A5100634827- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- SARS-CoV-2 and COVID-19 Research
- Gestational Diabetes Research and Management
- MicroRNA in disease regulation
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Bipolar Disorder and Treatment
- Evolution and Genetic Dynamics
- Mesenchymal stem cell research
- Circular RNAs in diseases
- Ectopic Pregnancy Diagnosis and Management
- Functional Brain Connectivity Studies
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- vaccines and immunoinformatics approaches
- Radiomics and Machine Learning in Medical Imaging
- Extracellular vesicles in disease
- Suicide and Self-Harm Studies
- Colorectal Cancer Screening and Detection
- Fatty Acid Research and Health
- Maternal and fetal healthcare
- Immune responses and vaccinations
- Optical Imaging and Spectroscopy Techniques
- Tryptophan and brain disorders
Wuhan University
2007-2025
Renmin Hospital of Wuhan University
2021-2025
Microbiology Institute of Shaanxi
2024
Institute of Microbiology
2024
Chinese Academy of Sciences
2024
Jilin University
2011-2024
First Hospital of Jilin University
2011-2024
State Key Laboratory of Microbial Resources
2024
Beijing Institute of Genomics
2016
Wuhan University of Science and Technology
2013
The microglia cell transfer has been shown to play a protective role in ischemic stroke. Microglia cells may this nerve-protective via the promotion of angiogenesis. However, underlying mechanisms are largely unknown and need further investigation.The aim study was investigate pro-angiogenesis effects unpolarized, interleukin-4 (IL-4)-polarized or lipopolysaccharide (LPS)-polarized BV2 both vivo vitro. We also investigated potential these effects.BV2 were polarized using phosphate-buffered...
Since late 2019, COVID-19 has significantly impacted the world. Understanding evolution of SARS-CoV-2 is crucial for protecting against future infectious pathogens. In this study, we conducted a comprehensive chronological analysis by examining mutation prevalence from source countries VOCs: United Kingdom, India, Brazil, South Africa, plus two countries: States, Russia, utilizing genomic sequences GISAID. Our methodological approach involved large-scale sequence alignment using MAFFT,...
Objectives: The transient receptor potential vanilloid type 1 (TRPV1) is a factor that mediates glial cell response with effects on mitochondrial function. It may affect the occurrence and development of schizophrenia. aim this study to further explore schizophrenia biomarkers by analyzing TRPV1 oxidative stress in astrocyte-derived extracellular vesicles (ADEs) peripheral blood mononuclear cells (PBMCs). Methods: A case–control was conducted. Positive Negative Syndrome Scale Brief...
Abnormal trophoblast invasion is one of the onsets preeclampsia (PE). Studies found that integrin β1 (ITGB1) closely related to PE, but role ITGB1 in progression remained unclear. Therefore, we studied functional PE and its effects on trophoblast.ITGB1 expression placenta tissues was determined by quantitative real-time polymerase chain reaction (qRT-PCR). The transfection HTR-8/SVneo cells were analyzed qRT-PCR western blotting. After cell transfection, colony formation assay, flow...
Background: Cognitive dysfunction is a common clinical feature of mental disorders. A number functional near-infrared spectroscopy (fNIRS) studies have shown reduced prefrontal activation during the verbal fluency task (VFT) in schizophrenia (SZ) and major depressive disorder (MDD). However, no examined compared brain patterns Tower London (TOL), which another classic, high-sensitivity executive function testing tool, these two serious This study aimed to assess characteristics different...
Preeclampsia is a multi-system disorder involved in pregnancy without an effective treatment except delivery. The precise pathogenesis of this complicated still not completely understood. objective study to evaluate the alterations protein expression and phosphorylations that are important regulating placental cell function preterm term preeclampsia. Using Protein Pathway Array, 38 proteins tissues were found be differentially expressed between preeclampsia gestational age matched control,...
Abstract Accumulating evidence shows that impaired spiral artery remodeling, placental dysfunction, and insufficient trophoblast infiltration contribute to the etiology pathogenesis of pre-eclampsia (PE). circRNAs are a class endogenous non-coding RNAs implicated in many diseases, including PE. This study aims investigate role circRNA hsa_circ_0008726 regulating migration invasion extravillous cells. RNase R assay was performed confirm circ_0008726 circular transcript. The expression...
The development mechanism of endometriosis remains unknown. Water channel aquaporin-1 (AQP1) enhances water flux across cell membranes, which is highly expressed and associated with migration, metastasis angiogenesis in some human cancers. In this study, the role Wnt signaling pathway mediated by AQP1 was investigated, a bid to provide new therapeutic targets for endometriosis. Microarray expression profiles were screened acquired differentially genes related Mouse models established...
Abstract Background Dyslipidemia, a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), is influenced by genetic variations, particularly those in the low-density lipoprotein receptor (LDLR) gene. This study aimed to elucidate effects of LDLR polymorphisms on baseline serum lipid levels and therapeutic efficacy atorvastatin an adult Han population northern China with dyslipidemia. Methods In this study, 255 Chinese adults receiving therapy were examined followed up....
The aim of this study was to investigate the effects and mechanisms polyunsaturated fatty acids (PUFAs) lipoxin A4 (LXA4) on preeclampsia (PE). LXA4 level significantly reduced in PE rats. PUFA diet upregulated expressions lipoxygenase 12 (LOX12) 15 (LOX15) downregulated those cyclooxygenase-2, tumor necrosis factor-α (TNF-α), endoglin. Lipopolysaccharides could inhibit cell growth cause inflammatory response, while presence PUFAs inhibited response promoted LOX12, LOX15, LXA4....
Abstract A family history of dementia is associated with an increased risk developing Alzheimer's disease (AD) late in life (LOAD). This study marked the first attempt to assess familial contribution differences cognitive performance a large family-based group Chinese community. We enrolled 168 participants without from single pedigree 9 probable AD patients diagnosed after age 65. These were evaluated comprehensive neuropsychological battery, version Mini Mental State Examination, and...
Objective: The correlation of the degree hydronephrosis and computed tomography (CT) value calculi with efficacy ureteroscopic lithotripsy (URSL) in patients upper urinary tract infectious was explored. Methods: clinical data 152 on URSL Shanghai Baoshan District Wusong Central Hospital from November 2019 to 2021 were collected for retrospective analysis. All received CT examination before surgery. According therapeutic effect URSL, all divided into non-calculi group (NCG, n = 101) residual...
Abstract There is an urgent need for animal models of coronavirus disease 2019 to study immunopathogenesis and test therapeutic intervenes. In this study, we showed that NOD/SCID IL2rg –/– (NSG) mice engrafted with human lung (HL) tissue (NSG‐L mice) could be infected efficiently by severe acute respiratory syndrome 2 (SARS‐CoV‐2), live virus capable infecting Vero cells was found in the HL grafts multiple organs from NSG‐L mice. RNA‐Sequencing identified a series differentially expressed...
"Uterine rupture in a setting of past tubal isthmus laparoscopic resection with successful maternal outcome and live birth: A case report." Journal Obstetrics Gynaecology, 36(4), pp. 435–436
COVID-19 has had a significant impact on the world since late 2019. Through 3 years pandemic, people are getting immunity, but virus evolves. SARS-CoV-2 genome data is biggest infectious we ever seen, understanding evolution of can help us better understand how to protect from future emergency pathogen. In this study, performed chronological backtracking study based not only specific lineages, prevalence mutations in population, using genomic sequences shared via GISAID source countries...