A5086787817- Mechanisms of cancer metastasis
- Cancer-related gene regulation
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Cancer Research and Treatments
- Resilience and Mental Health
- Meta-analysis and systematic reviews
- Lung Cancer Diagnosis and Treatment
- Click Chemistry and Applications
- Epigenetics and DNA Methylation
- Mental Health and Well-being
- Eicosanoids and Hypertension Pharmacology
- Clinical Reasoning and Diagnostic Skills
- Cardiac, Anesthesia and Surgical Outcomes
- Thyroid and Parathyroid Surgery
- Sympathectomy and Hyperhidrosis Treatments
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Artificial Intelligence in Healthcare and Education
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
Guilin Medical University
2025
Sun Yat-sen University
2024-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2024-2025
Qingdao University
2025
Qingdao Municipal Hospital
2025
Xiamen University
2025
Fujian Provincial Cancer Hospital
2024
The widespread use of androgen receptor (AR) signaling inhibitors has led to an increased incidence AR-negative castration-resistant prostate cancer (CRPC), limiting effective treatment and patient survival. A more comprehensive understanding the molecular mechanisms supporting CRPC could reveal therapeutic vulnerabilities improve treatment. This study showed that transcription factor nuclear I/B (NFIB) was upregulated in with tumors cell lines positively associated epithelial-to-mesenchymal...
Metastasis is the primary cause for treatment failure and poor prognosis in patients with triple-negative breast cancer (TNBC). Macroautophagy/autophagy plays a crucial role tumor growth metastasis. Genetic or epigenetic regulation of autophagy-related factors alters autophagy levels, which subsequently promotes progression affects therapeutic effectiveness. However, molecular basis transcriptional TNBC poorly understood. In this study, we reveal histone methyltransferase NSD2/WHSC1 (nuclear...
This study aimed to investigate the impact of Watson's Caring Model in Nursing (WCMN) on self-esteem, depression, resilience, quality life, and patient satisfaction as well determine potential outcome differences between patients receiving this personalised nursing care model those provided with standard care. retrospective included 113 who underwent radical prostatectomy at our hospital from January 2023 June 2023. According type received, were categorised into a traditional group (n = 67)...
Abstract Prostate cancer frequently progresses to castration‐resistant prostate (CRPC) following androgen deprivation therapy, presenting a significant clinical challenge. Targeting tumor metabolism, particularly mitochondrial pathways, offers promising strategy for overcoming CRPC. The modification of melatonin (Mel) triphenylphosphonium (TPP) cation‐targeted mitochondria–melatonin (Mito–Mel) significantly increases its potency by over 1000‐fold. Mito–Mel selectively targets mitochondria,...
<div>Abstract<p>The widespread use of androgen receptor (AR) signaling inhibitors has led to an increased incidence AR-negative castration-resistant prostate cancer (CRPC), limiting effective treatment and patient survival. A more comprehensive understanding the molecular mechanisms supporting CRPC could reveal therapeutic vulnerabilities improve treatment. This study showed that transcription factor nuclear I/B (NFIB) was upregulated in with tumors cell lines positively...
<div>Abstract<p>The widespread use of androgen receptor (AR) signaling inhibitors has led to an increased incidence AR-negative castration-resistant prostate cancer (CRPC), limiting effective treatment and patient survival. A more comprehensive understanding the molecular mechanisms supporting CRPC could reveal therapeutic vulnerabilities improve treatment. This study showed that transcription factor nuclear I/B (NFIB) was upregulated in with tumors cell lines positively...
<p>This PDF contais Supplementary Figures 1-4.</p>
<p>This PDF contais Supplementary Figures 1-4.</p>
Osimertinib, a third-generation tyrosine kinase inhibitor (TKI), has been authorized for use in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). This study aimed to evaluate the effectiveness and safety of neoadjuvant osimertinib individuals resectable locally advanced NSCLC harboring EGFR mutation. Ten centers located mainland China took part single-arm, real-world, multicenter retrospective (registration number: ChiCTR2100049954). Enrollment...