A5060683041- Advanced Breast Cancer Therapies
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- PARP inhibition in cancer therapy
- T-cell and B-cell Immunology
- Viral-associated cancers and disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Vascular Tumors and Angiosarcomas
- Immune Cell Function and Interaction
Memorial Sloan Kettering Cancer Center
2017-2025
Cornell University
2018
Copenhagen Municipal Hospital
1976
<h3>Importance</h3> Treatment of locally advanced rectal (LARC) cancer involves chemoradiation, surgery, and chemotherapy. The concept total neoadjuvant therapy (TNT), in which chemoradiation chemotherapy are administered prior to has been developed optimize delivery effective systemic aimed at micrometastases. <h3>Objective</h3> To compare the traditional approach preoperative (chemoRT) followed by postoperative adjuvant with more recent TNT for LARC. <h3>Design, Setting, Participants</h3>...
Purpose Alterations in DNA damage response and repair (DDR) genes are associated with increased mutation load improved clinical outcomes platinum-treated metastatic urothelial carcinoma. We examined the relationship between DDR alterations to PD-1/PD-L1 blockade. Methods Detailed demographic, treatment response, long-term outcome data were collected on patients carcinoma treated atezolizumab or nivolumab who had targeted exon sequencing performed pre-immunotherapy tumor specimens. Presence...
Objective: In 2015, the American Gastroenterological Association recommended discontinuation of radiographic surveillance after 5 years for patients with stable pancreatic cysts. The current study evaluated yield continued cysts up to and follow up. Methods: A prospectively maintained registry was queried (1995–2016). Patients who initially underwent were divided into those <5 ≥5 Analyses presence cyst growth (>5 mm increase in diameter), cross-over resection, development carcinoma...
Lymph node metastasis (LNM) drastically reduces survival after resection of intrahepatic cholangiocarcinoma (IHC). Optimal treatment is ill defined, and it unclear whether tumor mutational profiling can support decisions.Patients with liver-limited IHC or without LNM treated (N = 237), hepatic arterial infusion chemotherapy (HAIC; N 196), systemic alone (SYS; 140) at our institution between 2000 2018 were included. Genomic sequencing was analyzed to determine genetic alterations could...
Guidelines recommend vaccination starting 12 months after autologous hematopoietic stem cell transplant (aHCT), but there is varying practice for patients on maintenance therapy, with some centers not immunizing at all. Because of decreased vaccine rates among the general population causing loss herd immunity, we aimed to establish safety and efficacy revaccinating multiple myeloma lenalidomide (LM). Of 122 who were vaccinated aHCT between 2010 2014 Memorial Sloan Kettering Cancer Center, 91...
Abstract Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing regions rising burden disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate microsatellite instability significantly higher among CRC (28.1%) than Cancer Genome Atlas (TCGA, 14.2%) Memorial Sloan Kettering Center (MSKCC, 8.5%, P < 0.001). In microsatellite-stable cases, tumors are less likely have...
Abstract Purpose: We conducted research on CDK4/6 inhibitors (CDK4/6i) simultaneously in the preclinical and clinical spaces to gain a deeper understanding of how senescence influences tumor growth humans. Patients Methods: coordinated first-in-kind phase II trial CDK4/6i abemaciclib for patients with progressive dedifferentiated liposarcoma (DDLS) cellular studies interrogating molecular basis geroconversion. Results: Thirty progressing DDLS enrolled were treated 200 mg twice daily. The...
Objective: To evaluate whether patient-controlled epidural analgesia (PCEA) improves postoperative pain during ambulation following elective open hepatectomy. Background: Strategies to alleviate are a critical element of recovery after surgery. However, the optimal management strategy hepatectomy remains unclear. Methods: We conducted prospective, non-blinded, randomized comparison PCEA (intervention) vs. intravenous (IV PCA; control) for The primary endpoint was on day (POD) 2. study...
640 Background: Pancreatic ductal adenocarcinoma (PDAC) remains a challenging disease due to its aggressive nature, late-stage diagnosis, and limited treatment options. There is an increased interest in cancers which harbor microsatellite instability (MSI) their susceptibility immune checkpoint inhibitors. MSI PDAC rare, little known about survival this subtype of pancreas cancers. Our aim was assess overall surgically resected high (MSI-H), mismatch repair deficient (MMRd), Lynch Syndrome...
