A5052448371- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Medical Imaging Techniques and Applications
- Colorectal Cancer Surgical Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- MRI in cancer diagnosis
- Radiation Therapy and Dosimetry
- Advanced MRI Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Advances in Oncology and Radiotherapy
- Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Advanced X-ray and CT Imaging
- Colorectal Cancer Screening and Detection
- Head and Neck Cancer Studies
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
Memorial Sloan Kettering Cancer Center
2016-2025
Cornell University
2022-2024
Weill Cornell Medicine
2023
Digital Health Cooperative Research Centre
2019-2022
Digital China Health (China)
2019-2022
Radiation Oncology Associates
2019
Columbia University
2003-2008
Park University
2008
Cancer Genetics (United States)
2003
Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in United States. A major challenge treatment remains patients’ advanced disease at diagnosis. The NCCN Guidelines for Adenocarcinoma provides recommendations diagnosis, evaluation, treatment, follow-up patients with pancreatic cancer. Although survival rates remain relatively unchanged, newer modalities including targeted therapies, provide hope improving patient outcomes. Sections manuscript have been...
The watch-and-wait (WW) strategy aims to spare patients with rectal cancer unnecessary resection.To analyze the outcomes of WW among who had a clinical complete response neoadjuvant therapy.This retrospective case series analysis conducted at comprehensive center in New York included received diagnosis adenocarcinoma between January 1, 2006, and 31, 2015. median follow-up was 43 months. Data analyses were from June 2016, October 2018.Patients after completing therapy agreed active...
Surgical resection has been considered the only curative option for patients with pancreatic cancer. Nonoperative local treatment options that can provide a similar benefit are needed. Emerging radiation techniques address organ motion have enabled doses to be given in inoperable disease.To determine association of hypofractionated ablative therapy (A-RT) survival locally advanced cancer (LAPC) treated novel planning and delivery technique.This cohort study included 119 consecutive A-RT...
A circulating tumor DNA (ctDNA) test to detect plasma Epstein-Barr viral can be used screen for early nasopharyngeal cancers; however, the reported sensitivity of ctDNA tests human papillomavirus (HPV)-associated cancers is modest. We assessed utility droplet digital polymerase chain reaction (ddPCR) early-stage HPV-associated using sequential HPV16 and HPV33 assays that account HPV subtype distribution sequence variants.We collected specimens from 97 HPV-positive patients with oropharyngeal...
At the root of most fatal malignancies are aberrantly activated transcriptional networks that drive metastatic dissemination. Although individual metastasis-associated genes have been described, complex regulatory presiding over initiation and maintenance tumors still poorly understood. There is untapped value in identifying therapeutic targets broadly govern coordinated modules dictating progression. Here, we reverse engineered interrogated a breast cancer-specific interaction network...
Ampullary cancers refer to tumors originating from the ampulla of Vater (the ampulla, intraduodenal portion bile duct, and pancreatic duct), while periampullary may arise locations encompassing head pancreas, distal duodenum, or Vater. are rare gastrointestinal malignancies, prognosis varies greatly based on factors such as patient age, TNM classification, differentiation grade, treatment modality received. Systemic therapy is used in all stages ampullary cancer, including neoadjuvant...
The PhoP-PhoQ two-component system is a well studied bacterial signaling that regulates virulence and stress response. Catalytic activity of the histidine kinase sensor protein PhoQ activated by low extracellular concentrations divalent cations such as Mg2+, subsequently response regulator PhoP in turn through classic phosphotransfer pathway typical systems. domains enteric bacteria contain an acidic cluster residues (EDDDDAE) has been implicated direct binding to cations. We have determined...
Glioblastoma (GBM) is a highly aggressive type of glioma with poor prognosis. However, small number patients live much longer than the median survival. A better understanding these long-term survivors (LTSs) may provide important insight into biology GBM. We identified 7 GBM, treated at Memorial Sloan-Kettering Cancer Center (MSKCC), survival >48 months. characterized transcriptome each patient and determined rates MGMT promoter methylation IDH1 IDH2 mutational status. LTSs in 2 independent...
Patients treated for a thoracic malignancy carry significant risk of developing other lung lesions. Locoregional control intrathoracic recurrences is challenging due to the impact prior therapies on normal tissues. We examined safety and efficacy re-irradiation using high-precision image-guided stereotactic body radiation therapy (SBRT).Records 39 patients with intra-thoracic conventionally fractionated (RT) who underwent SBRT subsequent primary, recurrent or metastatic tumor from 11/2004...
Stereotactic body radiation therapy delivered using MR-guided radiotherapy (MRgRT) and automatic breathold gating has shown to improve overall survival for locally advanced pancreatic cancer (LAPC) patients. The goal of our study was evaluate feasibility treating LAPC patients abdominal compression (AC) impact potential intrafraction motion on planned dose a 1.5T MR-linac.
Recent evidence suggests a rising incidence of cancer in younger individuals. Herein, we report the epidemiologic, pathologic, and molecular characteristics patient cohort with early-onset pancreas (EOPC).
The BRCA1 tumor suppressor has been implicated in the maintenance of chromosomal stability through homology-directed repair DNA double-strand breaks. Much cells forms a heterodimeric complex with structurally related protein BARD1. We report that expression truncated mouse or human BARD1 peptides capable interacting Brca1 results homologous-repair deficiency. Repair is mildly reduced wild-type and severely harbor splice product deleted for exon 11. Nuclear localization not compromised,...
The value of neoadjuvant radiotherapy (RT) after 5-fluorouracil with leucovorin, oxaliplatin, and irinotecan, or without dose modifications [(m)FOLFIRINOX], for patients borderline resectable (BR) pancreatic ductal adenocarcinoma (PDAC) is uncertain.
Background: Stereotactic body radiation therapy (SBRT) is an emerging treatment option for unresectable pancreatic cancer, and postulated to be more effective less toxic than conventionally fractionated intensity modulated (IMRT).Material methods: We retrospectively reviewed stage I–III adenocarcinoma treated from 2008 2016 at our institution with SBRT (five fractions, 30–33 Gy) or IMRT (25–28 45–56 Gy concurrent chemotherapy). Groups were compared respect overall survival (OS), local...
Background and Objectives Achieving a pathologic complete response (pCR) after neoadjuvant therapy has been associated with better prognosis in rectal cancer patients. The objective of this study was to investigate the relationship between distance anal verge (DTAV) pCR. Methods Review prospectively maintained database patients locally advanced who received treatment completed. Uni- multivariate analysis assessed association DTAV pCR therapy. Results Of 827 included patients, 20% had We...