A5049552841- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Cutaneous lymphoproliferative disorders research
- Acute Lymphoblastic Leukemia research
- Histiocytic Disorders and Treatments
- Glioma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- T-cell and Retrovirus Studies
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
- Neuroendocrine Tumor Research Advances
- Vascular Tumors and Angiosarcomas
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Tumors and Oncological Cases
- Parvovirus B19 Infection Studies
- Sarcoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
Jacksonville College
2016-2025
Mayo Clinic in Florida
2016-2025
WinnMed
2015-2024
Mayo Clinic Hospital
2020-2021
Jacksonville University
2013-2021
Affiliated Hospital of Youjiang Medical University for Nationalities
2021
Maulana Azad Medical College
2021
Mayo Clinic
2010-2014
University of Minnesota Rochester
2013
Mayo Clinic in Arizona
2013
Lymphomatoid granulomatosis (LYG) is a rare angiocentric and angiodestructive Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorder. It hypothesized that these patients have dysregulated immune surveillance of EBV. We reviewed the biopsies 55 with LYG who were referred for prospective trial at National Cancer Institute (1995 to 2010) evaluated histologic, immunohistochemical, in situ hybridization, molecular findings conjunction clinical information. Grading lesions was...
Systemic anaplastic large cell lymphomas (ALCLs) are classified into ALK-positive and ALK-negative types. We recently reported that ALCLs genetically heterogenous. The largest subset, representing 30% of cases, had rearrangements the DUSP22 locus. These cases favorable outcomes similar to ALCL, superior other ALCLs. Here, we examined morphologic features these in more detail. First, conducted blinded review hematoxylin eosin slides 108 from our previous study, scoring for presence 3...
The anti-CD52 antibody alemtuzumab has been explored as a novel targeted therapy in T cell malignancies. To assess the suitability of therapy, we carried out comprehensive study CD52 expression using flow cytometry (FC) 78 untreated patients diagnosed with mature T/natural killer (NK) neoplasms, including 34 adult leukaemia/lymphomas (ATLL), two anaplastic large lymphomas (ALCL), three angioimmunoblastic (AITL), 16 cutaneous (CTCL), four extra-nodal T/NK (ENT/NKCL), hepatosplenic (HSTCL), 13...
Malignant histiocytosis (MH) is an extremely rare neoplasm of the macrophage-dendritic cell lineage. We report clinical characteristics, molecular aberrations, treatments, and outcomes patients with MH seen at two referral centers from January 2000 to May 2023. identified 43 MH, which 26 had histiocytic sarcoma (MH-H), 9 interdigitating dendritic (MH-IDC), 8 Langerhans (MH-LC). The median age diagnosis was 61 years (range, 3-83). Thirty-three (77%) multifocal disease, while 10 unifocal...
Abstract We conducted a surveillance epidemiology and end results ( SEER )‐based analysis to describe the incidence characteristics of second primary acute lymphoblastic leukemia sALL ) among adults (≥18 years) with history malignancies (1M). Standardized ratios SIR s) cases were calculated by site 1M stage. also evaluated differences in 5‐year survival age, site, extent 1M, latency after evidence underlying racial/ethnic disparity. identified 10,956 patients de‐novo/primary (1 ALL 772 ....
Abstract Increased angiogenesis and tumor-induced immune evasion are two mechanisms by which clear cell renal carcinoma (ccRCC) proliferate metastasize; however, the relationship between these pathways in human ccRCC is poorly understood. We conducted a nested case–control study using 98 archived tumor samples from patients diagnosed with primary 1990 2006, half of were identified immunohistochemistry (IHC) as either programmed death ligand 1 (PDL-1)–positive or PDL-1–negative. RNAs...
Rosai-Dorfman disease (RDD) is a rare, benign histiocyte disorder originally described by Rosai and Dorfman in 1969 as sinus histiocytosis with massive lymphadenopathy. It most typically presents massive, painless cervical lymphadenopathy, it often found adolescents young adults. Extranodal involvement common feature of RDD may occur more than 40% patients. Less commonly, the can be seen bone. There are scattered case reports discussing use radiotherapy treatment RDD. Here, we present...
Summary CD38 is expressed on Waldenström macroglobulinaemia (WM) cells, but its role as a therapeutic target remains undefined. With recent approval of the anti‐CD38 monoclonal antibody, daratumumab (Dara), we hypothesized that blocking would be lethal to WM cells. In vitro Dara treatment cells (including ibrutinib‐resistant lines) elicited antibody‐dependent cellular cytotoxicity (ADCC), complement‐dependent (CDC), cell phagocytosis (ADCP) and direct apoptosis. vivo , was well tolerated...
Intravascular lymphoma (IVL) is a rare extranodal non-Hodgkin lymphoma. We performed retrospective analysis of 55 IVL patients who were treated at our institution 2003-2018. Median age diagnosis was 68 years, and 64% males. The most frequent presenting symptoms skin rash 43% weight loss 30%. MRI brain on with CNS involvement (CNS-IVL) showed multifocal in 76% (13/17). 89% (17/19) non-CNS-IVL abnormal FDG-PET had biopsy an avid lesion resulting definitive diagnosis. top diagnostic site the...
The majority of endometrial endometrioid adenocarcinomas involving the cervix have tumor morphology that is similar in endometrium and endocervix. There are, however, some cases which endocervix different from carcinoma, it more invasive than or invasion only occurs while there no minimal myometrial invasion. goal this study was to investigate whether tumors are 2 independent primaries by hematoxylin eosin stain, immunohistochemistry (IHC), human papillomavirus (HPV) DNA situ hybridization,...