A5068823540- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- MRI in cancer diagnosis
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Medical Imaging Techniques and Applications
- Melanoma and MAPK Pathways
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Radiation Dose and Imaging
- Diverticular Disease and Complications
- Intraperitoneal and Appendiceal Malignancies
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Advanced X-ray and CT Imaging
- Genetic factors in colorectal cancer
- Intestinal and Peritoneal Adhesions
- COVID-19 and healthcare impacts
- COVID-19 diagnosis using AI
Memorial Sloan Kettering Cancer Center
2016-2025
Universidade de São Paulo
2019-2024
Cornell University
2007-2021
NRG Oncology
2018-2021
Hospital Sírio-Libanês
2019
Memorial Hospital of South Bend
2012
Medical Education Institute
2010
Laboratory Imaging (Czechia)
2005
American Society of Echocardiography
2005
Singapore General Hospital
2003
Neoadjuvant chemotherapy and radiation followed by surgical resection of the rectum is a standard treatment for locally advanced rectal cancer. A subset cancer caused deficiency in mismatch repair. Because repair-deficient colorectal responsive to programmed death 1 (PD-1) blockade context metastatic disease, it was hypothesized that checkpoint could be effective patients with repair-deficient,
International challenges have become the de facto standard for comparative assessment of image analysis algorithms given a specific task. Segmentation is so far most widely investigated medical processing task, but various segmentation typically been organized in isolation, such that algorithm development was driven by need to tackle single clinical problem. We hypothesized method capable performing well on multiple tasks will generalize previously unseen task and potentially outperform...
Semantic segmentation of medical images aims to associate a pixel with label in image without human initialization. The success semantic algorithms is contingent on the availability high-quality imaging data corresponding labels provided by experts. We sought create large collection annotated datasets various clinically relevant anatomies available under open source license facilitate development algorithms. Such resource would allow: 1) objective assessment general-purpose methods through...
PURPOSE Prospective data on the efficacy of a watch-and-wait strategy to achieve organ preservation in patients with locally advanced rectal cancer treated total neoadjuvant therapy are limited. METHODS In this prospective, randomized phase II trial, we assessed outcomes 324 stage or III adenocarcinoma induction chemotherapy followed by chemoradiotherapy (INCT-CRT) consolidation (CRT-CNCT) and either mesorectal excision (TME) basis tumor response. Patients both groups received 4 months...
<h3>Importance</h3> Treatment of locally advanced rectal (LARC) cancer involves chemoradiation, surgery, and chemotherapy. The concept total neoadjuvant therapy (TNT), in which chemoradiation chemotherapy are administered prior to has been developed optimize delivery effective systemic aimed at micrometastases. <h3>Objective</h3> To compare the traditional approach preoperative (chemoRT) followed by postoperative adjuvant with more recent TNT for LARC. <h3>Design, Setting, Participants</h3>...
The watch-and-wait (WW) strategy aims to spare patients with rectal cancer unnecessary resection.To analyze the outcomes of WW among who had a clinical complete response neoadjuvant therapy.This retrospective case series analysis conducted at comprehensive center in New York included received diagnosis adenocarcinoma between January 1, 2006, and 31, 2015. median follow-up was 43 months. Data analyses were from June 2016, October 2018.Patients after completing therapy agreed active...
Although neoadjuvant chemoradiotherapy achieves low local recurrence rates in clinical stages II to III rectal cancer, it delays administration of optimal chemotherapy. We evaluated preoperative infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX)/bevacizumab with selective rather than consistent use chemoradiotherapy.Thirty-two patients cancer participated this single-center phase trial. All were candidates for anterior resection total mesorectal excision (TME). Patients receive...
Treatment of patients with non-metastatic, locally advanced rectal cancer (LARC) includes pre-operative chemoradiation, total mesorectal excision (TME) and post-operative adjuvant chemotherapy. This trimodality treatment provides local tumor control in most patients; but almost one-third ultimately die from distant metastasis. Most survivors experience significant impairment quality life (QoL), due primarily to removal the rectum. A current challenge lies identifying who could safely undergo...