Abstract Purpose: Survival of patients with metastatic sarcoma remains poor, and there is a pressing need for new therapies. Most subtypes are not responsive to immune checkpoint inhibition alone. Lenvatinib, multireceptor tyrosine kinase inhibitor targeting tumor vasculature, has an immunomodulatory activity that contributes its antitumor effects. Therefore, we hypothesized combination lenvatinib pembrolizumab would lead improved clinical outcomes in sarcoma. Patients Methods: This was...
PURPOSE Clinical trials are integral for patients with cancer but remain inaccessible to many because of barriers including geographic and transportation challenges. This study aimed evaluate patients' preferences telemedicine versus in-person visits clinical trial discussions informed consent (IC). METHODS An electronic survey was administered first-time users at Memorial Sloan Kettering Cancer Center from 2021 2023. The assessed the IC process their comfort discussing virtually. primary...
11552 Background: Liposarcomas (LPS) are among the most common soft tissue sarcoma subtypes. Well-differentiated (WD) and dedifferentiated (DD) LPS characterized by CDK4 MDM2 amplification. Both subtypes have variable sensitivity to chemotherapy. However, effective systemic treatment options remain limited for unresectable or metastatic disease. Our group previously reported two phase 2 trials of CDK4/6 inhibitor (CDK4/6i) palbociclib (PD0332991) in advanced WD/DD LPS, which established...
Colorectal cancer (CRC) is the third most common worldwide. Mortality for CRC improving in high income countries, but low and middle rates of disease death from are rising. In Sub-Saharan Africa, ratio mortality to incidence highest world. This study investigated nature treatment currently being offered received Nigeria.Between April 2013 October 2017, a prospective consecutively diagnosed cases was conducted. Patient demographics, clinical features, recommended recorded each case. Patients...
The clinical behavior of ampullary adenocarcinoma varies widely. Targeted tumor sequencing may better define biologically distinct subtypes to improve diagnosis and management.The hidden-genome algorithm, a multilevel meta-feature regression model, was trained on prospectively sequenced cohort 3,411 patients (1,001 pancreatic adenocarcinoma, 165 distal bile-duct 2,245 colorectal adenocarcinoma) subsequently applied targeted panel DNA-sequencing data from adenocarcinomas. Genomic...
PURPOSE: Although delirium is known to negatively affect critically ill patients, little data exist on in patients with cancer. METHODS: We analyzed 915 cancer between January and December 2018. Delirium screening was performed using the Confusion Assessment Method for intensive care unit (ICU), twice daily. Method-ICU incorporates four features of delirium: acute fluctuations mental status, inattention, disorganized thinking, altered levels consciousness. Multivariable analysis controlling...
Abstract The association between immune-related AEs (irAE) and outcome in patients with sarcoma is not known. We retrospectively reviewed a cohort of advanced treated immune checkpoint blockade (ICB)-based therapy. Association irAEs survival was assessed using Cox regression model that incorporated irAE occurrence as time-dependent covariate. Tumor samples available RNA sequencing data were stratified by presence an to identify patterns differential gene expression. A total 131 included....
Abstract Purpose: To determine if a targeted exome panel utilizing matched normal DNA can accurately detect germline and somatic HLA genes in patients with synovial sarcoma (SS) whether select HLA-A*02 genotypes are prognostic or predictive of outcome metastatic SS. Experimental Design: Patients SS consented to typing by Clinical Laboratory Improvement Amendments (CLIA)-certified test eligibility for clinical trial NY-ESO-1–specific engineered T cells restricted carriers HLA-A*02:01,...
Colorectal cancer (CRC) rates in low-resource countries, which typically lack CRC screening programs, are rising. This study determined whether a risk model for patients with rectal bleeding could identify curable CRC.This prospective, cross-sectional evaluated constructed from data 1 hospital and validated at 2 other hospitals. The primary endpoint was the ability of to predict CRC, as diagnosed by colonoscopy, clinical characteristics. secondary determine percentage who had CRC.Consecutive...
Abstract Background After resection of colorectal liver metastases (CRLM), recurrent disease in the is a major cause death but may be reduced with addition adjuvant hepatic arterial infusion (HAI) chemotherapy to systemic (SYS). Objective This study investigates organ‐specific causes patients receiving HAI and SYS compared alone. Methods Between 2000 2007, undergoing complete CRLM were identified from prospectively maintained database categorized as + or only. Using newly constructed...