Alison D. Augustine
A5091003367- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Mosquito-borne diseases and control
- Malaria Research and Control
- Biomedical Text Mining and Ontologies
- Bioinformatics and Genomic Networks
- Immune responses and vaccinations
- Effects of Radiation Exposure
- Genomics and Rare Diseases
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
- Tryptophan and brain disorders
- interferon and immune responses
- Complement system in diseases
- Biochemical effects in animals
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Outbreaks Research
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Invertebrate Immune Response Mechanisms
- Spaceflight effects on biology
- Adipokines, Inflammation, and Metabolic Diseases
- Cell Image Analysis Techniques
- Vaccine Coverage and Hesitancy
National Institute of Allergy and Infectious Diseases
2010-2025
National Institutes of Health
2009-2025
National Institute of Infectious Diseases
2023
A priority for the National Institute of Allergy and Infectious Diseases is development a universal influenza vaccine providing durable protection against multiple strains. NIAID will use this strategic plan as foundation future investments in research.
Aging | doi:10.18632/aging.100531. T. Kevin Howcroft, Judith Campisi, Germaine Buck Louis, Martyn Smith, Bradley Wise, Tony Wyss-Coray, Alison Deckhut Augustine, Janet E. McElhaney, Ron Kohanski, Felipe Sierra
Better understanding of the association between characteristics patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management.
The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1–3) to more severe disease course (TG4) and death (TG5). Here, we report deep immunophenotyping, profiling >15,000 longitudinal blood nasal samples 540 participants the using 14 distinct assays. These unbiased analyses identify cellular molecular signatures present within 72 h hospital admission that...
IMPACC is a multicenter longitudinal study assessing clinical and immunologic manifestations of COVID-19 in hospitalized patients.
Abstract The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the IgM N-glycosylation has not been studied viral infection. analysis from healthy controls hospitalized disease 2019 (COVID-19) patients reveals increased high-mannose sialylation that correlates with COVID-19 severity. These trends are confirmed within SARS-CoV-2-specific...
Age is a major risk factor for severe coronavirus disease 2019 (COVID-19), yet the mechanisms behind this relationship have remained incompletely understood. To address this, we evaluated impact of aging on host immune response in blood and upper airway, as well nasal microbiome prospective, multicenter cohort 1031 vaccine-naïve patients hospitalized COVID-19 between 18 96 years old. We performed mass cytometry, serum protein profiling, anti–severe acute respiratory syndrome 2 (SARS-CoV-2)...
Current events throughout the world underscore growing threat of different forms terrorism, including radiological or nuclear attack. Pharmaceutical products and other approaches are needed to protect civilian population from radiation treat those with radiation-induced injuries. In event an attack, exposures will be heterogeneous in terms both dose quality, depending on type device used each victim's location relative source. Therefore, methods against a wide range early slowly developing...
Abstract Age is a major risk factor for severe coronavirus disease-2019 (COVID-19), yet the mechanisms responsible this relationship have remained incompletely understood. To address this, we evaluated impact of aging on host and viral dynamics in prospective, multicenter cohort 1,031 patients hospitalized COVID-19, ranging from 18 to 96 years age. We performed blood transcriptomics nasal metatranscriptomics, measured peripheral immune cell populations, inflammatory protein expression,...
Chronic viral infections are ubiquitous in humans, with individuals harboring multiple latent viruses that can reactivate during acute illnesses. Recent studies have suggested SARS-CoV-2 infection lead to reactivation of such as Epstein-Barr Virus (EBV) and cytomegalovirus (CMV), yet, the extent impact COVID-19 its effect on host immune system remain incompletely understood. Here we present a comprehensive multi-omic analysis all known chronically infecting 1,154 hospitalized patients, from...
Hospitalized COVID-19 patients exhibit diverse clinical outcomes, with some individuals diverging over time even though their initial disease severity appears similar. A systematic evaluation of molecular and cellular profiles the full course can link immune programs coordination progression heterogeneity. In this study, we carried out deep immunophenotyping conducted longitudinal multi-omics modeling integrating ten distinct assays on a total 1,152 IMPACC participants identified several...
Abstract Hospitalized COVID-19 patients exhibit diverse immune responses during acute infection, which are associated with a wide range of clinical outcomes. However, understanding these heterogeneities and their links to various complications, especially long COVID, remains challenge. In this study, we performed unsupervised subtyping longitudinal multi-omics immunophenotyping in over 1,000 hospitalized patients, identifying two critical subtypes linked mortality or mechanical ventilation...
On September 16, 2009, the National Institute of Allergy and Infectious Diseases (NIAID), part U.S. Institutes Health, convened a workshop to discuss current knowledge T- B-cell immune epitopes for members Flavivirus genus (family Flaviviridae), how this information could be used increase our basic understanding host-pathogen interactions and/or advance development new or improved vaccines diagnostics these pathogens. T-cell responses flaviviruses are critical components protective immunity...
ABSTRACT Background Better understanding of the association between characteristics patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management. Methods Im muno p henotyping A ssessment in a C OVID-19 ohort (IMPACC) prospective, observational study 1,164 from 20 hospitals across United States. Disease severity was assessed using 7-point ordinal scale based on degree respiratory illness. Patients were prospectively surveyed...
The Cell Ontology (CL) is an OBO Foundry candidate ontology intended for the representation of cell types from all biology. A recent workshop sponsored by NIAID on hematopoietic in CL addressed issues both content and structure CL. section dealing with cells was extensively revised, plans were made restructuring these type terms as cross-products logical definitions based relationships to external ontologies, such Protein Gene Ontology. improvements this area represent a paradigm future...
Abstract The Cell Ontology (CL) aims for the representation of in vivo and vitro cell types from all biology. Although CL is a reference ontology OBO Foundry, it requires extensive revision to bring up current standards biomedical ontologies, both its structure coverage various subfields A recent workshop sponsored by NIAID on hematopoietic addressed issues. section dealing with cells was extensively revised, plans were set structuring these type terms as cross-products logical definitions...