Nathan Mege
A5027562555- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Immune responses and vaccinations
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
- Immune Response and Inflammation
- Glycosylation and Glycoproteins Research
Drexel University
2023-2025
Reading Hospital
2023-2025
Abstract Herein, we studied the impact of empty LNP (eLNP), component mRNA-based vaccine, on anti-viral pathways and immune function cells from young aged individuals. eLNP induced maturation monocyte derived dendritic (MDDCs). We further show that upregulated CD40 cytokine production in multiple DC subsets monocytes. This coincided with phosphorylation TANK binding kinase 1 (pTBK1) interferon response factor 7 (pIRF7). In to eLNP, healthy older adults (>65 yrs) have decreased expression,...
Abstract The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the IgM N-glycosylation has not been studied viral infection. analysis from healthy controls hospitalized disease 2019 (COVID-19) patients reveals increased high-mannose sialylation that correlates with COVID-19 severity. These trends are confirmed within SARS-CoV-2-specific...
Age is a major risk factor for severe coronavirus disease 2019 (COVID-19), yet the mechanisms behind this relationship have remained incompletely understood. To address this, we evaluated impact of aging on host immune response in blood and upper airway, as well nasal microbiome prospective, multicenter cohort 1031 vaccine-naïve patients hospitalized COVID-19 between 18 96 years old. We performed mass cytometry, serum protein profiling, anti–severe acute respiratory syndrome 2 (SARS-CoV-2)...
Abstract The glycosylation of IgG plays a critical role during human SARS-CoV-2, activating immune cells and inducing cytokine production. However, the IgM N-glycosylation has not been studied acute viral infection in humans. In vitro evidence suggests that inhibits T cell proliferation alters complement activation rates. analysis from healthy controls hospitalized COVID-19 patients reveals mannosylation sialyation levels associate with severity. Specifically, we find increased di-...
Abstract Despite the overwhelming success of mRNA-based vaccine in protecting against SARS-CoV-2 infection and reducing disease severity hospitalization, little is known about role lipid nanoparticles (LNP) play initiating immune response. In this report we studied adjuvantive impact empty LNP with no mRNA cargo (eLNP) on anti-viral pathways function cells from young aged individuals. We found that eLNP induced maturation monocyte derived dendritic by measuring expression CD40, CD80, HLA-DR...