A5100382796- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Fuel Cells and Related Materials
- PI3K/AKT/mTOR signaling in cancer
- Chronic Lymphocytic Leukemia Research
- Electrocatalysts for Energy Conversion
- Neurological Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Biliary and Gastrointestinal Fistulas
- Lung Cancer Diagnosis and Treatment
- Tuberous Sclerosis Complex Research
- Meat and Animal Product Quality
- Virus-based gene therapy research
- Intracerebral and Subarachnoid Hemorrhage Research
- Metastasis and carcinoma case studies
- Sarcoma Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Cancer-related molecular mechanisms research
- Receptor Mechanisms and Signaling
- Virology and Viral Diseases
- Esophageal Cancer Research and Treatment
- Viral Infections and Vectors
- Diet and metabolism studies
National Institute for Viral Disease Control and Prevention
2011-2025
Zhejiang A & F University
2022-2025
East China Normal University
2025
Northern Jiangsu People's Hospital
2016-2024
Xian Yang Central Hospital
2024
Suzhou Institute of Trade & Commerce
2024
Oregon Health & Science University
2005-2024
Clinical Trials New Zealand
2024
Tauranga Hospital
2024
Suzhou Municipal Hospital
2024
ABSTRACT Growing concern over food security has drawn worldwide scholarly attention. Addressing issues highlights the vulnerability of agricultural yield to complexity agriculture inputs. Therefore, this study considers intricacies cultivation inputs and their effect on cereal production across 20 developing Asian countries from 1990 2022. First, advanced machine learning algorithms are employed investigate combined impact farming Product Complexity Index yields. Second, Granger causality...
Although the penetration of electric vehicles (EVs) in distribution networks can improve energy saving and emission reduction effects, its random uncertain nature limits ability to accept load EVs. To this end, establishing a profile model EV charging stations accurately reasonably is great significance planning, operation scheduling power system. Traditional generation methods for profiles rely too much on experience, need set up probability advance. In paper, we propose data-driven...
Metabolomics provide a promising tool to understand the pathogenesis and identify novel biomarkers of dementia. This study aimed determine circulating metabolites associated with incident dementia in Chinese cohort, whether selected metabolite panel could predict dementia.Thirty-eight baseline serum were profiled by nuclear magnetic resonance 1440 dementia-free participants followed 5 years Shanghai Aging Study.Higher levels glutamine O-acetyl-glycoproteins increased risk dementia, whereas...
Major gene effects on traits associated with substance use disorders are rare. Previous findings in methamphetamine drinking (MADR) lines of mice, bred for high or low voluntary MA intake, and null mutants demonstrate a major impact the trace amine-associated receptor 1 (Taar1) triad MA-related traits: consumption, MA-induced conditioned taste aversion hypothermia. While inbred strains fundamentally genetically stable, rare spontaneous mutations can become fixed result new aberrant...
Individual cerebral small vessel disease (CSVD) may cause cognitive decline. However, the association between total burden of CSVD and deterioration in general population remains unclear. We aimed to determine whether score is associated with performance change an d incident dementia population. In longitudinal population-based Taizhou Imaging Study, 556 participants free neurological disorders underwent brain MRI neuropsychological testing at baseline. A 456 were followed up for a mean...
While dried laver serves as an important raw ingredient for seaweed snacks, the microbial quality and safety risks associated with preparation processing of have not been well studied. In this project, three commercial plants were sampled from 2020 to 2022. Results indicated that current washing two-step drying process increased loads in laver. The total aerobic plate count (APC), coliform, mold counts ranged 7.34 7.91, 2.12 3.87, 1.65 3.87 Log CFU/g respectively. study further explored...
Gait disturbance is considered to be a significant clinical manifestation of cerebral small vessel disease (CSVD).We aimed investigate the association between different imaging markers CSVD or total burden and gait in community-dwelling population.In cross-sectional Taizhou Imaging Study (TIS), 314 participants free neurological disorders underwent MRI scanning assessment with quantitative wearable devices as well rating scales.In linear regression, after adjustment for demographics vascular...
