A5100418599- Cancer Research and Treatments
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Clostridium difficile and Clostridium perfringens research
- Tissue Engineering and Regenerative Medicine
- Nerve injury and regeneration
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Viral Infections and Vectors
- RNA Interference and Gene Delivery
- Reconstructive Surgery and Microvascular Techniques
- CAR-T cell therapy research
- Cellular Mechanics and Interactions
- Organ Transplantation Techniques and Outcomes
- Cancer Cells and Metastasis
- Protein Hydrolysis and Bioactive Peptides
- Colorectal Cancer Treatments and Studies
- Glycosylation and Glycoproteins Research
- Transgenic Plants and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- CRISPR and Genetic Engineering
- Urological Disorders and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
Yulin University
2025
Nanyang Institute of Technology
2025
Suzhou Municipal Hospital
2024-2025
Nanjing Medical University
2016-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2019-2025
Liaocheng University
2025
Neurological Surgery
2023-2024
Indiana University – Purdue University Indianapolis
2023-2024
Indiana University School of Medicine
2023-2024
See also the Commentary by Mao and Liu
Background and Aims The gap between patients on transplant waiting lists available donor organs is steadily increasing. Human organoids derived from leucine‐rich repeat‐containing G protein‐coupled receptor 5 (LGR5)–positive adult stem cells represent an exciting new cell source for liver regeneration; however, culturing large numbers of with current protocols tedious the level hepatic differentiation limited. Approach Results Here, we established a method expansion quantities human in...
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by invasive behavior and compromised immune response, presenting treatment challenges. Surgical debulking of GBM fails to address its infiltrative nature, leaving neoplastic satellites in an environment impaired surveillance, ultimately paving the way for recurrence. Tracking eradicating residual cells boosting antitumor immunity critical preventing postoperative relapse, but effective immunotherapeutic strategies...
Helicobacter pylori (H. pylori) is a common pathogen that has co-evolved with the human host for approximately 100,000 years; however, our understanding of its population structure remains limited. Furthermore, detailed characteristics virulence factors and antibiotic resistance H. are not yet fully elucidated. In this study, we curated global genome dataset 4067 isolates from 76 countries explored characteristics, including genetic structure, factors, resistance. We used three approaches...
Liver metastasis represents one of the most frequent malignant diseases with no effective treatment. Functional reprogramming Kupffer cells (KCs), largest population hepatic macrophages, holds promise for treating liver cancer, but remains seldom exploited. Taking advantage superior capacity KCs to capture circulating bacteria, we report that a single administration attenuated Escherichia coli producing clustered regularly interspersed short palindromic repeats CasΦ (CRISPR/CasΦ) machinery...
Abstract Background Neutrophil extracellular traps (NETs), antibacterial weapons of neutrophils (NEs), have been found to play a crucial role in cancer metastasis recent years. More and more research is focusing on anti-NETs. However, almost all anti-NETs treatments limitations such as large side effects limited efficacy. Therefore, exploring new therapeutic strategies long-term goal. Results The transmembrane protein coiled-coil domain containing 25 (CCDC25) tumor cell membranes can bind...
Characterized by progressive degeneration of retinal ganglion cells (RGCs) and vision loss, glaucoma is the primary cause irreversible blindness, incurable affecting over 78 million patients. However, pathogenic mechanisms leading to glaucoma-induced RGC loss are incompletely understood. Unexpectedly, we found that cGAS-STING (2'3'-cyclic GMP-AMP-stimulator interferon genes) signaling, which surveils displaced double-stranded DNA (dsDNA) in cytosol initiates innate immune responses, was...
Inflammatory bowel disease (IBD) is a multifaceted and recurrent immune disorder that occurs in the gastrointestinal tract. Betaine natural compound exerts beneficial anti-inflammatory effects. However, role of betaine protecting IBD still unclear. Therefore, aim our study was to investigate effect dextran sulfate sodium (DSS)-induced colitis. The results showed greatly increased body weight decreased activity index score DSS-treated mice. Furthermore, effectively downregulated protein...
Abstract Oncolytic bacteria are the most promising tumor target vector. Questions also remain regarding finding a balance between therapeutic efficacy and safety of oncolytic bacteria. The critical measure how this is maintained improvement in colonization. Attenuated Salmonella typhimurium (VNP20009) as only strain to be evaluated clinical trial potential bacterium. A delivery system with controlled release VNP after being loaded into neutrophils, which significantly increases...
Abstract Background Ticks serve as vectors for a diverse array of pathogens, including viruses responsible both human and livestock diseases. Symbiotic bacteria hold significant potential controlling tick-borne disease. However, the alteration tick gut bacterial community in response to pathogen infection has not been analyzed any viruses. Here, impact severe fever with thrombocytopenia syndrome virus (SFTSV) on diversity Haemaphysalis longicornis is investigated. Methods Unfed females were...
Abstract Lung cancer is a leading cause of cancer-related mortality globally, with dismal 5-year survival rate, particularly for Adenocarcinoma (LUAD). Mechanical changes within the tumor microenvironment, such as extracellular matrix (ECM) remodeling and fibroblast activity, play pivotal roles in progression metastasis. However, specific impact basement membrane (BM) on mechanical characteristics LUAD remains unclear. This study aims to identify BM genes influencing internal stress tumors,...
Clostridium difficile is a well-known nosocomial infectious pathogen. Research on C. infection has primarily focused strains such as the hypervirulent PCR ribotype 027 (sequence type 1 [ST1]) emerging in Europe and North America. However, other new ribotypes some countries have attracted attention, 17 (ST37) Asia Latin We collected 70 sequenced their toxin genes, tcdA tcdB. Multilocus sequence typing (MLST) was used to study population structure. In addition, and/or tcdB sequences of 25...
Atmospheric elements can cause harmful effects on air quality and human health. Despite extensive research PM2.5, there remains a limited understanding of the seasonal variations, origins, associated health risks specific in urban areas North China Plain. PM2.5 samples across four seasons were collected to investigate provenance, 18 Liaocheng. The concentrations total detected (TDEs) exhibited distinct patterns, with biggest values occurring winter, followed by spring, autumn, summer. Fe,...
The approved intravenous adeno-associated virus (AAV) therapies are limited by the widespread prevalence of pre-existing anti-AAV antibodies in general population, which known to restrict patients' ability receive gene therapy and limit transfection efficacy vivo. To address this challenge, we have developed a novel recombinant human immunoglobulin G degrading enzyme KJ103, characterized low immunogenicity clinical value for elimination transfer. Herein, conducted two randomized, blinded,...
Triple-negative breast cancer (TNBC) poses a significant challenge due to its high mortality rates, primarily attributed resistance against chemotherapy regimens containing taxanes like paclitaxel. Thus, developing combinatorial strategies override is pressing need. By taking advantage of library screening with various kinase inhibitors, we found that the small-molecule inhibitor enzastaurin targeting protein C (PKC) could overcome in TNBC cells. Mechanistically, dual treatment paclitaxel...