A5041738287- Heat shock proteins research
- Cancer-related Molecular Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Biomarkers in Disease Mechanisms
- Effects of Radiation Exposure
- Spaceflight effects on biology
- Ubiquitin and proteasome pathways
- Angiogenesis and VEGF in Cancer
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Circular RNAs in diseases
- Protease and Inhibitor Mechanisms
- Colorectal Cancer Treatments and Studies
- Electromagnetic Fields and Biological Effects
- Chemotherapy-induced cardiotoxicity and mitigation
- Lung Cancer Diagnosis and Treatment
- Galectins and Cancer Biology
- Colorectal Cancer Surgical Treatments
- Carcinogens and Genotoxicity Assessment
- Bee Products Chemical Analysis
- Healthcare and Venom Research
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Photoreceptor and optogenetics research
- Cancer-related molecular mechanisms research
Institute for Basic Science
2024
Yonsei University
2017-2020
Memorial Sloan Kettering Cancer Center
2019
Korea Institute of Radiological and Medical Sciences
2011-2016
Korea University
2011-2014
Radiation-induced pulmonary fibrosis (RIPF) is a late side effect of thoracic radiotherapy. The purpose our study was to gain further insight into the development RIPF.Here, we observed that irradiation mouse lungs induced collagen deposition, particularly around blood vessels, in early phase RIPF. Such deposition subsequently became evident throughout irradiated tissues. Accompanied by vascular EndMT (endothelial-to-mesenchymal transition) began develop RIPF, before appearance EMT...
The endothelial-to-mesenchymal transition (EndMT) contributes to cancer, fibrosis, and other pathologic processes. However, the underlying mechanisms are poorly understood. Endothelial HSP1 (HSPB1) protects against cellular stress has been implicated in cancer progression pulmonary fibrosis. In this study, we investigated role of HSPB1 mediating EndMT during development fibrosis lung cancer. silencing human endothelial cells accelerated emergence fibrotic phenotype after treatment with TGFβ...
Purpose: Radiation-induced cardiovascular disease is a potentially severe side-effect of thoracic radiotherapy treatment. Clinically, this delayed presents as form accelerated atherosclerosis several years after irradiation. As general endothelial dysfunction known to be an initiating event in radiation-induced vascular damage, we examined the effects radiation on cells atherosclerosis.
Radiation-induced lung fibrosis, the most serious effect of cancer radiotherapy on normal tissue, remains a major technical obstacle to broader application patients with cancer. This study describes use an image-guided irradiation system in mice mimicking stereotactic body (SBRT) examine molecular features chronic fibrotic response after radiation injury. MicroRNA (miR) array analysis injured pulmonary tissue identified set miRs whose expression was significantly increased damaged tissue. In...
Matrix metalloproteinases regulate pathophysiological events by processing matrix proteins and secreted proteins. Previously, we demonstrated that soluble heat shock protein B1 (HSPB1) is released primarily from endothelial cells (ECs) regulates angiogenesis via direct interaction with vascular growth factor (VEGF). Here report MMP9 can cleave HSPB1 release anti-angiogenic fragments, which play a key role in tumorprogression. We mapped the cleavage sites explored their physiological...