visual shown, two tones played: predicted shock...
A bio-realistic artificial synapse integrated with a nanogenerator (NG), which can be used in neuromorphic systems, is demonstrated for self-powered biomedical devices this study. Biocompatible amorphous (Na0.5K0.5)NbO3 (NKN) films are grown on TiN/polyimide substrates to synthesize NKN memristors use as synapses. Various synaptic functions realized memristors, driven by pulse generator and an NG. The plasticity of the memristor results from oxygen vacancy movements changes shape filaments....
Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits dehydrogenase-mediated conversion cytosolic to mitochondrial acetyl-CoA, as a metabolic checkpoint M1 macrophages. Polarization was not prevented by PDK2 or PDK4 deletion but fully combined PDK4; this lack correlated with improved respiration rewiring breaks are characterized increased...
Steel is the global backbone material of industrialized societies, with more than 1.8 billion tons produced per year. However, steel-containing structures decay due to corrosion, destroying annually 3.4% (2.5 trillion US$) gross domestic product. Besides this huge loss in value, a solution corrosion problem at minimum environmental impact would also leverage enhanced product longevity, providing an immense contribution sustainability. Here, we report leap forward toward aim through...
Dysfunctional sociability is a core symptom in autism spectrum disorder (ASD) that may arise from neural-network dysconnectivity between multiple brain regions. However, pathogenic mechanisms underlying social dysfunction are largely unknown. Here, we demonstrate circuit-selective mutation (ctMUT) of ASD-risk Shank3 gene within unidirectional projection the prefrontal cortex to basolateral amygdala alters spine morphology and excitatory-inhibitory balance circuit. ctMUT mice show reduced as...
The COVID-19 pandemic has made an unprecedented shift in children's daily lives. Children are increasingly spending time with screens to learn and connect others. As the online environment rapidly substitutes in-person experience, understanding neuropsychological trajectories associated screen experiences is important. Previous findings suggest that excessive use can lead children prefer more immediate rewards over delayed outcomes. We hypothesized increased delays a child's development of...
People from Asian cultures are more influenced by context in their visual processing than people Western cultures. In this study, we examined how these cultural differences affect interpret facial emotions. We found that younger Koreans were Americans emotional background pictures when rating the emotion of a central face, especially those with low self-rated stress. contrast, among older adults, neither nor showed significant influences face ratings. These findings suggest reliance on to...
Keeping limber: A monolithic and flexible polyimide film microreactor is introduced for organic reactions syntheses. Unlike glass microreactors, it easy to fabricate, yet inert solvents acids under harsh conditions, unlike other polymer microreactors. Detailed facts of importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: The publisher responsible...
Arousal-biased competition theory predicts that arousal biases in favor of perceptually salient stimuli and against non-salient (Mather Sutherland, 2011). The current study tested this hypothesis by having observers complete many trials a visual search task which the target either always was (a 55° tilted line among 80° distractors) or 50° distractors). Each participant completed one session an emotional condition, were preceded negative arousing images, non-emotional images replaced with...
Recent evidence indicates that emotion enhances contrast thresholds in subsequent visual perception (Phelps, Ling, & Carrasco, 2006) and perceptual sensitivity for low-spatial frequency but not high-spatial targets (Bocanegra Zeelenberg, 2009b).However, these studies just report responses to various frequencies at a fixed level or contrasts frequency.In the current study, we measured full function as of emotional arousal order investigate potential interactions between spatial contrast.We...