A5061389009- Reconstructive Surgery and Microvascular Techniques
- Mesenchymal stem cell research
- Breast Implant and Reconstruction
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Pancreatic function and diabetes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Cells and Metastasis
- Body Contouring and Surgery
- Endoplasmic Reticulum Stress and Disease
- Fibroblast Growth Factor Research
- Liver Disease Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Alcohol Consumption and Health Effects
- Immune responses and vaccinations
- Kruppel-like factors research
- Diet and metabolism studies
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Breast Cancer Treatment Studies
Yeungnam University College
2022-2024
Kyungpook National University
2016-2024
Yeungnam University
2022-2024
Institute of Aging
2023
Kyungpook National University Hospital
2015
Abstract Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Here we show regulates white and brown adipose tissue function. Pharmacological inhibition of synthesis leads to lipogenesis epididymal (WAT), induction browning inguinal WAT activation adaptive thermogenesis (BAT). Mice with inducible Tph1 KO tissues exhibit a similar phenotype as mice which inhibited...
Ca2+ overload-induced mitochondrial dysfunction is considered as a major contributing factor in the pathogenesis of alcohol-associated liver disease (ALD). However, initiating factors that drive accumulation ALD remain elusive. Here, we demonstrate an aberrant increase hepatic GRP75-mediated mitochondria-associated ER membrane (MAM) Ca2+-channeling (MCC) complex formation promotes vitro and male mouse model ALD. Unbiased transcriptomic analysis reveals PDK4 prominently inducible MAM kinase...
Hepatic steatosis is associated with increased insulin resistance and tricarboxylic acid (TCA) cycle flux, but decreased ketogenesis pyruvate dehydrogenase complex (PDC) flux. This study examined whether hepatic PDC activation by inhibition of kinase 2 (PDK2) ameliorates these metabolic abnormalities. Wild-type mice fed a high-fat diet exhibited steatosis, resistance, levels pyruvate, TCA intermediates, malonyl-CoA reduced activity due to PDK2 induction. attenuated improved sensitivity,...
Neutrophils are primed for neutrophil extracellular trap (NET) formation during diabetes, and excessive NET from neutrophils compromises wound healing in patients with diabetes. Here, we demonstrate that trained immunity mediates diabetes-induced priming neutrophils. Under diabetic conditions, exhibit robust metabolic reprogramming comprising enhanced glycolysis via the pentose phosphate pathway fatty acid oxidation, which result accumulation of acetyl-coenzyme A. Adenosine...
Dyslipidemia-induced atherosclerosis, which has a risk of high morbidity and mortality, can be alleviated by metabolic activation associated with mitochondrial function. The effect dichloroacetate (DCA), general pyruvate dehydrogenase kinase (PDK) inhibitor, on in vivo energy expenditure ApoE-/- mice fed western diet (WD) not yet been investigated. WD-fed developed atherosclerotic plaques hyperlipidemia along obesity, were significantly ameliorated DCA administration. Increased oxygen...
Acellular dermal matrix (ADM) in implant-based breast reconstruction can show various ultrasound (US) findings. However, there are limited reports on the US features of ADM. The aims this study were to evaluate findings ADM and correlate them with histopathological findings.Between January 2015 August 2020, 250 women who underwent a examination at 6 months 1 year after retrospectively analyzed. Abnormal classified as type (focal thickening decreased echogenicity), 2 (diffusely hyperechoic),...
Abstract Background Adipose-derived stem cells (ASCs) have been reported to reduce fibrosis in various tissues. In this study, we investigated the inhibitory role of ASCs on capsule formation by analyzing histologic, cellular, and molecular changes a mouse model peri-implant fibrosis. We also fate distribution capsule. Methods To establish model, customized silicone implants were inserted into dorsal site C57BL/6 wild-type mice. harvested from fat tissues transgenic mice that express green...
CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode action remains to be elucidated. KK-Ay mice, type 2 diabetes mellitus (T2DM) model, were administered CycloZ either as preventive intervention, or therapy. Glycemic control was evaluated using the oral glucose tolerance test (OGTT), glycosylated hemoglobin (HbA1c) levels. Liver visceral adipose tissues (VATs) used for histological evaluation, gene expression analysis, protein analysis....
Acellular dermal matrix (ADM) is composed of extracellular (ECM) and widely used in implant-based breast reconstructions. However, long-term changes the ADM around implants have not been established. This study aimed to investigate covering using serial ultrasound histologic evaluations.The authors evaluated results 145 patients who underwent reconstructions with coverings. The obtained within 18 months surgery those 5 years postoperatively were analyzed determine change thickness. For...
Abstract Autologous fat grafting is among the safest and most effective treatments for soft-tissue restoration augmentation, many efforts have been made to improve its efficiency, including adipose-derived stem cell (ASC) supplementation. Here, we investigated role of Notch ligand Delta-like 4 (Dll4) in angiogenesis within grafted effect on graft retention, as well Dll4 inhibition ASC Using a murine model, expression grafts assessed volume, vascularity, perfusion graft, differentiation...
Background: Although implant-based breast reconstruction is a common surgical modality, periprosthetic capsule inevitably forms and worsens in cases of postmastectomy radiation therapy. Previous animal studies have reported that anti-adhesive agents (AAAs) inhibit formation. We prospectively examined the clinical effects an AAA (Mediclore ® ) on formation reconstruction. Methods: analyzed patients who underwent immediate two-stage following total mastectomy for malignancy between November...