A5087131100- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- HIV/AIDS Research and Interventions
- Radiomics and Machine Learning in Medical Imaging
- HIV/AIDS drug development and treatment
- Tourism, Volunteerism, and Development
- HIV, Drug Use, Sexual Risk
- Cancer Cells and Metastasis
- Viral-associated cancers and disorders
- Social Sciences and Governance
- LGBTQ Health, Identity, and Policy
- Peptidase Inhibition and Analysis
- Workplace Spirituality and Leadership
- Cytomegalovirus and herpesvirus research
- Melanoma and MAPK Pathways
- Colorectal Cancer Screening and Detection
- Breast Lesions and Carcinomas
- Protease and Inhibitor Mechanisms
- Pancreatic and Hepatic Oncology Research
- HIV-related health complications and treatments
Memorial Sloan Kettering Cancer Center
2018-2024
University of Cape Town
2022
Montpellier Business School
2013-2014
Columbia University
2009-2013
Laboratoire d’Informatique et Systèmes
2013
University of Pittsburgh Medical Center
2013
University of Pittsburgh
2013
Ospedali Riuniti Umberto I
2003
Treatment Action Group
1997-1999
Adding modified FOLFOX6 (folinic acid, fluorouracil, and oxaliplatin) after chemoradiotherapy lengthening the chemoradiotherapy-to-surgery interval is associated with an increase in proportion of rectal cancer patients a pathological complete response.The purpose this study was to analyze disease-free overall survival.This nonrandomized phase II trial.The conducted at multiple institutions.Four sequential groups stage or III were included.All received 50 Gy radiation concurrent continuous...
Abstract Purpose: SMAD4 has shown promise in identifying patients with colorectal cancer at high risk of recurrence or death. Experimental Design: A discovery cohort and independent validation were classified by status. status immune infiltrate measurements tested for association recurrence-free survival (RFS). Patient-derived xenografts from SMAD4-deficient SMAD4-retained tumors used to examine chemoresistance. Results: The consisted 364 stage I–IV cancer. Median age diagnosis was 53 years....
Background MRI plays a crucial role in restaging locally advanced rectal cancer treated with total neoadjuvant therapy (TNT); however, prospective studies have not evaluated its ability to accurately select patients for nonoperative management. Purpose To evaluate the of predict oncologic outcomes and identify imaging features associated residual disease (RD) after TNT. Materials Methods This was secondary analysis Organ Preservation Rectal Adenocarcinoma (OPRA) trial, which randomized...
Abstract Background Total neoadjuvant therapy (TNT) improves tumor response in locally advanced rectal cancer (LARC) patients compared to chemoradiotherapy alone. The effect of TNT on patient survival has not been fully investigated. Materials and Methods This was a retrospective case series with LARC at comprehensive center. Three hundred eleven received (chemoRT) as the sole treatment planned adjuvant chemotherapy, 313 (induction fluorouracil oxaliplatin-based chemotherapy followed by...
Purpose: To describe cytomegalovirus (CMV) end-organ disease (EOD) rate in AIDS patients with low CD4+ cell count despite HAART who were enrolled a randomized, placebo-controlled trial of preemptive valganciclovir (VGCV) to prevent CMV EOD those viremia. Methods: Subjects (N = 338) HIV-infected <100 cells/mm3, plasma HIV RNA >400 copies/mL, and on stable or no HAART. All underwent DNA PCR testing every 8 weeks (Step 1); detectable randomized VGCV placebo 2). Results: Plasma was detected 68...
Abstract Background Prospective randomized trials have not yet identified baseline features predictive of organ preservation in locally advanced rectal cancers treated with total neoadjuvant therapy and a selective watch-and-wait strategy. Methods This was secondary analysis the OPRA trial, which patients stage II–III adenocarcinoma to receive either induction or consolidation therapy. Patients were recommended for mesorectal excision, watch wait based on clinical response at 8 ± 4 weeks...
Abstract Background Colorectal cancer is the second‐leading cause of cancer‐related mortality in United States and a leading worldwide. Loss SMAD4, critical tumor suppressor central node transforming growth factor‐beta superfamily, associated with worse outcomes for colorectal patients; however, it unknown whether an RNA‐based profile SMAD4 expression could be used to better identify high‐risk patients. Aim Identify gene expression‐based SMAD4‐modulated test its association patient outcome....
Abstract KRAS mutation in colorectal cancer is associated with aggressive tumor behavior through increased invasiveness and higher rates of lung metastases, but the biological mechanisms behind these features are not fully understood. In this study, we show that KRAS-mutant upregulates integrin α6β4 ERK/MEK signaling. Knocking-out β4 (ITGB4) specifically depleted expression resulted a reduction invasion migration ability cells. We also observed number area metastatic foci mice were injected...
Somatic mutations in the KRAS oncogene are associated with poor outcomes locally advanced rectal cancer but underlying biologic mechanisms not fully understood. We profiled mRNA 76 adenocarcinomas from patients that were enrolled a prospective clinical trial and investigated differences gene expression between mutant (KRAS-mt) KRAS-wild-type (KRAS-wt) patients. found KRAS-mt tumors display lower of genes related to tumor stroma remodeling extracellular matrix. validated our findings using...
609 Background: KRAS-mutant (KRAS mut ) colorectal cancers (CRCs) are associated with worse prognosis and resistance to therapy. We have previously shown that KRAS CRCs different transcriptomic signature of stromal immune-related genes compared KRAS-wild type wt tumors. Here, we validated the changes in tumor microenvironment mutation CRC guide design novel immunotherapy strategies. Methods: The expression immune markers (T cells, B macrophages, natural killer check ligands) were assessed...
This study aims to verify the relationship between perceived benefits and behavioral control on fintech adoption intention banking products services in Indonesia. quantitative uses technology acceptance model (TAM) approach theory of planned behavior (TPB). The sampling technique purposive sampling, with a sample size 545 respondents. data source used is primary data. Data were collected by distributing questionnaires built using Google Forms distributed through social media. analysis...
Abstract Rectal cancer (RC) is a challenging disease to treat that requires chemotherapy, radiation, and surgery optimize outcomes for individual patients. No accurate model of RC exists answer fundamental research questions relevant We established biorepository 32 patient-derived organoid cultures (tumoroids) from patients with primary, metastatic, or recurrent disease. tumoroids retained molecular features the tumors which they were derived, their ex vivo responses clinically chemotherapy...
576 Background: KRAS mutation ( mut ) is associated with aggressive biological behavior and resistance to chemoradiotherapy in colorectal cancer (CRC). The tumor microenvironment a critical component framing the of cancers. We have recently shown that modulates by reducing expression extracellular matrix (ECM) genes CRC. effect on integrins, epithelial cell receptors for ECM proteins, remains largely unknown. Here, we investigated impact integrin CRC beta 4 (ITGB4) phenotype. Methods:...
Abstract Objective Loss of SMAD4 is associated with worse outcomes for colorectal cancer patients. We used gene ontology and bioinformatics to identify an RNA-based SMAD4-modulated profile test its association patient outcome. Design Using a discovery dataset 250 patients, we analyzed expression BMP/Wnt target genes expression. Promoters the were interrogated SMAD-binding elements. 15 implicated three tested modulation by in patient-derived tumoroids. Expression was unsupervised hierarchical...
Orientation: Asset managers constructing an emerging market portfolio of stocks should, along with more traditional risk metrics, consider ESG data in their due diligence and investment decision-making processes.Research purpose: To determine whether a company's higher relative focus on incorporation results the observation lower levels share price return volatility, as predicted by EWMA GARCH models. Study motivation:Institutional investors wish to understand role that plays mitigating...