A5057880535- Influenza Virus Research Studies
- Lipid Membrane Structure and Behavior
- Immune responses and vaccinations
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Disease and Adiposity
- Long-Term Effects of COVID-19
- COVID-19 Impact on Reproduction
- Vaccine Coverage and Hesitancy
- Effects of Radiation Exposure
- Photoacoustic and Ultrasonic Imaging
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Telomeres, Telomerase, and Senescence
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Complement system in diseases
- Atherosclerosis and Cardiovascular Diseases
- Vitamin C and Antioxidants Research
- Cannabis and Cannabinoid Research
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Mast cells and histamine
National Institute of Allergy and Infectious Diseases
2013-2024
National Institutes of Health
2011-2024
United States Department of Health and Human Services
2013
Millennium Engineering and Integration (United States)
2001
Abstract Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in wide range biological functions. These expressed predominantly by myeloid cells recognize variety ligands including endogenous modified host-derived molecules microbial pathogens. There currently eight classes scavenger receptors, many which have multiple names, leading to inconsistencies confusion the literature. To address this problem, workshop was organized United States...
As COVID-19 continues, an increasing number of patients develop long COVID symptoms varying in severity that last for weeks, months, or longer. Symptoms commonly include lingering loss smell and taste, hearing loss, extreme fatigue, "brain fog." Still, persistent cardiovascular respiratory problems, muscle weakness, neurologic issues have also been documented. A major problem is the lack clear guidelines diagnosing COVID. Although some studies suggest due to prolonged inflammation after...
Exposure to ionizing radiation causes acute damage and loss of bone marrow peripheral immune cells that can result in high mortality due reduced resistance infections hemorrhage. Besides these effects, tissue from trigger inflammatory responses, leading progressive chronic by radiation-induced cell types are required for resolving injuries. Understanding the mechanisms involved system injury repair will provide new insights developing medical countermeasures help restore homeostasis. For...
The hematopoietic system is highly sensitive to ionizing radiation. Damage the immune may result in opportunistic infections and hemorrhage, which could lead mortality. Inflammation triggered by tissue damage can also additional local or widespread damage. responsible for repair restoration, made more challenging when it process of self-recovery. Because these challenges, Radiation Nuclear Countermeasures Program (RNCP) Basic Immunology Branch (BIB) under Division Allergy, Immunology,...
Myelopoiesis and lymphopoiesis are controlled by haematopoietic growth factors, including cytokines, chemokines that bind to G-protein-coupled receptors (GPCRs). Regulators of G-protein signalling (RGSs) a protein family can act as GTPase-activating proteins for Gαi- Gαq-class proteins. We have identified new member the R4 subfamily RGS proteins, RGS18. RGS18 contains clusters hydrophobic basic residues, which characteristic an amphipathic helix within its first 33 amino acids. mRNA was most...
About 12.5% of all maternal deaths in the United States are due to infectious causes. This proportion, although stable during past three decades, represents an increase causes mortality, as overall mortality rate U.S. pregnant women had increased steadily that same period. During healthy pregnancies, a delicate immunological balance-in which mother's immune system tolerates semi-allogeneic fetus yet maintains competency against agents-is achieved and maintained. paradigm, however, results...
Goals for immunization in older adults may differ from those young and children, whom complete prevention of disease is the objective. Often, reduced hospitalization death but also averting exacerbation underlying chronic illness, functional decline, frailty are important goals age group. Because effect on dendritic cell function, T cell‐mediated immune suppression, proliferative capacity cells, other responses, efficacy vaccines often wanes with advanced age. This article summarizes...
Abstract The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since late 2019 represented an unprecedented public health emergency, which included a need to fully understand disease (COVID-19) across all ages and populations. In response, the US National Institute Allergy Infectious Diseases (NIAID) rapidly funded epidemiology studies that monitored COVID-19. However, diversity breadth populations studied in NIAID-funded COVID-19 observational cohorts were not easy...