A5047672848- Acute Kidney Injury Research
- Parathyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Heterotopic Ossification and Related Conditions
- Tryptophan and brain disorders
- Advanced Glycation End Products research
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Redox biology and oxidative stress
- Genomics, phytochemicals, and oxidative stress
- Macrophage Migration Inhibitory Factor
- Bioactive Compounds and Antitumor Agents
- Diet, Metabolism, and Disease
- Mitochondrial Function and Pathology
- Electrolyte and hormonal disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetic Syndromes and Imprinting
- Natural Antidiabetic Agents Studies
- Pharmacological Effects and Toxicity Studies
- Cardiac Ischemia and Reperfusion
- Chronic Kidney Disease and Diabetes
- Endoplasmic Reticulum Stress and Disease
- Chemotherapy-induced organ toxicity mitigation
- Coronary Interventions and Diagnostics
- Connective Tissue Growth Factor Research
Kyungpook National University
2011-2024
Kyungpook National University Hospital
2022-2023
Institute of Aging
2023
Keimyung University
2009-2010
Chonnam National University
2010
Gunma University
2010
University of Ulsan
2009-2010
Ulsan College
2009-2010
Seoul National University
2010
Inha University
2010
TGF-β plays a key role in the development of renal fibrosis. Suppressing signaling pathway is possible therapeutic approach for preventing this disease, and reports have suggested that Nrf2 protects against fibrosis by inhibiting signaling. This study examines whether dimethylfumarate (DMF), which stimulates Nrf2, prevents via Nrf2-mediated suppression Results showed DMF increased nuclear levels both adenovirus-mediated overexpression (Ad-Nrf2) decreased PAI-1, alpha-smooth muscle actin...
Vascular calcification, a pathologic response to defective calcium and phosphate homeostasis, is strongly associated with cardiovascular mortality morbidity. In this study, we have observed that pyruvate dehydrogenase kinase 4 (PDK4) upregulated complex phosphorylation increased in calcifying vascular smooth muscle cells (VSMCs) calcified vessels of patients atherosclerosis, suggesting PDK4 plays an important role calcification. Both genetic pharmacological inhibition ameliorated the...
Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits dehydrogenase-mediated conversion cytosolic to mitochondrial acetyl-CoA, as a metabolic checkpoint M1 macrophages. Polarization was not prevented by PDK2 or PDK4 deletion but fully combined PDK4; this lack correlated with improved respiration rewiring breaks are characterized increased...
Dynamic regulation of mitochondrial morphology provides cells with the flexibility required to adapt and respond electron transport chain (ETC) toxins DNA-linked disease mutations, yet mechanisms underpinning dynamics machinery by these stimuli is poorly understood. Here, we show that pyruvate dehydrogenase kinase 4 (PDK4) genetically for undergo rapid fragmentation when challenged ETC toxins. Moreover, PDK4 overexpression was sufficient promote fission even in absence stress. Importantly,...
Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are important pathogenic mechanisms in atherosclerosis restenosis after injury. In this study, we investigated the effects beta-lapachone (betaL) (3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione), which is a potent antitumor agent that stimulates NAD(P)H:quinone oxidoreductase (NQO)1 activity, on neointimal formation animals given injury VSMCs cultured vitro. betaL significantly reduced induced by balloon...
Excessive proliferation of vascular smooth muscle cells (VSMCs) and incomplete re-endothelialization is a major clinical problem limiting the long-term efficacy percutaneous coronary angioplasty. We tested if dimethylfumarate (DMF), an anti-psoriasis drug, could inhibit abnormal remodeling via NF−E2-related factor 2 (Nrf2)-NAD(P)H quinone oxidoreductase 1 (NQO1) activity. DMF significantly attenuated neointimal hyperplasia induced by balloon injury in rat carotid arteries suppression G1 to S...
