A5035611562- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Parkinson's Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neural Engineering
- Receptor Mechanisms and Signaling
- Neuroscience and Music Perception
- Circadian rhythm and melatonin
- Optical Imaging and Spectroscopy Techniques
- Regulation of Appetite and Obesity
- Neural and Behavioral Psychology Studies
- Sleep and Wakefulness Research
- Neurobiology and Insect Physiology Research
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroendocrine regulation and behavior
- Infectious Encephalopathies and Encephalitis
- Behavioral and Psychological Studies
- Sleep and related disorders
- Motor Control and Adaptation
Center for Neurosciences
2024
Duke University
2017-2023
SK Life Science (United States)
2023
LivaNova (United States)
2021-2022
Pennsylvania State University
2013-2020
Zero to Three
2016
Millennium Engineering and Integration (United States)
2016
University of Delaware
2012
Duke Medical Center
1998
Community Health Center
1998
The claustrum (CLA) is a subcortical structure, present only in mammals, whose function remains uncertain. Previously, using resting-state functional magnetic resonance imaging (rs-fMRI) awake head-fixed rats, we found evidence that the CLA part of rodent homolog default mode network (DMN; Smith et al., 2017). This emerged as strong connections between medial prefrontal cortex (mPFC), mediodorsal (MD) thalamus, and state, which was not following administration isoflurane anesthesia. In...
The dorsal striatum has two functionally-defined subdivisions: a dorsomedial (DMS) region involved in mediating goal-directed behaviors that require conscious effort, and dorsolateral (DLS) the execution of habitual familiar sensory context. Consistent with its presumed role forming stimulus-response (S-R) associations, neurons DLS receive massive inputs from sensorimotor cortex are responsive to both active passive stimulation. While several studies have established corticostriatal...
Selective activation of Pf-STN pathway initiates actions in normal mice and restores movement a mouse model PD.
There is uncertainty concerning the circuit connections by which superior colliculus interacts with basal ganglia. To address this issue, anterograde and retrograde tracers were placed, respectively, into globus pallidus of Sprague-Dawley rats. In two-tracer experiment, projections from terminated densely in ventral zona incerta (ZIv), but did not overlap labeled neurons observed subthalamic nucleus. cases sensory-responsive sites posteromedial (POm) thalamus, innervated ZIv regions that...
We have previously shown that the claustrum is part of an interhemispheric circuit interconnects somesthetic-motor and visual-motor cortical regions. The role in processing limbic information, however, poorly understood. Some evidence suggests dorsal endopiriform nucleus (DEn), which lies immediately ventral to claustrum, has connections with areas should be considered a claustrum-DEn complex. To determine whether DEn similar patterns as we used anterograde retrograde tracing techniques...
Abstract Most adaptive behaviors require precise tracking of targets in space. In pursuit behavior with a moving target, mice use distance to target guide their own movement continuously. Here, we show that the sensorimotor striatum, parvalbumin-positive fast-spiking interneurons (FSIs) can represent between self and during behavior, while striatal projection neurons (SPNs), which receive FSI projections, self-velocity. FSIs are shown regulate velocity-related SPN activity pursuit, so...
Animals can learn to repeat behaviors earn desired rewards, a process commonly known as reinforcement learning. While previous work has implicated the ascending dopaminergic projections basal ganglia in learning, little is about role of hippocampus. Here, we report that specific population hippocampal neurons and their innervation contribute operant self-stimulation. These are located dentate gyrus, receive from locus coeruleus, express D1 dopamine receptors. Activation + sufficient for...
The dorsolateral striatum (DLS) is critical for executing sensorimotor behaviors that depend on stimulus-response (S-R) associations. In rats, the DLS receives it densest inputs from primary somatosensory (SI) cortex, but also substantial input thalamus. Much of rat devoted to processing whisker-related information, and thalamic projections these whisker-responsive regions originate parafascicular (Pf) medial posterior (POm) nuclei. To determine which nucleus better suited mediating S-R...
The primary (S1) and secondary (S2) somatosensory cortices project to several trigeminal sensory nuclei. One putative function of these corticofugal projections is the gating transmission through principal nucleus (Pr5), some have proposed that S1 S2 differentially spinal subnuclei, which inhibitory circuits could inhibit or disinhibit output Pr5. Very little, however, known about origin sensorimotor their patterns termination in various We addressed this issue by injecting anterograde...
The basal ganglia have been implicated in action selection and timing, but the relative contributions of striatonigral (direct) striatopallidal (indirect) pathways to these functions remain unclear. We investigated effects optogenetic stimulation D1+ A2A+ neurons ventrolateral striatum head-fixed mice on a fixed time reinforcement schedule. Direct pathway initiates licking, whereas indirect suppresses licking results rebound after stimulation. Moreover, direct also play distinct roles...
<i>Background:</i> We describe the implementation and subsequent use of a computerized health maintenance tracking system in large, urban, North Carolina community center (Lincoln Community Health Center) as part larger study designed to increase rates mammography, Papanicolaou tests, smoking cessation low-income African-Americans. <i>Methods:</i> Clinicians from Lincoln Center were involved design computer system. At each office visit, clinicians received encounter form indicating needed...
Abstract The Ventral Tegmental Area (VTA) is a major source of dopamine, especially to the limbic brain regions. Despite decades research, function VTA dopamine neurons remains controversial. Here, using novel head-fixed behavioral system with five orthogonal force sensors, we show for first time that distinct populations activity precisely represent impulse vector (force exerted over time) generated by animal. Optogenetic excitation quantitatively determines in forward direction, and...
Choice behavior is characterized by temporal discounting, i.e., preference for immediate rewards given a choice between and delayed rewards. Agouti-related peptide (AgRP)-expressing neurons located in the arcuate nucleus of hypothalamus (ARC) regulate food intake energy homeostasis, yet whether AgRP influence discounting unknown. Here, we demonstrate that motivational state potently modulates discounting. Hungry mice (both male female) strongly preferred rewards, sated were largely...
Patients often recognize unmet needs that can improve patient–provider experiences in disease treatment management. These are rarely captured and may be hard to quantify difficult-to-treat states such as drug-resistant epilepsy (DRE). To further understand challenges living with managing DRE, a team of medical anthropologists conducted ethnographic field assessments patients qualitatively their experience DRE across the United States. In addition, healthcare provider were community clinics...
Abstract Most adaptive behaviors require precise tracking of targets in space. In pursuit behavior with a moving target, mice use distance to target guide their own movement continuously. Here we show that the sensorimotor striatum, parvalbumin-positive fast-spiking interneurons (FSIs) can represent between self and during behavior, while striatal projection neurons (SPNs), which receive FSI projections, self-velocity. FSIs are shown regulate velocity-related SPN activity pursuit, so...