A5076676906- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Psoriasis: Treatment and Pathogenesis
- Hepatitis C virus research
- HIV-related health complications and treatments
- Pharmaceutical Practices and Patient Outcomes
- Peptidase Inhibition and Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacological Effects and Toxicity Studies
- Autoimmune Bullous Skin Diseases
- Chronic Lymphocytic Leukemia Research
- Antibiotic Use and Resistance
- Migraine and Headache Studies
- Colorectal Cancer Treatments and Studies
- Pharmaceutical studies and practices
- Immunodeficiency and Autoimmune Disorders
- Ferroptosis and cancer prognosis
- Mobile Health and mHealth Applications
- Tumors and Oncological Cases
- Tuberous Sclerosis Complex Research
- Artificial Intelligence in Healthcare and Education
- Lymphoma Diagnosis and Treatment
- Pharmacy and Medical Practices
- Histiocytic Disorders and Treatments
Complejo Hospitalario de Jaén
2023-2024
Scripps Clinic
2014-2024
Complejo Hospitalario Torrecárdenas
2022
Scripps Health
2014-2020
Scripps Green Hospital
2019
Hospital Universitario Virgen de las Nieves
2014-2016
Complejo Hospitalario Universitario de Granada
2016
University of California, San Diego
2004-2011
VA San Diego Healthcare System
2009
Sarepta Therapeutics (United States)
2006-2008
Background. Plasma concentrations of tenofovir increase when the drug is coadministered with some ritonavirboosted protease inhibitors (PI/r). We hypothesized that disoproxil fumarate (TDF)-treated patients taking PI/r-based regimens would have a greater decline in renal function than receiving nonnucleoside reversetranscriptase inhibitor (NNRTI)- based therapy.
Suboptimal CD4+ T cell recovery during antiretroviral therapy (ART) is a common clinical dilemma.We analyzed viral and immunologic predictors of in 116 human immunodeficiency virus type 1 (HIV-1)-infected subjects who had suppressed viremia (< or = 50 copies/mL) while receiving ART. Successive measurements immunophenotypes cellular HIV-1 DNA levels were obtained before receipt On the basis increases count, classified as immunologically concordant (demonstrating an increase > 100 cells/mm3)...
Objective: We conducted a randomized, multi-site, controlled trial of cognitive-behavioral adherence intervention for patients initiating or changing an antiretroviral (ART) regimen. Design: A 3 × 2 factorial design was used with the primary randomization assigning (1: 1: 1) to one two interventions usual care. Methods: The five-session consisted cognitive–behavioral and motivational components, without 2-week pre-treatment placebo practice trial. Intent-to-treat analysis probability weights...
Objective: To improve the utility of therapeutic drug monitoring (TDM) by defining proportion patients with and predictors above or below target protease inhibitor (PI) nonnucleoside reverse transcriptase (NNRTI) concentrations. Methods: This 48-week, multicenter, open-label clinical trial randomized to TDM versus standard care (SOC). Serial pharmacokinetics, including a week-2 3-sample sparse collection, expert committee recommendations were given TDM-arm patients' providers. Results:...
To identify a pre-HAART gene expression signature in peripheral blood mononuclear cells (PBMCs) predictive of CD4 T-cell recovery during HAART HIV-infected individuals.This retrospective study evaluated PBMC 24 recently individuals before the initiation to genes whose is after 48 weeks HAART.The change count (DeltaCD4) over 48-week period was calculated for each participants. Twelve participants were assigned 'good' (DeltaCD4 > or = 200 cells/microl) and 12 'poor' < group. Gene profiling...
We assessed the effectiveness of a Lactobacillus probiotic on rates health care facility-onset Clostridium difficile infection (HO-CDI) in patients receiving antibiotics. A total 1576 were evaluated. There was no difference HO-CDI incidence between those who received probiotics and did not (1.8% vs 0.9%; P = .16).
To evaluate a potential pharmacodynamic/pharmacokinetic interaction between abacavir (ABC) and tenofovir disoproxil fumarate (TDF).This randomized trial compared 7 days of ABC or TDF monotherapy, separated by 35-day washout, with + dual-therapy in treatment-naive, HIV-1-infected patients. During each 7-day course, the slope phase I viral decay was estimated steady-state intracellular concentrations carbovir triphosphate (CBV-TP), deoxyguanosine (dGTP), diphosphate (TFV-DP) deoxyadenosine...
To develop a computer-based system for modelling and interpreting plasma antiretroviral concentrations therapeutic drug monitoring (TDM).Data were extracted from prospective TDM study of 199 HIV-infected patients (CCTG 578). Lopinavir (LPV) efavirenz (EFV) pharmacokinetic (PK) parameters modelled using Bayesian method interpreted by an expert committee HIV specialists pharmacologists who made recommendations. These PK models recommendations formed the knowledge base to artificial...
We aimed to determine the reliability and validity of a hepatitis symptom inventory identify predictors C (HCV) treatment initiation in cohort HIV-infected patients. Prospective clinic based study that enrolled patients referred for HCV therapy consideration. A Center Epidemiologic Studies Depression Scale (CES-D) were administered HIV/HCV individuals. The was factor analyzed subscale estimated with Cronbach's alpha. Predictive evaluated using generalized estimating equations (GEE)....
Background: Nucleos(t)ide reverse transcriptase inhibitor (NRTI)-sparing regimens may potentially minimize antiretroviral (ART) toxicities, but demonstrate mixed efficacy and toxicity results. The impact of an integrase strand transfer (INSTI) protease (PI) regimen on HIV viral dynamics T cell kinetics remains underdescribed.Objective: To compare the effect raltegravir + ritonavir boosted lopinavir (RAL LPV/r) to efavirenz/tenofovir disoproxil fumarate/emtricitabine (EFV/TDF/FTC)...
<h3>Background and Importance</h3> Immunotherapy has emerged as a revolutionary approach to the treatment of small-cell lung cancer. This aggressive form cancer presents significant challenges due limited therapeutic response even resistance conventional chemotherapy. However, strategy combining immunotherapy with chemotherapy makes it possible stimulate patient's own immune system fight cells, triggering specific response. novel combination shown promising results in improving survival...
<h3>Background and Importance</h3> Atopic dermatitis (AD) is a chronic inflammatory skin disease characterised by severe pruritus, eczema xerosis. A systemic treatment option for moderate-severe AD tralokinumab, human monoclonal antibody targeting IL-13. <h3>Aim Objectives</h3> The aim of the study to evaluate effectiveness safety tralokinumab in patients with three tertiary hospitals. <h3>Material Methods</h3> Observational, retrospective, multicentred treated from April 2022 September...
<h3>Background and Importance</h3> Anti-interleukin 23 drugs were approved in the last 6 years. The absence of long-term comparison between alternatives such as risankizumab or guselkumab needs to be fulfilled. <h3>Aim Objectives</h3> To evaluate effectiveness through indirect comparisons plaque psoriasis treatment. <h3>Material Methods</h3> Multicentric, retrospective observational study. Comparison made with patients active treatment September 2023 overcoming 52 weeks Demographic (sex,...