A5109695948- Mechanisms of cancer metastasis
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Prostate Cancer Treatment and Research
- Circular RNAs in diseases
- Eicosanoids and Hypertension Pharmacology
- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
Sun Yat-sen University
2024-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2024-2025
The widespread use of androgen receptor (AR) signaling inhibitors has led to an increased incidence AR-negative castration-resistant prostate cancer (CRPC), limiting effective treatment and patient survival. A more comprehensive understanding the molecular mechanisms supporting CRPC could reveal therapeutic vulnerabilities improve treatment. This study showed that transcription factor nuclear I/B (NFIB) was upregulated in with tumors cell lines positively associated epithelial-to-mesenchymal...
Abstract Prostate cancer frequently progresses to castration‐resistant prostate (CRPC) following androgen deprivation therapy, presenting a significant clinical challenge. Targeting tumor metabolism, particularly mitochondrial pathways, offers promising strategy for overcoming CRPC. The modification of melatonin (Mel) triphenylphosphonium (TPP) cation‐targeted mitochondria–melatonin (Mito–Mel) significantly increases its potency by over 1000‐fold. Mito–Mel selectively targets mitochondria,...
<div>Abstract<p>The widespread use of androgen receptor (AR) signaling inhibitors has led to an increased incidence AR-negative castration-resistant prostate cancer (CRPC), limiting effective treatment and patient survival. A more comprehensive understanding the molecular mechanisms supporting CRPC could reveal therapeutic vulnerabilities improve treatment. This study showed that transcription factor nuclear I/B (NFIB) was upregulated in with tumors cell lines positively...
<div>Abstract<p>The widespread use of androgen receptor (AR) signaling inhibitors has led to an increased incidence AR-negative castration-resistant prostate cancer (CRPC), limiting effective treatment and patient survival. A more comprehensive understanding the molecular mechanisms supporting CRPC could reveal therapeutic vulnerabilities improve treatment. This study showed that transcription factor nuclear I/B (NFIB) was upregulated in with tumors cell lines positively...
<p>This PDF contais Supplementary Figures 1-4.</p>
<p>This PDF contais Supplementary Figures 1-4.</p>