A5016777889- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Urinary Tract Infections Management
- HIV/AIDS Research and Interventions
- Clostridium difficile and Clostridium perfringens research
- Infection Control in Healthcare
- HIV/AIDS drug development and treatment
- Infective Endocarditis Diagnosis and Management
- Bacterial biofilms and quorum sensing
- Pediatric Urology and Nephrology Studies
- HIV Research and Treatment
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Urinary Bladder and Prostate Research
- Antifungal resistance and susceptibility
- HIV-related health complications and treatments
- Surgical site infection prevention
- Drug-Induced Adverse Reactions
- SARS-CoV-2 and COVID-19 Research
- Orthopedic Infections and Treatments
- Mycobacterium research and diagnosis
- Medical Device Sterilization and Disinfection
Harbor–UCLA Medical Center
2016-2025
UCLA Medical Center
2016-2025
University of California, Los Angeles
2014-2024
The Lundquist Institute
2014-2024
Los Angeles Medical Center
2007-2024
CNR de la Résistance aux Antibiotiques
2022
Torrance Memorial Medical Center
2019-2021
Museum of Heilongjiang Province
2021
Texas Health Dallas
2020
Cornell University
2020
Necrotizing fasciitis is a life-threatening infection requiring urgent surgical and medical therapy. Staphylococcus aureus has been very uncommon cause of necrotizing fasciitis, but we have recently noted an alarming number these infections caused by community-associated methicillin-resistant S. (MRSA).
The need for new antimicrobial agents is greater than ever because of the emergence multidrug resistance in common pathogens, rapid infections, and potential use multidrug-resistant bioweapons. Paradoxically, some pharmaceutical companies have indicated that they are curtailing anti-infective research programs. We evaluated United States Food Drug Administration (FDA) databases approved drugs development programs world's largest biotechnology to document trends agents. FDA approval...
Background: Poor adherence to HIV protease inhibitors may compromise the effectiveness of treatment. Few studies have compared methods for measuring or related measures a clinical outcome. Objective: To examine relationship among composite score adherence, three primary and virologic response. Design: Longitudinal cohort study. Setting: Public clinic. Patients: 108 HIV-infected adults receiving non-nucleoside reverse transcriptase who were monitored 666 monthly intervals. Measurements:...
Background: Infection with multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus (MRSA) has been reported but seems to be isolated. Objective: To determine the incidence of a multidrug-resistant MRSA clone (USA300) in San Francisco, and risk factors for infection. Design: Population-based survey cross-sectional study using chart review. Setting: 9 hospitals Francisco (population-based survey) 2 outpatient clinics Boston (cross-sectional study). Patients:...
Abstract We noted a marked increase in healthcare-associated (HA) methicillin-resistant Staphylococcus aureus (MRSA) infections caused by isolates phenotypically consistent with community-associated (CA)-MRSA strains. To study this trend, we retrospectively examined all HA-MRSA from patients our institution during 1999–2004. An isolate was considered an SCCmecIV phenotype if it had antimicrobial drug susceptibilities typical CA-MRSA isolates. Our phenotypic definition validated limited...
The increasing multidrug resistance among gram-negative uropathogens necessitates new treatments for serious infections. Plazomicin is an aminoglycoside with bactericidal activity against multidrug-resistant (including carbapenem-resistant) Enterobacteriaceae.
Skin and skin-structure infections are common in ambulatory settings. However, the efficacy of various antibiotic regimens era community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is unclear.We enrolled outpatients with uncomplicated skin who had cellulitis, abscesses larger than 5 cm diameter (smaller for younger children), or both. Patients were at four study sites. All underwent incision drainage. randomly assigned a 1:1 ratio to receive either clindamycin...
Uncomplicated skin abscesses are common, yet the appropriate management of condition in era community-associated methicillin-resistant Staphylococcus aureus (MRSA) is unclear.We conducted a multicenter, prospective, double-blind trial involving outpatient adults and children. Patients were stratified according to presence surgically drainable abscess, abscess size, number sites infection, nonpurulent cellulitis. Participants with 5 cm or smaller diameter enrolled. After incision drainage,...
In maintenance hemodialysis (MHD) patients, hepatitis C virus (HCV) infection is common and may be associated with poor clinical outcomes. It was hypothesized that HCV would high all-cause cardiovascular mortality in these patients after controlling for demographic characteristics, including surrogates of malnutrition-inflammation complex syndrome. A national database 13,664 MHD who underwent antibody serology testing at least once during a 3-yr interval (July 2001 through June 2004)...
The emergence of community-associated methicillin-resistant S. aureus was associated with dramatically increased skin and soft tissue infection (SSTI) incidence in the first few years 21st century U.S. However, subsequent trends are poorly understood. We examined ambulatory inpatient data over 48 million persons aged 0–64 from HealthCore Integrated Research Database (HIRD) between 2005 2010. Data were extracted medical, pharmacy, eligibility databases. quantified SSTI incidence, type,...
Treatments for health care-associated infections (HAIs) caused by antibiotic-resistant bacteria and Clostridium difficile are limited, some patients have developed untreatable infections. Evidence-supported interventions available, but coordinated approaches to interrupt the spread of HAIs could a greater impact on reversing increasing incidence these than independent facility-based program efforts.Data from CDC's National Healthcare Safety Network Emerging Infections Program were analyzed...
The emergence of community-associated methicillin-resistant Staphylococcus aureus (SA) and its role in skin soft tissue infections (SSTIs) accentuated the SA-SSTIs hospitalizations.We used Nationwide Inpatient Sample Census Bureau data to quantify population-based incidence associated cost for SA-SSTI hospitalizations.SA-SSTI hospitalizations increased 123% from 160,811 358,212 between 2001 2009, they represented an increasing share SA- (39% 51%). (per 100,000 people) doubled 57 117 2009...
Hospitalized patients who are colonized with methicillin-resistant Staphylococcus aureus (MRSA) at high risk for infection after discharge.
The USA300 methicillin resistant Staphylococcus aureus (MRSA) genetic background has rapidly emerged as the predominant cause of community-associated S. infections in U.S. However, epidemiologic characteristics household transmission are poorly understood.