A5056099833- Pain Mechanisms and Treatments
- Dermatology and Skin Diseases
- Musculoskeletal pain and rehabilitation
- Ion channel regulation and function
- Botulinum Toxin and Related Neurological Disorders
- Neuropeptides and Animal Physiology
- Food Allergy and Anaphylaxis Research
- Circadian rhythm and melatonin
- Acupuncture Treatment Research Studies
- Anesthesia and Pain Management
- Ion Channels and Receptors
- Healthcare and Venom Research
- Neuroscience and Neuropharmacology Research
- Allergic Rhinitis and Sensitization
- Spine and Intervertebral Disc Pathology
- Cardiac Ischemia and Reperfusion
- Pharmacological Effects of Natural Compounds
- Exercise and Physiological Responses
- Stress Responses and Cortisol
- Cholinesterase and Neurodegenerative Diseases
- Pediatric Pain Management Techniques
- Asthma and respiratory diseases
- Mindfulness and Compassion Interventions
- Anesthesia and Neurotoxicity Research
- Pharmacological Receptor Mechanisms and Effects
Sungkyunkwan University
2005-2025
Korea University
2012-2022
Czech Academy of Sciences, Institute of Physiology
2008
The University of Texas Medical Branch at Galveston
1993-1996
This study was conducted to determine the contribution of peripheral inputs from injured and intact afferent fibers behavioral signs neuropathic pain, using a previously developed rat model. Neuropathic injury produced by tightly ligating left L5 L6 spinal nerves; this procedure induced rats display pain behaviors in ipsilateral hindlimb. The included mechanical cold allodynia, as well ongoing pain. Five days after injury, segments (L5 L6) or (L3 L4) were blocked either transection dorsal...
The aim of this study was to determine the effects sympathectomy on our previously developed animal model for neuropathic pain. neuropathy produced by a unilateral tight ligation L5 and L6 spinal nerves in 81 rats, all which showed marked increase frequency paw lifting response innocuous mechanical stimuli shortened latency withdrawal noxious radiant heat affected limb. We interpreted these as behavioral signs allodynia hyperalgesia. Surgical performed removing sympathetic chain bilaterally...
Sensory axons degenerate following separation from their cell body, but partial injury to peripheral nerves may leave the integrity of damaged preserved. We show that an endogenous ligand for natural killer (NK) receptor NKG2D, Retinoic Acid Early 1 (RAE1), is re-expressed in adult dorsal root ganglion neurons nerve injury, triggering selective degeneration injured axons. Infiltration cytotoxic NK cells into sciatic by extravasation occurs within 3 days crush injury. Using a combination...
A series of small compounds acting at the orphan G protein-coupled receptor GPR92 were screened using a signaling pathway-specific reporter assay system. Lipid-derived molecules including farnesyl pyrophosphate (FPP), N-arachidonylglycine (NAG), and lysophosphatidic acid found to activate GPR92. FPP able both G(q/11)- G(s)-mediated pathways, whereas NAG activated only G(q/11)-mediated pathway. Computer-simulated modeling combined with site-directed mutagenesis indicated that Thr(97),...
Transient receptor potential vanilloid subtype 1 (TRPV1) and metabotropic glutamate 5 (mGluR5) located on peripheral sensory terminals have been shown to play critical roles in the transduction modulation of pain sensation. To date, however, very little is known regarding significance functional expression mGluR5 TRPV1 central neurons dorsal horn spinal cord. Here we show that presynaptic coupled a membrane-delimited manner, thereby contributing nociceptive synaptic transmission substantia...
Mechanosensitive channels mediate various physiological functions including somatic sensation or pain. One of the peptide toxins isolated from venom Chilean rose tarantula spider (Grammostola spatulata), mechanotoxin 4 (GsMTx4) is known to block stretch-activated cation channels. Since mechanosensitive in sensory neurons are thought be molecular sensors for mechanotransduction, i.e., touch, pressure, proprioception, and pain, we considered that might some types mechanical In order prepare...
In this work, we propose a novel motor disorder diagnosis model based on graph neural networks (GNNs). This maximizes performance by incorporating advanced preprocessing techniques such as Fast Fourier Transform (FFT) and Wavelet (WT). Conventional machine learning deep models CNN SVM find it difficult to handle nonlinear high-dimensional data in diagnosis. On the other hand, GNN effectively handles these complex structures, enabling more accurate reliable defect classification. Experimental...
PREVIOUS studies showed that heat-hyperalgesia and mechanical allodynia produced by chronic constrictive injury of the sciatic nerve were differentially sensitive to NMDA receptor antagonist dextrorphan morphine other opioid agonists. These results support hypothesis different kinds neuropathic pain symptoms are caused pathological mechanisms. In present study we determined whether thermal unilateral transection ‘superior’ caudal trunk which innervates tail in rats non-competitive MK-801....
Background: N-type Ca 2+ channels (Ca v 2.2) play an important role in the transmission of pain signals to central nervous system. ω-Conotoxin (CTx)-MVIIA, also called ziconotide (Prialt®), effectively alleviates pain, without causing addiction, by blocking pores these channels. Unfortunately, CTx-MVIIA has a narrow therapeutic window and produces serious side effects due poor reversibility its binding channel. It would thus be desirable identify new analgesic blockers with characteristics...
To assess the role of α1G T-type Ca2+ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral susceptibility mice lacking Cav3.1 (α1G-/-), gene encoding pore-forming units these channels. Reduced spontaneous responses and an increased threshold for paw withdrawal response to mechanical stimulation were observed mice. The α1G-/- also showed attenuated thermal hyperalgesia both low-(IR30) high-intensity (IR60) infrared stimulation. Our results reveal importance...
This study investigated whether and how electroacupuncture (EA) attenuates cold hypersensitivity (allodynia) in a rat model of oxaliplatin-induced neuropathic pain. Cold allodynia [evaluated by immersing the tail into water (4 °C) measuring withdrawal latency] was induced 3 days after an oxaliplatin administration (6 mg/kg, i.p.). EA stimulation (2/100 Hz, 0.3-ms pulse duration, 0.2-0.3 mA) delivered to ST36 acupoint or non-acupoint for 20 min. Low-frequency (2 Hz) at relieved more...
Background Discogenic low back pain has been shown to develop into chronic intractable due an unknown pathogenesis. To study the mechanism of discogenic pain, we analyzed serial expression pain-related molecules in dorsal root ganglia (DRG) and thalamus using a newly developed rat model disc degeneration. Methods Ten microliters complete Freund's adjuvant was injected L5-6 male Sprague-Dawley rats for 10 minutes 26-gauge needle. Using behavioral test, with significant were selected...
There is increasing epidemiological evidence of an association between childhood obesity and atopic dermatitis, but little known about the underlying mechanism(s). In present study, we used a rat model dermatitis to assess whether juvenile obesity, induced by reduction litter size, aggravated signs and, if so, this aggravation was associated with changes in plasma concentration adipokines, such as leptin adiponectin. Dermatitis neonatal capsaicin treatment. Body weight, score, serum IgE,...
Atopic dermatitis is a complex disease of heterogeneous pathogenesis, in particular, genetic predisposition, environmental triggers, and their interactions. Indoor air pollution, increasing with urbanization, plays role as risk factor the development AD. However, we still lack detailed picture pollution disease. Here, examined effect formaldehyde (FA) exposure on manifestation atopic underlying molecular mechanism naive rats rat model (AD) produced by neonatal capsaicin treatment. The AD...