A5088776357- Effects of Radiation Exposure
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Carcinogens and Genotoxicity Assessment
- Burn Injury Management and Outcomes
- Advanced Radiotherapy Techniques
- Hematopoietic Stem Cell Transplantation
- Vitamin C and Antioxidants Research
- Cell death mechanisms and regulation
- Prenatal Screening and Diagnostics
- Cancer Risks and Factors
- Radiation Effects and Dosimetry
- Spaceflight effects on biology
- Chemotherapy-induced cardiotoxicity and mitigation
- Nuclear Issues and Defense
- Plant Genetic and Mutation Studies
- Chemotherapy-related skin toxicity
- Long-Term Effects of COVID-19
- Chemical Safety and Risk Management
- Ocular Surface and Contact Lens
- Childhood Cancer Survivors' Quality of Life
- High Altitude and Hypoxia
- Immune Cell Function and Interaction
- Dermatological and COVID-19 studies
- Career Development and Diversity
National Institute of Allergy and Infectious Diseases
2016-2025
National Institutes of Health
2016-2025
United States Department of Health and Human Services
2024
National Institute of Mental Health
2018
Henry M. Jackson Foundation
2015
Uniformed Services University of the Health Sciences
2010-2013
Unifor
2011
Moffitt Cancer Center
2007
Molecular Oncology (United States)
2006
Jawaharlal Nehru Cancer Hospital and Research Centre
2003-2005
As COVID-19 continues, an increasing number of patients develop long COVID symptoms varying in severity that last for weeks, months, or longer. Symptoms commonly include lingering loss smell and taste, hearing loss, extreme fatigue, "brain fog." Still, persistent cardiovascular respiratory problems, muscle weakness, neurologic issues have also been documented. A major problem is the lack clear guidelines diagnosing COVID. Although some studies suggest due to prolonged inflammation after...
Purpose Natural history studies have been informative in dissecting radiation injury, isolating its effects, and compartmentalizing injury based on the extent of exposure elapsed time post-irradiation. Although models are useful for investigating mechanism action isolated subsyndromes development medical countermeasures (MCMs), it is clear that ionizing leads to multi-organ (MOI).
We analyzed the radioprotective effects of gamma-tocotrienol (GT3) on hematopoietic stem cells (HSCs) and progenitor (HPCs) in sublethally irradiated mice. Flow cytometry analysis indicated that radiation depleted HPCs (c-Kit(+), Lin(-)) to 40% at days 2 4 after total-body irradiation (TBI) all treatment groups. The HPC numbers GT3-treated mice recovered almost completely (90%) day 7 but remained vehicle-treated (30%) even 13 TBI. An vitro colony-forming assay sorted HSCs (Lin(-), Sca1(+),...
After the events of September 11, 2001, a decade research on development medical countermeasures (MCMs) to treat victims radiological incident has yielded two FDA-approved agents mitigate acute radiation syndrome. These licensed specifically target mitigation radiation-induced neutropenia and infection potential, while ramifications exposure event in public health emergency could include entire body, causing additional and/or delayed organ/tissue injuries. Anecdotal data as well recent...
δ-Tocotrienol (DT3), a vitamin E isoform, is associated with strong antioxidant and immunomodulatory properties. We confirmed the potent activity in membrane systems showed that DT3 an effective radiation protector mitigator. (4 μM, P < 0.001) inhibited lipid peroxidation mouse liver microsomes nitric oxide (NO) formation (20 μM DT3, 0.01) RAW264.7 cells, murine alveolar macrophage line. In CD2F1 mice exposed to lethal total-body from 60Co γ-radiation source, single subcutaneous (s.c.)...
The roundtable discussion at EPR BioDose 2024 focused on identifying challenges for using biodosimetry in a large nuclear incident and exploring potential solutions to strengthen preparedness response frameworks. This report outlines the major themes discussed, including advancements techniques, scaling operations, future of emergency response. Initiated by International Association Biological Radiation Dosimetry (IABERD), group experts comprised professionals academia, government other...
Thrombopoietin (TPO) receptor agonists lacking sequence homology to TPO were designed by grafting a known peptide into the hinge and/or kappa constant regions of human anti-anthrax antibody. Some these proteins equipotent in stimulating cMpl-r activity vitro and increasing platelet levels vivo. ALXN4100TPO (4100TPO), best agonist this series with Kd 30 nM for cMpl-r, exhibited potent as radiation countermeasure CD2F1 mice exposed lethal total-body from cobalt-60 γ-ray source. 4100TPO (2...
Filgrastim (Neupogen®, granulocyte-colony stimulating factor) is among the few countermeasures recommended for management of patients in event lethal total-body irradiation. Despite plethora studies using filgrastim as a radiation countermeasure, relatively little known about optimal dose schedule to mitigate lethality. We evaluated efficacy improving 30-day survival CD2F1 mice irradiated with (LD70/30) AFRRI cobalt-60 facility. tested different schedules 1, 3, 5, 10 or 16 once-daily...
