A5010136395- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Anorectal Disease Treatments and Outcomes
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Diverticular Disease and Complications
- Pancreatic and Hepatic Oncology Research
- Pelvic floor disorders treatments
- Cancer Cells and Metastasis
- Gastrointestinal Tumor Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Surgical site infection prevention
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Surgical Simulation and Training
- Ovarian cancer diagnosis and treatment
- Intraperitoneal and Appendiceal Malignancies
- Clinical practice guidelines implementation
- Multiple and Secondary Primary Cancers
Memorial Sloan Kettering Cancer Center
2016-2025
Cancer Research Center
2022-2024
Kettering University
2015-2024
Universidade de São Paulo
2024
Hospital Universitario De Cabueñes
2024
Twitter (United States)
2024
Cornell University
2017-2024
Intuitive Surgical (Switzerland)
2024
Comillas Pontifical University
2024
Hospital Clínico San Carlos
1997-2024
Neoadjuvant chemotherapy and radiation followed by surgical resection of the rectum is a standard treatment for locally advanced rectal cancer. A subset cancer caused deficiency in mismatch repair. Because repair-deficient colorectal responsive to programmed death 1 (PD-1) blockade context metastatic disease, it was hypothesized that checkpoint could be effective patients with repair-deficient,
While the leukocyte integrin lymphocyte function-associated antigen (LFA)-1 has been demonstrated to bind intercellular adhesion molecule (ICAM)-1, results with related Mac-1 have controversial. We used multiple cell binding assays, purified and ICAM-1, lines transfected ICAM-1 cDNAs examine interaction of Mac-1. Stimulated human umbilical vein endothelial cells (HUVECs), which express a high surface density immunoaffinity-purified adsorbed artificial substrates in manner that is inhibited...
PURPOSE Prospective data on the efficacy of a watch-and-wait strategy to achieve organ preservation in patients with locally advanced rectal cancer treated total neoadjuvant therapy are limited. METHODS In this prospective, randomized phase II trial, we assessed outcomes 324 stage or III adenocarcinoma induction chemotherapy followed by chemoradiotherapy (INCT-CRT) consolidation (CRT-CNCT) and either mesorectal excision (TME) basis tumor response. Patients both groups received 4 months...
Despite the identification and characterization of several distinct ligands for leukocyte integrin (CD11/CD18) family adhesion receptors, little is known about structural regions on these molecules that mediate ligand recognition. In this report, we use alpha subunit chimeras Mac-1 (CD11b/CD18) p150,95 (CD11c/CD18), an extended panel newly generated previously characterized mAbs specific to chain map binding sites four Mac-1: iC3b, fibrinogen, ICAM-1, as-yet uncharacterized counter-receptor...
<h3>Importance</h3> Treatment of locally advanced rectal (LARC) cancer involves chemoradiation, surgery, and chemotherapy. The concept total neoadjuvant therapy (TNT), in which chemoradiation chemotherapy are administered prior to has been developed optimize delivery effective systemic aimed at micrometastases. <h3>Objective</h3> To compare the traditional approach preoperative (chemoRT) followed by postoperative adjuvant with more recent TNT for LARC. <h3>Design, Setting, Participants</h3>...
This study was undertaken to assess results of surgery for fistula-in-ano and identify risk factors fistula recurrence impaired continence.We reviewed the records 624 patients who underwent between 1988 1992. Follow-up by mailed questionnaire, with 375 (60 percent) responding. Mean follow-up 29 months. Fistulas were intersphincteric in 180 patients, transsphincteric 108, suprasphincteric 6, extrasphincteric unclassified 75. Procedures included fistulotomy marsupialization (n = 300), seton...
The watch-and-wait (WW) strategy aims to spare patients with rectal cancer unnecessary resection.To analyze the outcomes of WW among who had a clinical complete response neoadjuvant therapy.This retrospective case series analysis conducted at comprehensive center in New York included received diagnosis adenocarcinoma between January 1, 2006, and 31, 2015. median follow-up was 43 months. Data analyses were from June 2016, October 2018.Patients after completing therapy agreed active...
