A5015738994- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Renal Diseases and Glomerulopathies
- Forest Insect Ecology and Management
- Retinoids in leukemia and cellular processes
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Biochemical Acid Research Studies
- Cholesterol and Lipid Metabolism
- Insect and Arachnid Ecology and Behavior
- Protist diversity and phylogeny
- RNA modifications and cancer
- Genetic and Kidney Cyst Diseases
- Cancer-related gene regulation
- Acute Myeloid Leukemia Research
- Renal and related cancers
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Plant and animal studies
- Metabolism, Diabetes, and Cancer
- Lepidoptera: Biology and Taxonomy
- Protein Degradation and Inhibitors
- Genetic Syndromes and Imprinting
Jeonbuk National University
2011-2025
Korea Advanced Institute of Science and Technology
2021-2025
Boston Children's Hospital
2015-2023
Harvard University
2003-2023
Yonsei University
2009-2021
Korea Institute of Ceramic Engineering and Technology
2017-2021
Korea Forest Service
2013-2021
Kyungpook National University Hospital
2019
Brigham and Women's Hospital
2017
Catholic University of Korea
2013
Steroid-resistant nephrotic syndrome (SRNS) causes 15% of chronic kidney disease cases. A mutation in 1 over 40 monogenic genes can be detected approximately 30% individuals with SRNS whose symptoms manifest before 25 years age. However, many patients, the genetic etiology remains unknown. Here, we have performed whole exome sequencing to identify recessive SRNS. In 7 families and facultative ichthyosis, adrenal insufficiency, immunodeficiency, neurological defects, identified 9 different...
An injectable, heparin-based hydrogel system with the potential to be gelled cells was developed. First, heparin modified have thiol groups by modification of carboxylic cysteamine using carbodiimide chemistry. Thiol functionalization controlled from 10% 60% available COOH groups, and retained bioactivity heparin, characterized its binding affinity antithrombin III, decreased increasing functionalization. Then, thiol-functionalized reacted poly(ethylene glycol) diacrylate form a hydrogel....
The lack of an appropriate preclinical model metabolic dysfunction-associated steatotic liver disease (MASLD) that recapitulates the whole spectrum impedes exploration pathophysiology and development effective treatment strategies. Here, we develop a mouse (Streptozotocin with high-fat diet, STZ + HFD) gradually develops fatty liver, steatohepatitis (MASH), hepatic fibrosis, hepatocellular carcinoma (HCC) in context dysfunction. transcriptomic features HFD mice closely reflect those patients...
Abstract The pharmacological manipulation of liver X receptors (LXRs) has been an attractive therapeutic strategy for atherosclerosis treatment as they control reverse cholesterol transport and inflammatory response. This study presents the development efficacy nanoparticles (NPs) incorporating synthetic LXR agonist GW3965 (GW) in targeting atherosclerotic lesions. Collagen IV (Col IV) ligands are employed to functionalize NPs improve plaque, formulation parameters such length polyethylene...
Positive pressure mechanical ventilation has significant systemic effects, but the effects associated with ventilator-induced lung injury (VILI) are unexplored. We hypothesized that VILI would cause microvascular leak is dependent on nitric oxide synthase (NOS) expression. Rats were ventilated room air at 85 breaths/minute for 2 hours either VT 7 or 20 ml/kg. Kidney leak, which was assessed by measuring 24-hour urine protein and Evans blue dye, used as a marker of leak. A occurred in both...
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FBI-1 (also called Pokemon/ZBTB7A) is a BTB/POZ-domain Krüppel-like zinc-finger transcription factor. Recently, was characterized as proto-oncogenic protein, which represses tumor suppressor ARF gene transcription. The expression of increased in many cancer tissues. We found that potently the Rb gene, important cell cycle arrest. binds to four GC-rich promoter elements (FREs) located at bp –308 –188 region. also contains two Sp1 binding sites: GC-box 1 (bp –65 –56) and 2 –18 –9), latter...
FBI-1 (Pokemon/ZBTB7A) is a proto-oncogenic transcription factor of the BTB/POZ (bric-à-brac, tramtrack, and broad complex pox virus zinc finger) domain family. Recent evidence suggested that might be involved in adipogenic gene expression. Coincidentally, expression fatty-acid synthase (FASN) genes are often increased cancer immortalized cells. Both FASN important cell proliferation. SREBP-1 major regulator many genes, (sterol-responsive element (SRE)-binding protein 1) interact with each...
Aberrant transcriptional repression through chromatin remodeling and histone deacetylation has been postulated as the driving force for tumorigenesis. FBI-1 (formerly called Pokemon) is a member of POK family repressors. Recently, was characterized critical oncogenic factor that specifically represses transcription tumor suppressor gene ARF, potentially leading indirectly to p53 inactivation. Our investigations on pathway revealed Hdm2 (human analogue mouse double minute oncogene), p21CIP1...
Significance Statement ADCK4 mutations generally manifest as steroid-resistant nephrotic syndrome, and cause coenzyme Q 10 (CoQ ) deficiency. However, ADCK4’s function remains obscure. Using mouse cell models, the authors demonstrated that podocyte-specific Adck4 deletion in mice significantly reduced survival caused severe FSGS, effects were prevented by treatment with 2,4-dihydroxybenzoic acid (2,4-diHB), a CoQ precursor analogue. ADCK4-knockout podocytes exhibited level defects...
