A5024701843- Mosquito-borne diseases and control
- Neuroscience and Neuropharmacology Research
- Biomedical and Engineering Education
- Biosensors and Analytical Detection
- Metabolism and Genetic Disorders
- Reproductive Health and Contraception
- Photoacoustic and Ultrasonic Imaging
- Diet and metabolism studies
- Radiomics and Machine Learning in Medical Imaging
- Hormonal and reproductive studies
- Ovarian function and disorders
- Cervical Cancer and HPV Research
- Genetics, Bioinformatics, and Biomedical Research
- Viral Infections and Outbreaks Research
- Ectopic Pregnancy Diagnosis and Management
- Prostate Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Pregnancy and Medication Impact
- Cardiovascular Disease and Adiposity
- Herpesvirus Infections and Treatments
- Medical Imaging Techniques and Applications
- Viral Infections and Vectors
- Nanoplatforms for cancer theranostics
- Hepatitis B Virus Studies
- Prostate Cancer Treatment and Research
National Institutes of Health
1991-2024
National Cancer Institute
2010-2024
National Institute of Biomedical Imaging and Bioengineering
2016
King George's Medical University
1983-2012
Wythenshawe Hospital
2006
University of Manchester
2006
Global Virus Network
2000
Harvard University Press
1999-2000
Harvard University
1997-1999
Boston Children's Hospital
1997-1999
As COVID-19 continues, an increasing number of patients develop long COVID symptoms varying in severity that last for weeks, months, or longer. Symptoms commonly include lingering loss smell and taste, hearing loss, extreme fatigue, "brain fog." Still, persistent cardiovascular respiratory problems, muscle weakness, neurologic issues have also been documented. A major problem is the lack clear guidelines diagnosing COVID. Although some studies suggest due to prolonged inflammation after...
Summary: Purpose: Despite use of the ketogenic diet (KD) for >75 years its effectiveness or mechanism action has been examined in few animal studies. Using kindling model epilepsy, we tested anticonvulsant and behavioral consequences an experimental KD adult rats. Methods: Rats fully kindled from amygdala were divided into KD-fed standard rat diet-fed groups; treatment continued 5 weeks. The approximated at 4:l (“classic”) consisted (by weight) 70% fat, 14% protein, no carbohydrate,...
The purpose of this editorial is to provide a brief history National Institutes Health Cancer Institute (NCI) workshops as related quantitative imaging within the oncology setting. will then focus on recently supported NCI initiatives, including Quantitative Imaging Network (QIN) initiative and its organizational structure, planned research goals deliverables. publications in issue Translational Oncology come from many current members QIN network.
Summary: Purpose : The ketogenic diet (KD) is a high‐fat, low‐carbohydrate and ‐protein that has been used to treat refractory seizures in children for more than 75 years. However, little known about how the KD inhibits or its effects on epileptogenesis. Several animal models of epilepsy have responded favorably treatment, but not studied animals with genetic predisposition seizures. Here we antiepileptogenic effect EL mice, an model human idiopathic epilepsy. Methods Young male mice...
THE high fat, low carbohydrate, protein ketogenic diet (KD) has been used to control refractory epilepsy in children since 1920, although its mechanism of action is unknown. Previous animal studies have shown that the KD can increase acute seizure threshold, but effect on process epileptogenesis not studied. We tested an experimental adult rats using kainic acid (KA) model. P54 underwent KA-induced status epilepticus, followed by assignment a or consisting (by weight), 14% protein, 70% fat...
Choline is an essential nutrient for rats and humans, its availability during fetal development has long-lasting cognitive effects (Blusztajn, 1998). We investigated the of prenatal choline supplementation on memory deficits associated with status epilepticus. Pregnant received a control or choline-supplemented diet days 11-17 gestation. Male offspring [postnatal day 29 (P29)-32] were tested their ability to find platform in water maze before after administration convulsant dose pilocarpine...
SUMMARY Mean survival time following intracerebral inoculation of dengue virus was reduced and the titre in brain immunosuppressed mice markedly increased. A single dose cyclophosphamide given 24 h after i.c. or i.p. substantially number antibody forming cells spleen. Three doses virus, each followed by later, produced specific hyporesponsiveness to but not a heterologous (Coxsackie B4), with reduction spleen such animals against Coxsackie B4 virus. Adoptive immunity antiserum abolished...
SUMMARY Serum obtained from mice 3 to 5 weeks after the third i.p. dose of dengue type 2 virus (DV) protected recipient against intracerebral challenge with DV, whereas serum 1 and provided minimum protection. Adoptive intravenous transfer immune spleen cells immunization did not protect even a small (10 LD50) DV. Depletion T-cells by treatment anti-thymocyte potentiate DV infection. Development cell-mediated response (CMI) was noted only at two periods leucocyte migration inhibition test...
Point-of-care (POC) technologies have proved valuable in cancer detection, diagnosis, monitoring, and treatment the developed world, shown promise low-and-middle-income countries (LMIC) as well. Despite this promise, unique design constraints presented low-resource settings, coupled with variety of country-specific regulatory institutional dynamics, made it difficult for investigators to translate successful POC interventions LMIC markets. In response need, National Cancer Institute has...
Changes in enzymes and metabolites of the carbohydrate metabolism skeletal muscles were studied mice after intracerebral inoculation dengue type 2 virus. It was noted that lactic dehydrogenase, aldolase, phosphoglucoisomerase, phosphoglucomutase, GO-T GP-T activity enhanced initially by two- to three-fold, reaching a peak on day 5. As illness appeared mice, all enzyme activities lowered about three times less paralytic stage 8th as compared controls. Fructose-1,6-diphosphatase increased 4th...
The association of central obesity, hyperinsulinemia, and dyslipidemia with higher grade advanced prostate cancer as determined by Gleason grading is not well understood. We evaluated the effect obesity waist hip ratio (WHR ≥ 0.9) biochemical parameters associated on in North Indian patients presenting at stages.A cross-sectional study was conducted among 50 nondiabetic having clinical stages III IV cancer. core biopsy samples histopathology done were divided two groups-group1, score ≥8;...
On April 17, 2010, scientists from academia, the National Cancer Institute (NCI), and Food Drug Administration (FDA) assembled at "The NCI Image Guided Delivery Summit," in Washington D.C., to discuss recent advances, barriers, opportunities, regulatory issues related field. The meeting included a scientific session an NCI/FDA session, followed by panel discussion of speakers both sessions. Image-guided drug delivery (IGDD) cancer is form individualized therapy where imaging methods are used...
Aim: To determine whether the metabolic syndrome (MS) or its individual components is associated with radiologically determined prostate volume: an objective measure of benign prostatic hyperplasia (BPH). Methods: Between January 2008 and December 2009, a case–control study was conducted among 200 males aged over 50 years, attending urology clinic, patients diagnosed as having BPH being taken cases (Group 1), while healthy volunteers were control group from routine health camp organized by...
Abstract As nanotechnologies move closer to use in humans, quantitative imaging methods will play a vital role answering questions of biodistribution. Accurate knowledge the location and quantity vivo nanoconstructs carriers is challenging task, new at appropriate resolutions are being developed tested. Sustaining simultaneous advancement both development nanotechnology research requires multidisciplinary teams conducting experiments with interconnected goals. On an even greater scale,...