Significance Transcription factor KAISO (POZ/BTB family protein, ZBTB33) expression is induced by genotoxic stress in a tumor suppressor p53-dependent manner. then interacts with p53 and the acetyltransferase p300 to modulate acetylation of imposing upon “code,” i.e., at K320 K382, inhibition K381. This coded shows increased DNA binding response elements promoters CDKN1A (cyclin-dependent kinase inhibitor 1) apoptosis genes, subsequently inducing cell cycle arrest potent apoptosis. critical...

Internet gaming disorder (IGD) is a new that warrants further investigation, as recently noted in the research criteria of Diagnostic and Statistical Manual Mental Disorders, Fifth Edition. Offering controlled environments increase cue-induced craving, virtual reality cue-exposure therapy has been shown to be effective for some addiction disorders. To assess feasibility patients with IGD, this study aimed develop represent risk situations inducing effect cue reactivity. A total 64 male...

서 론우울증은 대표적인 정신질환 중 하나이며, 자살과 가장 밀 접한 관련을 가지는 질환으로 알려져 있다. 1) 주요 우울장애 환자는 16~40%에서 일생 동안 한 차례 이상의 자살을 시도 하며, 일반 인구에 비해 자살

Abstract Background Social anxiety disorder (SAD) is characterized by regarding social situations, avoidance of external stimuli, and negative self-beliefs. Virtual reality self-training (VRS) at home may be a good interim modality for reducing fears before formal treatment. This study aimed to find neurobiological evidence the therapeutic effect VRS. Methods Fifty-two patients with SAD were randomly assigned VRS or waiting list (WL) group. The group received an eight-session program 2...

Kr-pok (kidney cancer-related POZ domain and Krüppel-like protein) is a new proto-oncogenic POZ-domain transcription factor. Fatty acid synthase gene (FASN) encodes one of the key enzymes in fatty acids synthesis only enzyme that synthesizes cancer cells. Sp1 SREBP-1c are two major activators FASN. We investigated whether modulates FASN expression significantly decreased knockout murine embryonic fibroblasts. Coimmunoprecipitation, GST fusion protein pull-down, immunocytochemistry assays...

Transcriptional regulation by p53 is thought to play a role in its ability suppress tumorigenesis. However, there remain gaps understanding about how regulates transcription and disrupting this function may promote cancer. Here we report these processes for the kidney cancer-related gene KR-POK (ZBTB7C), POZ domain Krüppel-like zinc finger factor that found physically interact with p53. Murine embryonic fibroblasts isolated from genetically deficient mice (Kr-pok(-/-) MEFs) exhibited...

Abstract Social anxiety is a symptom widely prevalent among young adults, and when present in excess, can lead to maladaptive patterns of social behavior. Recent approaches that incorporate brain functional radiomic features machine learning have shown potential for predicting certain phenotypes or disorders from magnetic resonance images. In this study, we aimed predict the level adult participants by training models with resting-state including regional homogeneity, fractional amplitude...

Abstract We introduce a scheme for predicting photoresist sensitivity using machine learning (ML) work flow on the basis of previously reported experimental data. Different ML models, specifically Linear Regression, Kernel Ridge Gaussian Process Regressor, Random Forest and Multilayer Perceptron were evaluated to rapidly identify best prediction model. The experiment was carried out Google Colab platform Materials Simulation Toolkit Machine Learning Sci‐kit Learn. ensemble models utilized...

Social anxiety disorder (SAD) is a mental characterized by excessive in social situations. This study aimed to examine the alteration of resting-state functional connectivity SAD patients related virtual reality-based self-training (VRS) which enables exposure situations controlled environment. Fifty-two were randomly assigned experimental group who received VRS, or control did not. Self-report questionnaires and magnetic resonance imaging (fMRI) performed assess clinical symptoms analyze...