Liver fibrosis is characterized by an excessive accumulation of extracellular matrix components, leading to the distortion liver architecture and function. Recent studies have shown that antagonizing 5-hydroxytryptamine receptor 2B (5HT2B) stimulates apoptosis activated hepatic stellate cells inhibits their proliferation while concurrently regressing hepatocyte proliferation. In this study, we present compound 19c, which demonstrates promising efficacy both in vitro vivo. 19c showed robust...
We found that ZBTB2, a POK family transcription factor, is potent repressor of the ARF-HDM2-p53-p21 pathway important in cell cycle regulation. ZBTB2 repressed ARF, p53, and p21 genes, but activated HDM2 gene. In particular, gene by acting on two distal p53 binding elements proximal Sp1 GC-box 5/6 elements. directly interacted with via its POZ domain zinc fingers, which was repression activation Sp1. competed each other to inhibiting repressing p53. The domain, required for repression,...
Significance Transcription factor KAISO (POZ/BTB family protein, ZBTB33) expression is induced by genotoxic stress in a tumor suppressor p53-dependent manner. then interacts with p53 and the acetyltransferase p300 to modulate acetylation of imposing upon “code,” i.e., at K320 K382, inhibition K381. This coded shows increased DNA binding response elements promoters CDKN1A (cyclin-dependent kinase inhibitor 1) apoptosis genes, subsequently inducing cell cycle arrest potent apoptosis. critical...
Promyelocytic leukemia zinc finger (PLZF) is a transcription repressor that was initially isolated as fusion protein with retinoic acid receptor α. PLZF aberrantly overexpressed in various human solid tumors, such clear cell renal carcinoma, glioblastoma, and seminoma. causes cellular transformation of NIH3T3 cells increases proliferation several types. also tumor growth the mouse xenograft model. may stimulate by controlling expression genes p53 pathway (ARF, TP53, CDKN1A). We found can...
The tumour-suppressor gene CDKN1A (encoding p21Waf/Cip1) is thought to be epigenetically repressed in cancer cells. FBI-1 (ZBTB7A) a proto-oncogenic transcription factor repressing the alternative reading frame and p21WAF/CDKN1A genes of p53 pathway. interacts directly with MBD3 (methyl-CpG-binding domain protein 3) nucleus. We demonstrated that binds both non-methylated methylated DNA recruited promoter through its interaction FBI-1, where it enhances transcriptional repression by FBI-1....
Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of chronic kidney disease. Here, we identified recessive mutations in the gene encoding actin-binding protein advillin (AVIL) 3 unrelated families with SRNS. While all AVIL resulted marked loss its actin-bundling ability, truncation also disrupted colocalization F-actin, thereby leading to impaired actin binding and severing. Additionally, colocalized interacted phospholipase enzyme PLCE1 ARP2/3 actin-modulating complex....
The pinewood nematode (PWN), Bursaphelenchus xylophilus, is a causative agent of pine wilt disease (PWD). To date, although several molecular diagnostic methods have been developed, rapid on-site tools for detecting PWN in are limited. In this study, point care (POCD) method using recombinase polymerase amplification (RPA) assay was developed. This comprises quick gDNA extraction buffer (DAP buffer) the direct from and battery-mounted portable optical isothermal device (POID) detection PWD...
PLCE1 encodes phospholipase C epsilon, and its mutations cause recessive nephrotic syndrome. However, the mechanisms by which result in defects associated with glomerular function are not clear. To address this, we investigated of podocytes called epithelial cells, where pathogenesis syndrome converges. colocalized Rho GTPases glomeruli. Further, it interacted through pleckstrin homology domain Ras GTP-binding domains 1/2. Knockdown or knockout resulted decreased levels GTP-bound Rac1 Cdc42,...
Zinc finger MYND-type-containing 10 (ZMYND10), a cytoplasmic protein expressed in ciliated cells, causes primary ciliary dyskinesia (PCD) when mutated; however, its function is poorly understood. Therefore, this study, we examined the roles of ZMYND10 using Zmynd10–/–mice exhibiting typical PCD phenotypes, including hydrocephalus and laterality defects. In these mutants, morphology, number motile cilia, 9+2 axoneme structure were normal; inner outer dynein arms (IDA ODA, respectively)...
The aim of this study was to evaluate the prevalence, risk factors, and survival lung cancer in patients with idiopathic pulmonary fibrosis (IPF).IPF from tertiary hospitals consisted 1685 who had been diagnosed between 2003 2007. We reviewed their medical records retrospectively factors prognosis IPF patients.Among all IPF, 114 cases (6.8%) IPF. incidence 1.03 persons per 100 person-year (25 patients/2408 years). Most (73/114, 68.9%) were located IPF-associated areas; typically developed...
The NF-κB is found in almost all animal cell types and involved a myriad of cellular responses. Aberrant expression has been linked to cancer, inflammatory diseases improper development. Little known about transcriptional regulation the family member gene RelA/p65. Sp1 plays key role RelA/p65 gene. ZBTB2 represses transcription by inhibiting binding Sp1-binding GC-box proximal promoter (bp, −31 −21). Moreover, recent studies revealed that directly binds peroxisome proliferator-activated...