A5100417155- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Chronic Kidney Disease and Diabetes
- Galectins and Cancer Biology
- Stress Responses and Cortisol
- Diabetes and associated disorders
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Biochemical Analysis and Sensing Techniques
- Immune cells in cancer
- Diabetes Management and Research
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Drug Transport and Resistance Mechanisms
- Natural product bioactivities and synthesis
- Sepsis Diagnosis and Treatment
Shanghai University of Traditional Chinese Medicine
2016-2025
Jiangxi Agricultural University
2021-2025
Boston Children's Hospital
2017-2025
Boston Children's Museum
2022-2025
Shenzhen Bao'an District People's Hospital
2012-2025
University of Iowa
2025
Zhongshan Hospital of Xiamen University
2014-2024
Zhejiang University
2020-2024
Nanjing Drum Tower Hospital
2020-2024
Shenzhen University Health Science Center
2018-2024
Background. Plasma concentrations of tenofovir increase when the drug is coadministered with some ritonavirboosted protease inhibitors (PI/r). We hypothesized that disoproxil fumarate (TDF)-treated patients taking PI/r-based regimens would have a greater decline in renal function than receiving nonnucleoside reversetranscriptase inhibitor (NNRTI)- based therapy.
Abstract Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated female sex distinctive comorbidities. During...
The microglia cell transfer has been shown to play a protective role in ischemic stroke. Microglia cells may this nerve-protective via the promotion of angiogenesis. However, underlying mechanisms are largely unknown and need further investigation.The aim study was investigate pro-angiogenesis effects unpolarized, interleukin-4 (IL-4)-polarized or lipopolysaccharide (LPS)-polarized BV2 both vivo vitro. We also investigated potential these effects.BV2 were polarized using phosphate-buffered...
Better understanding of the association between characteristics patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management.
The application of RNA interference (RNAi) technology for pest control is environmentally friendly and accurate. However, the efficiency RNAi often inconsistent unreliable, finding a suitable carrier element considered critical to success in overcoming biotic abiotic barriers reach target site. fall armyworm, Spodoptera frugiperda (FAW), which one most important global agricultural pests, has recently spread rapidly other parts world. In this study, method improve stability dsRNA complex was...
Objective: Autoimmune thyroid disease is an organ-specific disorder due to the interplay between environmental and genetic factors. Toll-like receptors are pattern recognition expressed abundantly on monocytes. There a paucity of data TLR expression in autoimmune (AITD). The aim this study was examine expression, activation, ligands, downstream signaling adaptors PBMCs extracted from untreated patients healthy controls. Method: We isolated peripheral blood mononuclear cells (PBMC) 30...
Abstract Background FAT4 (FAT Atypical Cadherin 4) is a member of the cadherin-associated protein family, which has been shown to function as tumor suppressor by inhibiting proliferation and metastasis. The Wnt/β-catenin pathway activation highly associated with PD-L1-associated immune escape. Here, we report mechanism overexpression regulates anti-tumor immunity in cervical cancer PD-L1 N-glycosylation cell membrane localization β-catenin-dependent manner. Methods expression was first...
Abstract The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the IgM N-glycosylation has not been studied viral infection. analysis from healthy controls hospitalized disease 2019 (COVID-19) patients reveals increased high-mannose sialylation that correlates with COVID-19 severity. These trends are confirmed within SARS-CoV-2-specific...
It is generally accepted that cognitive processes, such as learning and memory, are affected in depression. The present study used a rat model of depression, chronic unpredictable mild stress (CUMS), to determine whether hippocampal volume neurochemical changes were involved memory alterations. A further aim was these effects could be ameliorated by escitalopram treatment, assessed with the non-invasive techniques structural magnetic resonance imaging (MRI) spectroscopy (MRS). Our results...
In the United States, sexually transmitted infections (STIs) confer significant morbidity in adolescents and young adults. STIs are not well characterized transgender other gender minority youth (TGMY) who have a identity that differs from sex assigned to them at birth. This study sought fill this gap. 2015–2016, Adolescent Medicine Trials Network for HIV/AIDS Interventions conducted Protocol 130, Affirming Voices Action, enrolling diverse sample of TGMY 16–24 years age 14 US geographic...
Rationale: Although human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation has been proved to be an effective therapeutic approach treat systemic lupus erythematosus (SLE), the detailed underlying mechanisms are not fully understood.Transferring miRNAs is one mean by which MSCs communicate with surrounding cells.Sirt1 a NAD-dependent deacetylase that protects against cell senescence deacetylating p53.Here we aimed explore whether hUC-MSCs affected of splenic CD4+ T...
Neuroimaging and genetic testing have been proposed for diagnostic evaluation of infantile spasms (IS), establishing etiology in ~60% multicenter IS cohorts. A retrospective analysis the yield following an institutionally established guideline investigation/treatment was conducted, association between etiological subgroups sustained response to standard treatment evaluated.Etiology IS, neuroimaging, results were extracted from clinical records. Etiology categorized as acquired or...
Adriamycin (ADR) administration in susceptible rodents such as the BALB/c mouse strain produces injury to glomerulus mimicking human focal glomerular sclerosis. The goal of present study was use this model investigate antiproteinuric action nitro-oleic acid (OA-NO2), a nitric oxide-derived endogenous lipid product, which has exhibited multiple attractive signaling properties particularly kidney. mice were pretreated for 2 days with OA-NO2 at 5 mg·kg(-1)·day(-1) via an osmotic minipump,...
New 3-drug regimens have been developed and approved to treat multiple myeloma (MM). The absence of direct comparative data the high cost treatment support need assess relative clinical economic outcomes across all regimens.
Noncommunicable diseases (NCDs) are a major threat to population health worldwide. In Shanghai, China, new pattern of NCD management-self-management-has been developed in community service centres (CHSCs).To clarify how contracting with CHSC-based family doctors (FDs) influences the engagement and effectiveness self-management behaviour among patients.We conducted two waves questionnaire survey (in 2013 2016) collect data on patients NCDs. Separate logistic regression models longitudinal...