The excessive accumulation of adipocytes contributes to the development obesity and obesity-related diseases. interactions several transcription factors, such as C/EBPβ, PPARγ, C/EBPα, Nrf2, STAT3, are required for adipogenic differentiation. Dimethylfumarate (DMF), an immune modulator antioxidant, may function inhibitor STAT3 activator Nrf2. This study examined whether DMF inhibits differentiation 3T3-L1 preadipocytes by inhibiting or activating suppressed preadipocyte mature in a...
Background: Reactive oxygen species (ROS) and inflammation are reported to have a fundamental role in the pathogenesis of ischemia-reperfusion (IR) injury, leading cause acute kidney injury. The present study investigated pyruvate dehydrogenase kinase 4 (PDK4) ROS production following IR injury.Methods: We used streptozotocin-induced diabetic C57BL6/J mouse model, which was subjected by clamping both renal pedicles. Cellular apoptosis inflammatory markers were evaluated NRK-52E cells primary...
To explore whether α-lipoic acid (ALA), a naturally occurring antioxidant, inhibits neointimal hyperplasia by inducing apoptosis of vascular smooth muscle cells and to examine its potential effects on reendothelialization platelet aggregation.Restenosis late stent thrombosis, caused delayed reendothelialization, are significant clinical problems balloon angioplasty drug-eluting stents. ALA treatment strongly induced enhanced the expression cytoplasmic localization Nur77, which triggers...
Emerging evidence suggest that transcription factors play multiple roles in the development of pancreatitis, a necroinflammatory condition lacking specific therapy. Estrogen-related receptor γ (ERRγ), pleiotropic factor, has been reported to vital role pancreatic acinar cell (PAC) homeostasis. However, ERRγ PAC dysfunction remains hitherto unknown. Here, we demonstrated both mice models and human cohorts pancreatitis is associated with an increase gene expression via activation STAT3....
Scoparone, which is a major constituent of Artemisia capillaries, has been identified as an anticoagulant, hypolipidemic, vasorelaxant, anti-oxidant and anti-inflammatory drug, it used for the traditional treatment neonatal jaundice. Therefore, we hypothesized that scoparone could suppress proliferation VSMCs by interfering with STAT3 signaling. We found these cells was significantly attenuated in dose-dependent manner. Scoparone markedly reduced serum-stimulated accumulation S phase...
Dyslipidemia-induced atherosclerosis, which has a risk of high morbidity and mortality, can be alleviated by metabolic activation associated with mitochondrial function. The effect dichloroacetate (DCA), general pyruvate dehydrogenase kinase (PDK) inhibitor, on in vivo energy expenditure ApoE-/- mice fed western diet (WD) not yet been investigated. WD-fed developed atherosclerotic plaques hyperlipidemia along obesity, were significantly ameliorated DCA administration. Increased oxygen...
A high concentration of glucose has been implicated as a causal factor in initiation and progression diabetic complications there is evidence to suggest that hyperglycemia increases the production free radicals oxidative stress. Therefore, compounds scavenge reactive oxygen species (ROS) may confer regulatory effects on glucose-induced apoptosis. Ursolic acid (UA), pentacyclic triterpene, reported have an antioxidant activity. We investigated effect UA apoptosis U937 cells. Upon exposure 35...
Cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) is susceptible to inactivation by numerous thiol-modifying reagents. This study now reports that Cys269 of IDPc a target for S-glutathionylation and this modification reversed dithiothreitol as well enzymatically cytosolic glutaredoxin in the presence GSH. Glutathionylated was significantly less than native protein peptide fragmentation reactive oxygen species proteolytic digestion. Glutathionylation may play protective role...
CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode action remains to be elucidated. KK-Ay mice, type 2 diabetes mellitus (T2DM) model, were administered CycloZ either as preventive intervention, or therapy. Glycemic control was evaluated using the oral glucose tolerance test (OGTT), glycosylated hemoglobin (HbA1c) levels. Liver visceral adipose tissues (VATs) used for histological evaluation, gene expression analysis, protein analysis....