A5060048130- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Diet and metabolism studies
- Colorectal Cancer Treatments and Studies
- Diabetes Management and Research
- CAR-T cell therapy research
- Health Systems, Economic Evaluations, Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Parkinson's Disease Mechanisms and Treatments
- Organ Donation and Transplantation
- Cancer Risks and Factors
- HIV-related health complications and treatments
- Cardiac tumors and thrombi
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Cancer Immunotherapy and Biomarkers
- Autism Spectrum Disorder Research
- Management of metastatic bone disease
- Healthcare Systems and Reforms
- Global Public Health Policies and Epidemiology
- Systemic Lupus Erythematosus Research
- Cutaneous lymphoproliferative disorders research
Memorial Sloan Kettering Cancer Center
2019-2023
California State University, Fresno
2021
University of California, San Francisco
2021
Collaborative Group (United States)
2021
Kettering University
2020
For patients with sentinel lymph node (SLN)-positive cutaneous melanoma, the Second Multicenter Selective Lymphadenectomy trial demonstrated equivalent disease-specific survival (DSS) active surveillance using nodal ultrasound versus completion dissection (CLND). Adoption and outcomes of in clinical practice adjuvant therapy recipients are unknown.In a retrospective cohort SLN-positive adults treated at 21 institutions Australia, Europe, United States from June 2017 to November 2019, authors...
Abstract Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing regions rising burden disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate microsatellite instability significantly higher among CRC (28.1%) than Cancer Genome Atlas (TCGA, 14.2%) Memorial Sloan Kettering Center (MSKCC, 8.5%, P < 0.001). In microsatellite-stable cases, tumors are less likely have...
Background/aims Cancer burden is predicted to double by 2030 in sub-Saharan Africa; access healthcare services for cancer management a priority the region. In Nigeria, National Control Plan aims ensure >50% screening of eligible populations 2022 all Nigerians. We describe utilisation, activities and potential barriers accessing care within an understudied rural community-based adult population South West Nigeria. Methods April 2018, we conducted cross-sectional study adults (>18 years)...
Objective: The aim of this study was to determine overall trends and center-level variation in utilization completion lymph node dissection (CLND) adjuvant systemic therapy for sentinel (SLN)-positive melanoma. Summary Background Data: Based on recent clinical trials, management options SLN-positive melanoma now include effective nodal observation instead CLND. It is unknown how these findings have shaped practice or contemporaneous developments influenced their respective utilization....
Colorectal cancer (CRC) is the third most common worldwide. Mortality for CRC improving in high income countries, but low and middle rates of disease death from are rising. In Sub-Saharan Africa, ratio mortality to incidence highest world. This study investigated nature treatment currently being offered received Nigeria.Between April 2013 October 2017, a prospective consecutively diagnosed cases was conducted. Patient demographics, clinical features, recommended recorded each case. Patients...
In sentinel lymph node (SLN)-positive melanoma, two randomized trials demonstrated equivalent melanoma-specific survival with nodal surveillance vs completion dissection (CLND). Patients microsatellites, extranodal extension (ENE) in the SLN, or >3 positive SLNs constitute a high-risk group largely excluded from trials, for whom appropriate management remains unknown.
Until recently, most patients with sentinel lymph node-positive (SLN+) melanoma underwent a completion node dissection (CLND), as mandated in published trials of adjuvant systemic therapies. Following multicenter selective lymphadenectomy trial-II, SLN+ no longer undergo CLND prior to therapy. A retrospective analysis clinical outcomes treated therapy after July 2017 was performed 21 international cancer centers. Of 462 who received therapy, 326 anti-PD-1 without immediate (IM) CLND, while...
PURPOSE Radiation-associated sarcomas (RAS) are rare but aggressive malignancies. We sought to characterize the histology-specific presentation and behavior of soft tissue RAS improve individualized prognostication. METHODS A single-institutional prospectively maintained database was queried for all patients with primary, nonmetastatic treated surgical resection from 1982 2019. Patients presenting five most common histologies were propensity-matched those sporadic tumors same histology....
e12585 Background: Breast cancer incidence and mortality is increasing in LMICs especially sub-Saharan Africa, attributed to changes lifestyle possible biological differences. To study putative relationships among factors, tumor biology, the microenvironment, we aimed develop a breast tissue biobank linked with clinicopathologic patient reported data this resource constrained setting. Methods: We prospectively enrolled patients undergoing mastectomy at Obafemi Awolowo University Teaching...
Successful percutaneous mechanical circulatory support (MCS) has been used for acute stabilization of cardiogenic shock (CS). Improved survival outcomes have observed in patients with CS from an myocardial infarction (AMI) who undergo implantation left ventricular (LV) to ascending aorta rotodynamic pumps, such as the Impella® device (Abiomed). However, thrombotic events are a known complication devices poor flow states CS. There is limited evidence regarding management develop LV thrombus...
The burden of colorectal cancer (CRC) is increasing in West Africa. Understanding the molecular and clinicopathologic profile region’s CRC patients vital to optimizing early detection therapeutic regimens. Clinicopathologic data from consecutive a multicenter, prospectively maintained Nigerian database were compared contemporary cohort Memorial Sloan Kettering Cancer Center (MSKCC). Fresh-frozen tissue was analyzed with multigene, next-generation sequencing assay, along immunohistochemistry...
e12560 Background: Racial disparities in breast cancer outcomes pose a major public health challenge. Complex interactions between social determinants of and tumor biology, mediated by obesity adiposity, may play an important role these disparities. White adipose tissue inflammation (WATi) the breast, which is histologically defined presence crown-like structures (CLS-B), occurs setting excess adiposity promotes growth via elevated levels aromatase, proinflammatory factors, metabolic...
HIV infection is known to predispose venous thromboembolism (VTE), the risk ranging from 2% 10% in adults [1]. A thrombotic state occurs because of abnormalities coagulation system and platelet activation, endothelial dysfunction, opportunistic infections antiretroviral therapy (ART) [2]. However, there are only a few reports thrombosis HIV-infected children [3–5] and, best our knowledge, portal vein has never been reported [6–8]. We report two who developed this very uncommon complication....
Sharma, Avinash; Chopra, Rajus; Alnababteh, Muhtadi; Huang, Sean; Yohannes, Seife Author Information