Radical surgery of rectal cancer is associated with significant morbidity, and some patients low-lying lesions must accept a permanent colostomy. Several studies have suggested satisfactory tumor control after local excision early cancer. The purpose this study was to compare recurrence survival rates treating cancers radical surgery.One hundred eight T1 T2 adenocarcinomas treated by transanal were compared 153 T1N0 T2N0 surgery. Neither group received adjuvant chemoradiation. Mean follow-up...
<h3>Importance</h3> Guidelines for cancer genetic testing based on family history may miss clinically actionable changes with established implications screening or prevention. <h3>Objective</h3> To determine the proportion and potential clinical of inherited variants detected using simultaneous sequencing tumor normal tissue ("tumor-normal sequencing") compared test results current guidelines. <h3>Design, Setting, Participants</h3> From January 2014 until May 2016 at Memorial Sloan Kettering...
Improvements in magnetic resonance imaging (MRI), total mesorectal excision (TME) surgery, and the use of (chemo)radiotherapy ([C]RT) have improved local control rectal cancer; however, we been unable to eradicate recurrence (LR). Even face TME negative resection margins (R0), a significant proportion patients with enlarged lateral lymph nodes (LLNs) suffer from LR (LLR). Japanese studies suggest that addition an LLN dissection (LLND) could reduce LLR. This multicenter pooled analysis aims...
Preoperative chemoradiation reduces tumor size and nodal metastasis in patients with rectal cancer. Tumor downstaging has been associated an increased probability of a sphincter-saving procedure improved local control. However, pathologic complete response to not correlated control patient survival. We studied the prognostic value preoperative cancer patients.We have prospectively followed up 168 consecutive ultrasound Stages II (46) III (122) treated by radical resection mesorectal...
Treatment of patients with non-metastatic, locally advanced rectal cancer (LARC) includes pre-operative chemoradiation, total mesorectal excision (TME) and post-operative adjuvant chemotherapy. This trimodality treatment provides local tumor control in most patients; but almost one-third ultimately die from distant metastasis. Most survivors experience significant impairment quality life (QoL), due primarily to removal the rectum. A current challenge lies identifying who could safely undergo...
Purpose To investigate the value of T2-weighted-based radiomics compared with qualitative assessment at T2-weighted imaging and diffusion-weighted (DW) for diagnosis clinical complete response in patients rectal cancer after neoadjuvant chemotherapy-radiation therapy (CRT). Materials Methods This retrospective study included 114 who underwent magnetic resonance (MR) CRT between March 2012 February 2016. Median age among women (47 114, 41%) was 55.9 years (interquartile range, 45.4-66.7...
Objective: To determine whether extending the interval between chemoradiation (CRT) and surgery, administering additional chemotherapy during waiting period has an impact on tumor response, CRT-related toxicity surgical complications in patients with advanced rectal cancer. Background: Locally cancer is usually treated preoperative CRT followed by surgery approximately 6 weeks later. The Timing of Rectal Cancer Response to Chemoradiation Consortium designed a prospective, multicenter, Phase...
OverviewVenous thromboembolism (VTE) is a common and life-threatening condition in patients with cancer. 1,2esults from retrospective study of 66,106 hospitalized adult neutropenic cancer showed that 2.7% to 12.1% these patients, depending on the type malignancy, experienced VTE during their first hospitalization. 1These NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) specifically outline strategies prevent treat either diagnosed or for whom clinically suspected.
Tumor regression grade (TRG) is a measure of histopathological response rectal cancer to neoadjuvant chemoradiation and associated with outcomes. Several TRG systems are used: Mandard (5,3-tier), Dowrak/Rödel Memorial Sloan Kettering Cancer Center (MSKCC), American Joint Committee on (AJCC) Staging. A single would assist in comparing results across institutions, designing future studies. In this study, the predictive accuracies various published classification schemes compared.Review...