Background Colorectal cancer (CRC) is a malignant tumor in the digestive tract. Increasing evidence indicated that chemoresistance leads to poor prognosis of CRC. Herein, we aimed uncover potential mechanism by which long intergenic noncoding RNA-1871 (LINC01871) affects CRC cells. Methods Relative level LINC01871 tissues was assessed reverse transcription quantitative PCR (RT-qPCR). Kaplan–Meier analysis conducted determine relevance and patients. Cell Counting Kit-8 (CCK-8) colony...
In China, rubella vaccination was introduced into the national immunization program in 2008, and a epidemic occurred same year. order to know whether changes genotypic distribution of viruses have postvaccination era, we investigate detail epidemiological profile China estimate evolutionary rate, molecular clock phylogeny, demographic history predominant virus genotypes circulating using Bayesian Markov chain Monte Carlo phylodynamic analyses. 1E found be genotype since its initial isolation...
Aims: We aimed to examine the associations of four extracranial artery indicators with cerebral small vessel disease (CSVD) and its total burden.
The approved intravenous adeno-associated virus (AAV) therapies are limited by the widespread prevalence of pre-existing anti-AAV antibodies in general population, which known to restrict patients' ability receive gene therapy and limit transfection efficacy vivo. To address this challenge, we have developed a novel recombinant human immunoglobulin G degrading enzyme KJ103, characterized low immunogenicity clinical value for elimination transfer. Herein, conducted two randomized, blinded,...
Chronic pulmonary aspergillosis is a common disease of the respiratory system, with hemoptysis being most frequent cause death in such patients. This article reports case chronic complicated by massive hemoptysis. The patient exhibited abnormal changes vascular anatomy. A dual-circulation approach, involving both and systemic circulations, was adopted, punctures performed via femoral vein, artery, radial procedure successfully completed. Preoperative CT angiography arteries, veins, bronchial...
Intelligence encompasses various abilities, including logical reasoning, comprehension, self-awareness, learning, planning, creativity, and problem-solving. Extensive research practical experience suggest that there are sex differences in intellectual development, with females typically maturing earlier than males. However, the key genes molecular network mechanisms underlying these development remain unclear. To date, Genome-Wide Association Studies (GWAS) have identified 507 significantly...
Binge/crash cycles of methamphetamine (MA) use are frequently reported by individuals suffering from MA disorders. A binge is self-reported as multiple daily doses that commonly accumulate to 800 mg/day (~10 mg/kg/day for a 170 pound human). genetic animal model with similar vulnerability binge-level intake missing. We used selectively bred high drinking (MAHDR) and low (MALDR) mouse lines determine whether several procedural variations would result in intake. Data were also collected two...
Cerebral microbleeds (CMBs) are considered to be risk factors for cognitive dysfunction. The specific pathology and clinical manifestations of CMBs different based on their locations. We investigated the association between at locations dysfunction explored potential underlying pathways in a rural Han Chinese population. used baseline data from 562 community-dwelling adults (55–65 years old) Taizhou Imaging Study 2013 2015. All individuals underwent multimodal brain magnetic resonance...
Introduction: Bruton's tyrosine kinase (BTK) inhibitors have long been known in the treatment of B-cell malignancies. Recently, BTK also become promising novel reagents for prostate cancer. The current study was designed to investigate expression cancer tissues comparison with benign hyperplasia and effect inhibitor on cell proliferation, migration invasion. Methods: assessed by immunohistochemistry; invasion lines (DU145 PC3) were Transwell wound-healing assay; proliferation using MTT assay...
Transdermal cannabinoids may provide better safety and bioavailability profiles compared with other routes of administration. This single-arm, open-label study investigated a novel topical transdermal delivery system on the pharmacokinetics cannabidiol (CBD) tetrahydrocannabinol (THC). Participants were 39.5 ± 7.37 years old healthy, based review by Medical Director. Blood was collected pre-dose 10, 20, 30, 45 min, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 12 h after application 100 mg CBD:100 THC....