Purpose: This study aimed to explore how the grading system affected medical students’ academic performance based on their perceptions of learning environment and intrinsic motivation in context changing from norm-referenced A–F criterion-referenced honors/pass/fail grading.Methods: The involved 238 second-year students 2014 (n=127, grading) 2015 (n=111, at Yonsei University College Medicine Korea. Scores Dundee Ready Education Environment Measure, Academic Motivation Scale, Basic Medical...

The observer perspective causes patients with social anxiety disorder (SAD) to excessively inspect their performance and appearance. This study aimed investigate the neural basis of distorted self-face recognition in non-social situations SAD. Twenty SAD 20 age- gender-matched healthy controls participated this fMRI study. Data were acquired while participants performed a Composite Face Evaluation Task, during which they had press button indicating how much liked series self-faces,...

Background Excessive internet game use frequently leads to various physical, psychological, and social problems, gaming disorder (IGD) has become a serious public health issue worldwide. Recently, virtual reality (VR) therapy emerged as promising method increase psychological treatment motivation accessibility. However, few studies have examined the potential of VR technology for management IGD, content tailored IGD characteristics remains scarce. Objective This preliminary study aimed...

본 연구의 목적은 다문화청소년의 스트레스와 우울 및 가족탄력성과 인터넷게임중독과의 관계를 파악해 보고 우울과 인터넷게임중독에 대한 가족탄력성의 매개효과를 분석해보고자 한다. 연구대상은 다문화청소년 204명이며, 자료분석은 SPSS와 AMOS를 통해 기술통계, 상관관계와 구조모형방정식을 이용하였다. 연구 결과는 다음과 같다. 첫째, 우울은 인터넷게임중독과 유의한 정적 관계를, 가족탄력성은 부적 나타내었다. 둘째, 가족탄력성에 영향을, 영향을 주었다. 셋째, 인터넷게임중독간의 매개하는 효과가 나타났다. 가족탄력성을 간접적으로 미치는 것으로 따라서 가족탄력성 향상을 위해서는 청소년개인의 우울이 개입되어야 하며 인터넷게임중독예방을 위한 가족탄력성증진 프로그램 개발 시행이 요구된다. The purposes of this study were to find the correlation variables, and explore mediating role family resilience...

Abstract Background Functional communication is vital in many areas of daily life, and modifying dysfunctional has been emphasized various social areas, including family school. The present preliminary study addressed the feasibility a virtual reality (VR)-based interactive feedback program for modification communication. Methods Thirty-seven healthy young males completed psychological assessments associated with functional participated VR-based program, consisting three tasks ‘exploring...

The present study examined the cultural competence of university students on migrants and multicultural society in Korea. A total 11 living Seoul, Gyeonggido Chungcheondo, were selected for interview. participants provided their cognition, knowledge skill a variety issues related to Interview results indicated that perceived negative positive affects Korean prejudice about immigrants, thaught economic support as emergent policy, didn't experience society. They wanted take trip learning...

As the area of upland crops increase, it is become more important for farmers to understand status soil water at their own fields due key role proper irrigation. In order estimate daily balance and content with simple weather data irrigation records, we have developed model estimating content, called AFKAE0.5, verified its simulated results comparing change observed by profile moisture sensors. AFKAE0.5 has two hypothesis before establishing system. The first in 300 mm depth texture. And...

Abstract Background and aims Impulsiveness is an important factor in the pathophysiology of Internet gaming disorder (IGD), regional brain functions can be different depending on level impulsiveness. This study aimed to demonstrate that mechanisms are involved impulsiveness among patients with IGD. Methods Resting-state functional MRI data were obtained from 23 IGD high impulsivity, 27 low 22 healthy controls, seed-based connectivity was compared three groups. The seed regions ventromedial...

Enhancing subjective well-being is an effective way to improve mental health. This study aimed validate a virtual realitybased interactive feedback program as intervention tool for promoting well-being.Thirty-six males participated in this program, consisting of three tasks constructed based on the theories positive psychology: 'Experience-based problem recognition task', 'Future self-based success story expression and 'Strength task'. Participants rated visual analog scores associated with...