A5016541773- Colorectal Cancer Surgical Treatments
- Inflammatory Bowel Disease
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Microscopic Colitis
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Autoimmune and Inflammatory Disorders
- MicroRNA in disease regulation
- Anorectal Disease Treatments and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Cancer Research and Treatments
- Appendicitis Diagnosis and Management
- Cancer-related molecular mechanisms research
- Gastrointestinal disorders and treatments
- Enhanced Recovery After Surgery
- Stoma care and complications
- Gastrointestinal Tumor Research and Treatment
- Pelvic floor disorders treatments
- Lung Cancer Treatments and Mutations
Baylor University Medical Center
2020-2025
University of Huddersfield
2019-2025
Weill Cornell Medicine
2025
Digestive Care (United States)
2025
Cornell University
2025
Texas A&M University
2024
University of Brescia
2009-2024
Baylor Scott & White Health
2021
University of North Carolina at Chapel Hill
2017-2020
Baylor University
2020
This portion of the NCCN Guidelines for Colon Cancer focuses on use systemic therapy in metastatic disease. Considerations treatment selection among 32 different monotherapies and combination regimens up to 7 lines have included history, extent disease, goals treatment, efficacy toxicity profiles regimens, KRAS/NRAS mutational status, patient comorbidities preferences. Location primary tumor, BRAF mutation tumor microsatellite stability should also be considered decisions.
IMPORTANCEEvidence about the efficacy of laparoscopic resection rectal cancer is incomplete, particularly for patients with more advanced-stage disease.OBJECTIVE To determine whether noninferior to open resection, as determined by gross pathologic and histologic evaluation resected proctectomy specimen.DESIGN, SETTING, AND PARTICIPANTS A multicenter, balanced, noninferiority, randomized trial enrolled between October 2008 September 2013.The was conducted credentialed surgeons from 35...
To determine the disease-free survival (DFS) and recurrence after treatment of patients with rectal cancer open (OPEN) or laparoscopic (LAP) resection.This randomized clinical trial (ACOSOG [Alliance] Z6051), performed between 2008 2013, compared LAP OPEN resection stage II/III cancer, within 12 cm anal verge (T1-3, N0-2, M0) in who received neoadjuvant chemoradiotherapy. The rectum mesorectum were resected using instruments for dissection (included hybrid hand-assisted laparoscopic) under...
To document functional results in patients treated with an ileal pouch anal anastomosis (IPAA).The restorative proctocolectomy IPAA has become the procedure of choice for ulcerative colitis, yet long-term are not well known.We performed this prospective observational study 391 consecutive (56% male; mean age, 33.7 +/- 10.8 years; range, 12-66 years) who underwent between 1987 and 2002 (mean follow-up, 33.6 months; 0 to 180 months).The majority under elective circumstances a hand-sewn...
Adding modified FOLFOX6 (folinic acid, fluorouracil, and oxaliplatin) after chemoradiotherapy lengthening the chemoradiotherapy-to-surgery interval is associated with an increase in proportion of rectal cancer patients a pathological complete response.The purpose this study was to analyze disease-free overall survival.This nonrandomized phase II trial.The conducted at multiple institutions.Four sequential groups stage or III were included.All received 50 Gy radiation concurrent continuous...
Abstract Epidermal growth factor receptors (EGFR) contribute to colonic tumorigenesis in experimental models of colon cancer. We previously showed that EGFR was also required for tumor promotion by Western diet. The goal this study identify EGFR-regulated microRNAs diet-promoted tumorigenesis. Murine tumors from Egfrwt and hypomorphic Egfrwa2 mice were screened using micro RNA (miRNA) arrays miR-143 miR-145 changes confirmed Northern, real-time PCR, situ analysis. Rodent human sporadic...
miR-143 and miR-145 are believed to function as colon cancer tumor suppressors, they inhibit cell growth downregulated in sporadic colonic tumors. We speculated that might also be contribute malignant transformation of epithelium longstanding ulcerative colitis (UC).Biopsies were obtained 20 cm proximal the anus from individuals with quiescent UC normal controls. RNA proteins extracted measured. quantified by real-time polymerase chain reaction (PCR) was assessed situ hybridization. Putative...
Although bowel-sparing techniques have been published for treatment of Crohn's disease the small bowel because its relentless nature, extent resection in colitis is still a topic debate. This study was designed to prospectively evaluate long-term outcomes patients with isolated identify that may benefit from initial more aggressive resection.We identified 179 operated on primary colonic disease. They were divided into segmental colectomy, total abdominal and proctocolectomy groups, based...
Translation Network (SCOAP-CERTAIN) Collaborative V enous thromboembolism (VTE) prevention in hospitalized patients has been promoted as a patient safety priority by multitude of agencies. 1Despite the fact that colorectal surgery is one most commonly performed procedures, American College Chest Physicians' revised evidence-based guidelines regarding strategies to reduce VTE among surgical do not offer comprehensive recommendations for undergoing surgery. 2,3General recommended abdominal...
The impact of infliximab on the postoperative course patients with IBD is under debate.The aim this study was to evaluate influence perioperative outcomes in undergoing elective laparoscopic resection for IBD.This a retrospective analysis prospectively collected, institutional review board-approved database. SETTING, PATIENTS, INTERVENTIONS: Patients preoperative (infliximab group) were compared who did not receive (noninfliximab group).The short-term and long-term morbidity mortality rates...
Background Genetic studies support the scenario that Bos taurus domestication occurred in Near East during Neolithic transition about 10 thousand years (ky) ago, with likely exception of a minor secondary event Italy. However, despite proven effectiveness whole mitochondrial genome data providing valuable information concerning origin taurine cattle, until now no population surveys have been carried out at level mitogenomes local breeds from or surrounding areas. Egypt is close geographic...
BACKGROUND: Randomized controlled trials demonstrate the efficacy of arginine-enriched nutritional supplements (immunonutrition) in reducing complications after surgery. The effectiveness preoperative immunonutrition has not been evaluated a community setting. OBJECTIVE: This study aims to determine whether before elective colorectal surgery improves outcomes at large. DESIGN: is prospective cohort with propensity score–matched comparative evaluation. SETTINGS: was conducted Washington State...