A5110366360- High Temperature Alloys and Creep
- Metallurgy and Material Forming
- Radiation Detection and Scintillator Technologies
- Metal Alloys Wear and Properties
- Fatigue and fracture mechanics
- Ga2O3 and related materials
- Aluminum Alloy Microstructure Properties
- Luminescence Properties of Advanced Materials
- Microstructure and Mechanical Properties of Steels
- ZnO doping and properties
- Pelvic floor disorders treatments
- Nuclear Materials and Properties
- Circular RNAs in diseases
- Immune Response and Inflammation
- Inflammatory Bowel Disease
- Advanced Photocatalysis Techniques
- Evaluation Methods in Various Fields
- Perovskite Materials and Applications
- Colorectal Cancer Surgical Treatments
- Optical and Acousto-Optic Technologies
- Histiocytic Disorders and Treatments
- Anorectal Disease Treatments and Outcomes
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- 2D Materials and Applications
China Pharmaceutical University
2025
Guizhou Minzu University
2023-2025
Syracuse University
2025
Southern Medical University Shenzhen Hospital
2025
Zhejiang University
2021-2024
Second Affiliated Hospital of Zhejiang University
2017-2024
Sichuan Agricultural University
2024
China State Construction Engineering (China)
2024
Guizhou University
2022
Guizhou Provincial People's Hospital
2022
The global spread of multidrug-resistant pathogenic fungi presents a serious threat to human health, necessitating the discovery antifungals with unique modes action1. However, conventional activity-based screening for previously undescribed antibiotics has been hampered by high-frequency rediscovery known compounds and lack new antifungal targets2. Here we report polyene antibiotic, mandimycin, using phylogeny-guided natural-product platform. Mandimycin is biosynthesized mand gene cluster,...
Mounting evidences have indicated that long noncoding RNAs (lncRNAs) play pivotal roles in human diseases, especially cancers. Recently, TINCR was proposed to be involved tumor progression. However, its role colorectal cancer (CRC) remains elusive. In our study, we found SP1-induced significantly upregulated CRC tissues and cell lines. Moreover, cox multivariate survival analysis revealed high an independent predictor of poor overall (OS). Functionally, knockdown obviously suppressed cells...
Currently, WeChat is widely used in disease education for patients with Crohn's (CD) China. It beneficial the to actively engage their management. In this study, we examined source and expectations of information Chinese CD patients, analysing content popular public accounts potential association medication adherence. Between November 24th, 2017 April 10th, 2018, online questionnaires were sent from eight different large urban hospitals all, 436 surveyed, 342 responded. Patients most...
Septic shock comprises a heterogeneous population, and individualized resuscitation strategy is of vital importance. The study aimed to identify subclasses septic with non-supervised learning algorithms, so as tailor for each class.Patients in 25 tertiary care teaching hospitals China from January 2016 December 2017 were enrolled the study. Clinical laboratory variables collected on days 0, 1, 2, 3 7 after ICU admission. Subclasses identified by both finite mixture modeling K-means...
Hypoxia plays a key role in colorectal cancer (CRC) metastasis, but its underlying mechanism remains largely unknown. Dicer1, an RNase, has been considered as tumor regulator many tumors. However, whether Dicer1 affects CRC progression under hypoxia uncertain. In this study, we found that expression was induced by cells and it mediates hypoxia-induced cell progression. Furthermore, the of tRF-20-MEJB5Y13, small non-coding RNA derived from tRNA, increased hypoxic conditions, upregulation...
GH4169 alloy is a nickel-based superalloy extensively used in the aircraft engine industry because of its excellent mechanical properties and good fabrication ability. The at high temperature, rupture stress under severe condition deserves close attention. In this paper, creep constant load different temperatures from 550 °C to 700 conditions systematically evaluated major impact factors behavior are analyzed. Furthermore, an improving method for proposed.
BACKGROUND:An increasing number of studies have demonstrated that Streptococcus bovis and its concomitant inflammatory factors concentrate in the intestine colorectal cancer (CRC). However, molecular mechanism S. on tumorigenesis remains unclear. This study aimed to explore role carcinogenesis potential CRC mice orally pretreated with bovis. MATERIAL AND METHODS:The colons experimental were collected evaluated for extent neoplasm. In addition, comparative feces DNA sequencing was adopted...
The rapid emergence of difficult-to-treat multidrug-resistant pathogens, combined with the scarcity antibiotics possessing novel mechanisms, poses a significant threat to global public health. Here, we integrated synthetic-bioinformatic natural product approach peptide optimization unveil antibiotic-producing potential Paenibacillaceae bacteria. Our culture-independent led discovery paenimycin, 11-mer depsi-lipopeptide featuring an unprecedented dual-binding mechanism. By sequestering...
Enhancement of the perovskite film quality and charge transfer capability is crucial for enhancing device performance. The all-inorganic CsPbCl3 perovskite, which shows great potential as an absorber layer in ultraviolet photodetectors (UV PDs), has been hindered by poor material stability high interface states, limiting its widespread application. In this work, films perovskite/Au electrode were synergistically modulated using V2CTx MXene. After additive (CsPbCl3@V2CTx) (CsPbCl3/V2CTx)...
We investigated the effects of salt-sensitive signaling molecules on ionic fluxes and gene expression related to K+/Na+ homeostasis in a perennial herb, Glycyrrhiza uralensis, during short-term NaCl stress (100 mM, 24 h). Salt treatment caused more pronounced Na+ accumulation root cells than leaf cells. ions were mostly compartmentalized vacuoles. Roots exposed showed increased levels extracellular ATP (eATP), cytosolic Ca2+, H2O2, NO. Steady-state flux recordings revealed that these...
Some studies show that cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) may improve overall survival and is a possible curative treatment for selected colorectal cancer (CRC) patients restricted peritoneal metastasis (PM). The value of HIPEC in preventing PM CRC still controversial.