A5077805837- CO2 Reduction Techniques and Catalysts
- Pain Mechanisms and Treatments
- Renal Diseases and Glomerulopathies
- Advanced Photocatalysis Techniques
- Renal and related cancers
- CRISPR and Genetic Engineering
- Ionic liquids properties and applications
- Vascular Malformations and Hemangiomas
- Dermatology and Skin Diseases
- Pluripotent Stem Cells Research
- Angiogenesis and VEGF in Cancer
- Electronic and Structural Properties of Oxides
- Landslides and related hazards
- Healthcare and Venom Research
- Allergic Rhinitis and Sensitization
- Geotechnical Engineering and Analysis
- Cancer, Hypoxia, and Metabolism
- Carbon dioxide utilization in catalysis
- Lymphatic System and Diseases
- CAR-T cell therapy research
- Diagnosis and Treatment of Venous Diseases
- Dermatologic Treatments and Research
- Cardiac Fibrosis and Remodeling
- Genetic and Kidney Cyst Diseases
- Tuberous Sclerosis Complex Research
Kunming University of Science and Technology
2022-2025
First People's Hospital of Yunnan Province
2025
Guangzhou Urban Planning Survey & Design Institute
2024
Lunenfeld-Tanenbaum Research Institute
2006-2023
Sinai Health System
2018-2023
Shanghai Institute of Ceramics
2021-2023
Chinese Academy of Sciences
2021-2023
Institute of Psychology, Chinese Academy of Sciences
2023
University of Chinese Academy of Sciences
2023
Xinxiang University
2023
Angiopoietin-1/Tek signaling is a critical regulator of blood vessel development, with conventional knockout angiopoietin-1 or Tek in mice being embryonically lethal due to vascular defects. In addition, thought be required for the stability mature vessels. Using Cre-Lox conditional gene targeting approach, we have studied role embryonic and adult vasculature. We report here that regulating both number diameter developing vessels but not pericyte recruitment. Cardiac-specific reproduced...
Developing industrial-grade electroreduction of CO2 to produce formate (HCOO–)/formic acid (HCOOH) depends on highly active electrocatalysts. However, structural changes due the inevitable self-reduction catalysts result in severe long-term stability issues at current density. Herein, linear cyanamide anion ([NCN]2–)-constructed indium nanoparticles (InNCN) were investigated for reduction HCOO– with a Faradaic efficiency up 96% under partial density (jformate) 250 mA cm–2. Bulk electrolysis...
Using surface-engineered chemical composites to enhance the binding energy of reaction intermediates and conductivity is an attractive route achieve a high partial current density increased yield target products.
Inhibitors of the mammalian target rapamycin (MTOR) belong to a family drugs with potent immunosuppressive, antiangiogenic, and antiproliferative properties. De novo or worsening proteinuria can occur during treatment these agents, but mechanism by which this occurs is unknown. We generated characterized mice carrying podocyte-selective knockout Mtor gene. Although was dispensable in developing podocytes, developed at 3 weeks end stage renal failure 5 after birth. Podocytes from exhibited an...
Significance Reducing vascular leakage and stabilizing the endothelium through activation of angiopoietin (ANGPT)–TIE2 receptor tyrosine kinase pathway is a promising therapeutic strategy for diseases. ANGPT2 one two major ligands TIE2 receptor. Uniquely, possesses an agonistic role in lymphatic endothelium, but acts as competitive antagonist blood endothelium. The molecular basis opposing actions these beds poorly understood. Here we demonstrate that absence VEPTP expression confers agonist...
Abstract The immunogenicity of transplanted allogeneic cells and tissues is a major hurdle to the advancement cell therapies. Here we show that overexpression eight immunomodulatory transgenes ( Pdl1 , Cd200 Cd47 H2-M3 Fasl Serpinb9 Ccl21 Mfge8 ) in mouse embryonic stem (mESCs) sufficient immunologically ‘cloak’ as well derived from them, allowing their survival for months outbred inbred recipients. Overexpression human orthologues these genes ESCs abolished activation peripheral blood...
As an important parameter of forest biomass, height is great significance for the calculation carbon stock and study cycle in large-scale regions. The main idea current inversion methods using multi-baseline P-band polarimetric interferometric synthetic aperture radar (PolInSAR) data to select best baseline inversion. However, approach selecting optimal results process being unable fully utilize abundant observation data. In this paper, solve problem, we propose a method combining analytic...
Podocytes are terminally differentiated cells with an elaborate cytoskeleton and critical components of the glomerular barrier. We identified a bHLH transcription factor, Tcf21, that is highly expressed in developing mature podocytes. Because conventional Tcf21 knockout mice die perinatal period major cardiopulmonary defects, we generated conditional mouse to explore role this factor podocytes vivo. was deleted from podocyte progenitors using podocin-cre (podTcf21) wnt4-cre (wnt4creTcf21)...
Hypertension-associated end-organ damage commonly leads to cardiac and renal fibrosis. As no effective anti-fibrotic therapy currently exists, the unchecked progression of fibrogenesis manifests as cardio-renal failure early death. We have previously shown that FATp300-p300 with intrinsic factor acetyltransferase activity-is an essential epigenetic regulator fibrogenesis, is elevated in several fibrotic tissues. In this report, we investigate therapeutic efficacy a novel FATp300 inhibitor,...
Diabetic nephropathy is a leading cause of end-stage kidney failure. Reduced angiopoietin-TIE2 receptor tyrosine kinase signaling in the vasculature leads to increased vascular permeability, inflammation, and endothelial cell loss associated with development diabetic complications. Here, we identified mechanism explain how TIE2 attenuated animals. Expression protein phosphatase VE-PTP (also known as PTPRB), which dephosphorylates TIE2, robustly up-regulated renal microvasculature rodents,...
Abstract Converting CO 2 into high‐value liquid products is a promising strategy to alleviate energy crisis. Herein, novel Cu/Bi bi‐metal catalyst derived from MOFs has been prepared by hydrothermal synthesis combining with high temperature calcination under N atmosphere, which shows cylindrical morphology composed of bi‐metallic nanoparticles. It found that system beneficial lower the activate barrier and stronger adsorption capability for ⋅ − intermediate than reference Bi/Bi O 3 @C...
Photoelectrochemical (PEC) reduction of CO2 to high value-added chemicals or fuel is an effective way remit insufficient energy supply and global warming. Herein, Bi species-modified p-n heterojunction ZnO/p-Si was synthesized by a hydrothermal method subsequent electrodeposition process. For the PEC reaction (CO2RR), obtained photocathode Bi-Bi2O3/ZnO/p-Si not only improves light absorption capacity because p-Si plasma metal Bi, but also increases selectivity products existence species. In...
This paper proposes transforming actual monitoring data into risk quantities and establishing a Long Short-Term Memory (LSTM) safety warning model for predicting the deformation of super-large ultra-deep foundation pits in river–round gravel strata based on evaluation methods. Using this model, short-term predictions at various points are made compared with data. The results from LSTM indicate an absolute error range between predicted values on-site −0.24 to 0.16 mm, demonstrating model’s...
Using renewable energy to convert CO2 into liquid products, as a sustainable way produce fuels and chemicals, has attracted intense attention. Herein, novel heterostructured photocathode composed of Si wafer, TiO2 layer, Sn metal particles been successfully fabricated by combining facile hydrothermal electrodeposition method. The obtained Sn/TiO2 /Si shows enhanced light absorption performance the surface plasmon resonance effect metal. Especially, together with rich oxygen vacancy defects...