A5100375427- Insect symbiosis and bacterial influences
- Pancreatic function and diabetes
- Invertebrate Immune Response Mechanisms
- Insect-Plant Interactions and Control
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Insect Resistance and Genetics
- Hippo pathway signaling and YAP/TAZ
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Pancreatitis Pathology and Treatment
- Mosquito-borne diseases and control
- Insect and Arachnid Ecology and Behavior
- Autophagy in Disease and Therapy
- CRISPR and Genetic Engineering
- Microbial metabolism and enzyme function
- Cellular Mechanics and Interactions
- Genomics and Phylogenetic Studies
- Amino Acid Enzymes and Metabolism
- Lung Cancer Treatments and Mutations
- Cellular transport and secretion
- Pancreatic and Hepatic Oncology Research
- Enzyme Catalysis and Immobilization
Nanjing Medical University
2025
Wenzhou Medical University
2024-2025
First Affiliated Hospital of Wenzhou Medical University
2024-2025
Tongji University
2023-2025
Yunnan Open University
2025
China Pharmaceutical University
2024-2025
Harbin Medical University
2023-2025
Third Affiliated Hospital of Harbin Medical University
2023-2025
Peking University
2023-2025
Shanghai Pulmonary Hospital
2025
The non-receptor cytoplasmic tyrosine kinase, Focal Adhesion Kinase (FAK) is known to play a key role in variety of normal and cancer cellular functions such as survival, proliferation, migration invasion. It highly active overexpressed various cancers including Pancreatic Ductal Adenocarcinoma (PDAC) Malignant Pleural Mesothelioma (MPM). Here, initially, we demonstrate that FAK both PDAC MPM cell lines. Then analyze effects two small molecule inhibitors PF-573228, PF-431396, which are dual...
In this work, the effect of dual-frequency ultrasound-assisted ionic liquids (ILs) pretreatment on functional properties soy protein isolate (SPI) hydrolysates was investigated. The degree hydrolysis (DH) SPI pretreated by ultrasound and [BMIM][PF6] increased 12.53% as compared to control (P < 0.05). More peptides with low molecular weight were obtained, providing support for changes in DH. trichloroacetic acid-nitrogen soluble index presented an increase, suggesting a better hydrolysate...
Pancreatic cancer is one of the most common malignant diseases in world. Gemcitabine chemotherapy remains important clinical treatment. However, research found that pancreatic cells have chemoresistance to gemcitabine and effect not satisfactory. Therefore, it urgent find an effective early diagnosis treatment strategy. Circular RNA popular prognostic biomarkers GEM-resistant PC. The present study was designed evaluate role circHIPK3 expression PC tissues its on proliferation, migration,...
Gemcitabine (GEM) is one of the most widely chemotherapy drugs in PC. However, resistance always occurs after a period treatment indicating poor prognosis. lncRNA may play an essential role PC and serve as prognosis biomarkers with GEM-resistance. In our study, we aim to investigate HCP5 PC.QRT-PCR detected expression HCP5. The effects knockdown on proliferation, migration, invasion, cell apoptosis autophagy were investigated GEM-resistance cells. Bioinformatic analysis, luciferase reporter...
Acute pancreatitis (AP) is a disease characterized by local and systemic inflammation with an increasing incidence worldwide. Receptor-interacting serine/threonine protein kinase 3 (RIPK3), mixed-lineage domain-like (MLKL), innate immune cell macrophages have been reported to be involved in the pathogenesis of AP. However, mechanisms which RIPK3 MLKL regulate pancreatic injury, as well interactions between injured acinar cells infiltrating AP, remain poorly defined. In present study,...
Abstract Parasitoid wasps represent a large proportion of hymenopteran species. They have complex evolutionary histories and are important biocontrol agents. To advance parasitoid research, combination Illumina short‐read, PacBio long‐read Hi‐C scaffolding technologies was used to develop high‐quality chromosome‐level genome assembly for Pteromalus puparum , which is an pupal endoparasitoid caterpillar pests. The has aided in studies venom detoxification genes. assembled size 338 Mb with...
Acute pancreatitis (AP), especially severe acute (SAP), is extremely dangerous ill with a high mortality rate. Pyroptotic cells releases the cellular contents and inflammatory factors, aggravating response. Pyroptosis may be main way of acinar cell death during AP. Circular RNA circHIPK3 expressed in pancreatic tissue associated In this study, we focused on role underlying mechanism We found that expression was significantly elevated serum patients AP caerulein-stimulated AR42J cells,...
With the difficulties in choosing colistin sulfate and polymyxin B (PBS) for carbapenem-resistant gram-negative bacteria (CR-GNB), we compared efficacy safety of these two old polymyxins treatment critically ill patients infected with CR-GNB infection.One hundred four ICU were retrospectively grouped by PBS (68 patients) or (36 patients). Clinical including symptoms, inflammatory parameters, defervescence, prognosis microbial analyzed. Hepatotoxicity, nephrotoxicity, hematotoxicity evaluated...
Background Postoperative pneumonia (POP) is one of the primary complications after aneurysmal subarachnoid hemorrhage (aSAH) and associated with postoperative mortality, extended hospital stay, increased medical fee. Early identification more aggressive treatment can improve patient outcomes. We aimed to develop a model predict POP in aSAH patients using machine learning (ML) methods. Methods This internal cohort study included 706 undergoing intracranial aneurysm embolization or clipping....
Abstract Pontederia cordata L. is an aquatic ornamental plant native to the Americas, but has been widely distributed in South Asia, Australia, and Europe. The genetic mechanisms behind its rapid adaptation spread have not yet well understood. To understand for adaptation, this study assembled first chromosome-level genome of P. cordata. assembly, which spans 527.5 Mb, anchored on eight pseudochromosomes with a scaffold N50 48 Mb encompasses 29,389 protein-coding genes. Further analyses...
Blood urea/creatinine (U/Cr) ratio is considered to be an ideal biomarker of dehydration. We investigated the association between U/Cr trajectory and delayed cerebral ischemia (DCI) as well functional outcome in aneurysmal subarachnoid hemorrhage (aSAH). Additionally, we explored role DCI a mediator its interaction with Consecutive aSAH patients were reviewed. A latent class growth mixture model (LCGMM) was applied classify dehydration over 7 days. Multivariate logistic regression conducted...
A deeper understanding of pathophysiology, from the initiation tumors epithelial cells to outcomes associated with it, is imperative test potential interventions for these diseases. However, few models can accomplish this because complexity origin and their transformation. We established an cell original tumor mouse model by conditional KrasG12D activation suppressor gene p53 deletion specifically in whole body using Cytokeratin 19 (CK19) promoter via Cre-ERT mediation. Multiple derived...