Purpose To investigate the value of T2-weighted-based radiomics compared with qualitative assessment at T2-weighted imaging and diffusion-weighted (DW) for diagnosis clinical complete response in patients rectal cancer after neoadjuvant chemotherapy-radiation therapy (CRT). Materials Methods This retrospective study included 114 who underwent magnetic resonance (MR) CRT between March 2012 February 2016. Median age among women (47 114, 41%) was 55.9 years (interquartile range, 45.4-66.7...
BRAF-mutant metastatic colorectal cancer (mCRC) forms an aggressive subset of with minimal response to selective RAF inhibitors. Preclinical data show that reactivation EGFR signaling occurs in tumor cells treated inhibitors and the addition inhibitor enhances antitumor activity. These suggest combined therapy could be effective strategy for treating BRAF V600E mCRC.We undertook a pilot trial assess rate safety vemurafenib anti-EGFR antibody panitumumab patients mCRC. Patients received...
Pelvic radiation plus sensitizing chemotherapy with a fluoropyrimidine (chemoradiotherapy) before surgery is standard care for locally advanced rectal cancer in North America. Whether neoadjuvant fluorouracil, leucovorin, and oxaliplatin (FOLFOX) can be used lieu of chemoradiotherapy uncertain. Download PDF the Research Summary. We conducted multicenter, unblinded, noninferiority, randomized trial FOLFOX (with given only if primary tumor decreased size by <20% or was discontinued because...
Tumor regression grade (TRG) is a measure of histopathological response rectal cancer to neoadjuvant chemoradiation and associated with outcomes. Several TRG systems are used: Mandard (5,3-tier), Dowrak/Rödel Memorial Sloan Kettering Cancer Center (MSKCC), American Joint Committee on (AJCC) Staging. A single would assist in comparing results across institutions, designing future studies. In this study, the predictive accuracies various published classification schemes compared.Review...
<h3>Importance</h3> Total neoadjuvant therapy (TNT) is often used to downstage locally advanced rectal cancer (LARC) and decrease locoregional relapse; however, more than one-third of patients develop recurrent metastatic disease. As such, novel combinations are needed. <h3>Objective</h3> To assess whether the addition pembrolizumab during after chemoradiotherapy can lead an improvement in (NAR) score compared with treatment FOLFOX (5-fluorouracil, leucovorin, oxaliplatin) alone. <h3>Design,...
JCO
The standard of care for locally advanced rectal cancer in North America is neoadjuvant pelvic chemoradiation with fluorouracil (5FUCRT). Neoadjuvant chemotherapy and oxaliplatin (FOLFOX) an alternative that may spare patients the morbidity radiation. Understanding relative patient experiences these options necessary to inform treatment decisions.
Importance Assessing clinical tumor response following completion of total neoadjuvant therapy (TNT) in patients with locally advanced rectal cancer is paramount to select for watch-and-wait treatment. Objective To assess organ preservation (OP) and oncologic outcomes according grade. Design, Setting, Participants This was secondary analysis the Organ Preservation Patients Rectal Adenocarcinoma trial, a phase 2, nonblinded, multicenter, randomized trial. Randomization occurred between April...
Whole-body 18F-fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) imaging before and after induction therapy was prospectively evaluated in patients with esophageal cancer to determine whether changes PET images could measure response therapy.Between April 1997 1999, 39 (34 men five women; median age, 59 years; range, 36 76 years) were enrolled a single-institution clinical trial of staging, including PET, therapy, restaging esophagectomy. All undergoing esophagectomy (n = 17)...
PURPOSE: To evaluate the response, toxicity, survival, and quality of life in patients with unresectable or metastatic esophageal cancer treated weekly irinotecan cisplatin. PATIENTS AND METHODS: Thirty-five adenocarcinoma (23 patients) squamous cell carcinoma (12 were treated. No prior chemotherapy was allowed. The majority had bidimensionally measurable disease (34 each [97%]). Patients cisplatin 30 mg/m 2 65 , repeated for 4 weeks, followed by a 2-week rest period. Treatment recycled...