Abstract Akt has been implicated as a molecular determinant of cellular radiosensitivity. Because it is often constitutively activated or overexpressed in malignant gliomas, suggested target for brain tumor radiosensitization. To evaluate the role glioma radioresponse, we have determined effects perifosine, clinically relevant alkylphospholipid that inhibits activation, on radiosensitivity three human cell lines (U87, U251, and LN229). Each expressed clearly detectable levels phosphorylated...
Objective The objective of this study was to investigate the correlation between in vivo δ-tocotrienol (DT3) pharmacokinetics, pharmacodynamics and radiation protection, evaluate effect DT3 pre-treatment on radiation-induced alterations apoptotic autophagic pathways. Methods We evaluated pharmacokinetics (plasma, 0.5 12 h) (peripheral blood indices; day 3, 7, 10 14) after a single subcutaneous injection 300 mg kg−1 unirradiated CD2F1 mice. Next, we monitored 30-day post-irradiation survival...
Biomarkers are important indicators of biological processes in health or disease. For this reason, they play a critical role advanced development radiation biodosimetry tools and medical countermeasures (MCMs). They can aid the assessment exposure level, extent radiation-induced injury, and/or efficacy MCM. This meeting report summarizes presentations discussions from 2020 workshop titled, "Biomarkers Radiation Biodosimetry Medical Countermeasures" sponsored by Nuclear Countermeasures...
A B S T R C Orientin (Ot) and vicenin (Vc), two water soluble flavonoids isolated from the Indian Holy Basil, are potent radioprotectants, but mechanisms of protection not fully understood. In present study, we investigated effects these as antioxidants in chemical systems plasmid DNA radioprotectants bacterial mammalian cells. The radical scavenging activities Ot Vc were assessed systems, dipehnylpicrylhydrazyl (DPPH) 2,2´-azino-bis(3-thylbenz-thiazoline-6sulfonic acid) (ABTS) by estimating...
Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn Email Tools Get Permissions Cite Search Site Citation Yannick Poirier, Larry A. DeWerd, François Trompier, Morgane Dos Santos, Ke Sheng, Keith Kunugi, Merriline M. Satyamitra, Andrea L. DiCarlo, Thomas Winters; Minimum Reporting Standards Should be Expected for Preclinical Radiobiology Irradiators and Dosimetry in the Published Literature. Radiat Res 2023; doi:...
Abstract Bone marrow failure and hematopoietic damage is one of the major consequences irradiation-induced lethality. There an immediate need to develop medical countermeasures (MCMs) combat We tested efficacy CDX-301, developed by Celldex Therapeutics Inc., in mice exposed Co-60 gamma total body irradiation (TBI). The drug demonstrated its both as a prophylactic countermeasure mitigator CD2F1 TBI. A single dose CDX-301 administered 24 h prior post–exposure conferred significant survival....
Purpose The Sex Differences in Radiation Research workshop addressed the role of sex as a confounder radiation research and its implication real-world radiological nuclear applications.
The water-soluble vitamin E derivative alpha-TMG is an excellent radical scavenger. A dose of 600 mg/kg TMG significantly reduced radiation clastogenicity in mouse bone marrow when administered after irradiation. present study was aimed at investigating the radioprotective effect postirradiation treatment with against a range whole-body lethal (8.5-12 Gy) and sublethal (1-5 doses adult Swiss albino mice. Protection irradiation evaluated from 30-day survival assessed micronuclei chromosomal...
To address confounding issues that have been noted in planning and conducting studies to identify biomarkers of radiation injury, develop animal models simulate these injuries, test potential medical countermeasures mitigate/treat damage caused by exposure.
The Radiation and Nuclear Countermeasures Program within the National Institute of Allergy Infectious Diseases (NIAID), is tasked with mandate identifying biodosimetry tests to assess exposure medical countermeasures (MCMs) mitigate/treat injuries individuals exposed significant doses ionizing radiation from a radiological/nuclear incident, hosted. To fulfill this mandate, (RNCP), hosted workshop in 2018 entitled "Policies Regulatory Pathways U.S. FDA licensure: Biodosimetry Devices."...
Purpose: To study the protective effect of orientin and vicenin against early genomic effects foetal irradiation their late consequences in mice.Materials methods: Fourteen‐day pregnant mice were exposed to 1 Gy 60Co gamma‐radiation 30 min after an intraperitoneal injection or (50 µg kg−1 body weight). Chromosomal aberrations studied liver cells spleen colonies (three passages, colony‐forming units‐spleen CFU‐S1, CFU‐S2, CFU‐S3) 1–12 months post‐partum bone marrow. Peripheral blood counts...