A5047935427- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Lipid metabolism and disorders
- Radiomics and Machine Learning in Medical Imaging
- Intraperitoneal and Appendiceal Malignancies
- Genetic factors in colorectal cancer
- PI3K/AKT/mTOR signaling in cancer
- Fibroblast Growth Factor Research
- Estrogen and related hormone effects
- Colorectal Cancer Treatments and Studies
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Appendicitis Diagnosis and Management
- Colorectal Cancer Screening and Detection
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Hedgehog Signaling Pathway Studies
- Liver Diseases and Immunity
Second Affiliated Hospital of Zhejiang University
2014-2024
Zhejiang University
2012-2024
Zhejiang Cancer Hospital
2022
George Washington University
2021
Ministry of Education of the People's Republic of China
2017-2019
MRC Laboratory of Molecular Biology
2012-2014
Microsatellite stable (MSS) and RAS-mutant metastatic colorectal cancer (mCRC) patients are characterized by an immunosuppressive microenvironment a low response rate to immunotherapy. Chemotherapy anti-angiogenesis therapy have been reported potentially promote immunotherapy response. This study aims assess the preliminary anti-tumor activity safety of sintilimab plus bevacizumab, oxaliplatin capecitabine as treatment option for with MSS mCRC.
Targeting SBPTN1 with siRNA has the potential to treat NASH and prevent HCC.
Immune checkpoint inhibitors (ICIs) offer new options for the treatment of patients with solid cancers worldwide. The majority colorectal (CRC) are proficient in mismatch-repair (pMMR) genes, harbors few tumor antigens and is insensitive to ICIs. These tumors often found be immune-deserted. We hypothesized that forcing immune cell infiltration into microenvironment followed by ignition PD1 blockade may initiate a positive cycle can boost antitumor immunity. Bioinformatics using public...
MicroRNA-21 (miR-21) is overexpressed in the serum of patients with colorectal cancer (CRC), suggesting that miR-21 a promising diagnostic biomarker for CRC. Therefore, meta-analysis was performed to assess value CRC patients. This included 9 studies 746 and 476 healthy controls. Two independent researchers identified extracted study characteristics from eligible were searched literature databases. The quality assessed accordance Quality Assessment Diagnostic Accuracy Studies. Bivariate...
Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung breast cancer, acting as a novel tumor suppressor candidate. Nevertheless, its effects on colorectal cancer (CRC) remain poorly defined. In this study, we aim demonstrate the biological function of ANGPTL1 CRC cells.We explored mRNA expression human tissues association with prognosis. cell lines overexpressing or knocked down were constructed analyzed for changes proliferation, colony...
Some studies show that cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) may improve overall survival and is a possible curative treatment for selected colorectal cancer (CRC) patients restricted peritoneal metastasis (PM). The value of HIPEC in preventing PM CRC still controversial.
An enhanced anti-apoptotic capacity of tumor cells plays an important role in the process breakpoint cluster region/Abelson tyrosine kinase gene (BCR/ABL)-independent imatinib resistance. We have previously demonstrated that brain expressed X-linked 1 (BEX1) was silenced secondary imatinib-resistant K562 and re-expression BEX1 can restore sensitivity resulting induction apoptosis. However, mechanism by which executes its pro-apoptotic function remains unknown. identified B-cell lymphoma 2...
The incidence of colorectal cancer is increasing, and metastasis one the major causes poor outcomes. BEX2 has been reported to be involved in tumor development several types cancer, but its role metastatic remains largely undefined. Herein, we demonstrated that knockout resulted enhanced migratory potential cells both vitro vivo, re-expression could reverse capacity. RNA-Seq results indicated hedgehog signaling pathway was activated after knockout; moreover, inhibitors, GANT61 GDC-0449...
BEX2 has been suggested to promote the tumor growth in breast cancer and glioblastoma, while inhibit proliferation of glioma cells.Thus, role was still debate.Additionally, biological functions colorectal (CRC) have not yet clarified.Here, we reported that overexpressed advanced CRC from both GSE14333 database fresh tissue specimens, positively correlated with clinical staging.Knockdown significantly decreased vitro SW620 cells, suppressed subcutaneous xenograft enhanced survival mice cecal...
The cooperation and communication between different cell signaling transduction pathways are considered critical in the development of various types cancer as well drug resistance. There is evidence crosstalk G protein-coupled receptor 30 (GPR30), newly discovered estrogen (ER), ErbB family. Heregulin (HRG)-β1, ligand for ErbB3 ErbB4, upregulates GPR30 expression MCF-7, T-47D BT-474 breast lines that express ERα. In present study, recombinant human HRG-β1 was used to investigate upregulation...
Integrins, as a large family of cell adhesion molecules, play crucial role in maintaining intestinal homeostasis. In inflammatory bowel disease (IBD), homeostasis is disrupted. Integrin αvβ6, which mainly regulated by the integrin β6 subunit gene (ITGB6), molecule that mediates cell-cell and cell-matrix interactions. However, ITGB6 pathogenesis IBD remains elusive. this study, we found was markedly upregulated inflamed tissues from patients with IBD. Then, generated an epithelial...
Our prior research revealed that the tumor enhancement ratio (TER) on triphasic abdominal contrast-enhanced MDCT (CE-MDCT) scans was a prognostic factor for patients with stages I-III colon cancer. Building upon this finding, present study aims to investigate proteomic changes in cancer varying TER values.TER analyzed preoperative CE-MDCT of 160 patients. The survival outcomes those low-TER and high-TER groups were compared. Proteomic analysis tissues performed by mass spectrometry (MS)...