A5102915325- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Nanoplatforms for cancer theranostics
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Particle accelerators and beam dynamics
- Speech and Audio Processing
- Music and Audio Processing
- Particle Accelerators and Free-Electron Lasers
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Speech Recognition and Synthesis
- Andrographolide Research and Applications
- Renal cell carcinoma treatment
- Intracranial Aneurysms: Treatment and Complications
- Adrenal and Paraganglionic Tumors
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Renal and Vascular Pathologies
- Venous Thromboembolism Diagnosis and Management
- Network Security and Intrusion Detection
- Nanoparticle-Based Drug Delivery
First Hospital of Jilin University
2014-2024
Jilin University
2015-2024
Nanjing University
2013-2024
Nanjing General Hospital of Nanjing Military Command
2013-2024
Beijing University of Technology
2023
Guangdong Ocean University
2023
Xi'an Aeronautical University
2020
Wuhan University
2016
First Bethune Hospital of Jilin University
2015
Jinan Infectious Disease Hospital
2015
Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with an undifferentiated status and generally poor prognosis, but basis for these characteristics remains unknown. In this study, we show that upregulation of Polycomb protein histone methyltransferase EZH2, which limits differentiation in many tissues, critical to maintain state prognostic NB by epigenetic repression multiple suppressor genes. We identified role EZH2 examining regulation CASZ1, a recently gene whose...
OBJECT.: Aneurysmal subarachnoid hemorrhage (SAH) causes devastating rates of mortality and morbidity. Accumulating studies indicate that early brain injury (EBI) greatly contributes to poor outcomes after SAH oxidative stress plays an important role in the development EBI following SAH. Astaxanthin (ATX), one most common carotenoids, has a powerful antioxidative property. However, potential ATX protecting against remains obscure. The goal this study was assess whether can attenuate...
Apoptosis has been proven to play a crucial role in early brain injury pathogenesis and represent target for the treatment of subarachnoid hemorrhage (SAH). Previously, we demonstrated that astaxanthin (ATX) administration markedly reduced neuronal apoptosis period after SAH. However, underlying molecular mechanisms remain obscure. In present study, tried investigate whether ATX is associated with phosphatidylinositol 3-kinase-Akt (PI3K/Akt) pathway, which can an important signaling...
Abstract Immunotherapy, one of the most promising antitumor strategies, is used to treat prostate cancer (PCa). However, owing immunosuppressive tumor microenvironment (TME), therapeutic effect immune response greatly weakened. Therefore, there an urgent need explore new methods enhance responses. In this study, a single‐atom nanozyme platform (Cu SA‐DOX@COD) that can trigger pyroptosis developed activate responses via gasdermin E (GSDME)‐dependent pathway. It triggered by catalyzing...
No AccessJournal of UrologyInvestigative Urology1 Feb 2015The Cistrome and Gene Signature Androgen Receptor Splice Variants in Castration Resistant Prostate Cancer Cells Ji Lu, Peter E. Lonergan, Lucas P. Nacusi, Liguo Wang, Lucy J. Schmidt, Zhifu Sun, Travis Van der Steen, Stephen A. Boorjian, Farhad Kosari, George Vasmatzis, G. Klee, Steven Balk, Haojie Huang, Chunxi Donald Tindall LuJi Lu Department Urology, First Hospital Jilin University, Changchun, People's Republic China Mayo Clinic,...
MYST1 (also known as hMOF), a member of the MYST family histone acetyltransferases (HATs) an epigenetic mark active genes, is mainly responsible for H4K16 acetylation in cells. Recent studies have shown that abnormal gene expression hMOF involved certain primary cancers. Here we examined involvement and renal cell carcinoma (RCC). Simultaneously, investigated correlation between clear RCC (ccRCC) biomarker carbohydrase IX (CA9) RCC. The frozen tissues lines materials, reverse transcription...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an effective chemotherapeutic agent that specifically impairs cancer cells while sparing normal cells; however, some develop resistance to TRAIL.Here, we identified Andrographolide, a diterpenoid lactone derived from traditional herbal medicine Andrographis paniculata, as ideal sensitizer for TRAIL overcome bladder cancer.Our results showed combination treatment of Andro and retarded growth, attenuated proliferation,...
Abstract The realm of cancer therapy has been profoundly altered with the emergence immune checkpoint blockade (ICB) therapy, providing improved survival prospects for many patients some cancers. However, challenge achieving efficient or sustained therapeutic benefits underscores critical imperative to optimize ICB strategies. This review elucidates pivotal role predictive biomarkers in optimizing precision deciphering intricate dynamics associated response heterogeneity. Furthermore, it...
An overwhelming amount of evidence has emerged suggesting that dysregulated microRNAs (miRNAs) play crucial roles in tumorigenesis.The study was to analyze tissue/serum miR-144 expression gastric cancer and then evaluate their potential predict the prognosis cancer.We examined levels tissues peripheral blood samples from 96 patients using real-time PCR. Then association between clinicopathological parameters determined.The were significantly down-regulated cancerous tissue serum patients....
Despite accumulating evidence suggesting a critical role of signal transducer and activator transcription 3 (STAT3) Survivin in human bladder cancer, the effects silencing these genes on proliferation T24 carcinoma cells remain unknown. Here, we investigated inhibitory STAT3 or vitro vivo growth cells. Small interfering RNA (siRNA) vectors targeting STAT3, Survivin, both were designed synthesized. The recombinant plasmid DNA constructs confirmed by sequencing. They then transiently...
Abstract Prostate cancer (PCa) is the most common male urogenital malignancy worldwide. Surgery, endocrine therapy, radiotherapy, and chemotherapy are main clinical management options for PCa. However, these three therapies each have limitations. For example, surgery not suitable advanced PCa patients with extensive metastases, radiotherapy causes serious side effects. Primary therapy promotes progression of hormone‐sensitive into castration‐resistant prostate cancer. Therefore, considering...
Purpose To evaluate the effectivity and safety of percutaneous nephrolithotomy (PCNL) in treatment solitary kidney with staghorn stones prone position or completely supine position. Materials methods We retrospectively reviewed records 18 patients a treated PCNL. 12 underwent PCNL (group A). 6 B). Demographic data, number accesses, operating time, stone free rate, hemoglobin values, hospital stay complications were studied. Serum creatinine, systolic diastolic blood pressure, new onset...
Numerous studies have proved that microRNAs (miRNAs) play crucial roles in the tumorigenesis and progression of gastric cancer (GC). Our study was to investigate correlation between miR-338-3p expression clinical features as well prognosis GC. A total 138 GC tissue specimens ad jacent non-cancerous tissues were collected for further analysis, then quantitative PCR method used detect relative expression. showed level greatly decreased compared with paired normal tissues. Furthermore, loss...
Nanoscale polymeric micelles have attracted more and attention as a promising nanocarrier for controlled delivery of antineoplastic drugs. Herein, the doxorubicin (DOX)-loaded poly(D-lactide)-based micelle (PDM/DOX), poly(L-lactide)-based (PLM/DOX), stereocomplex (SCM/DOX) from equimolar mixture enantiomeric four-armed poly(ethylene glycol)-polylactide (PEG-PLA) copolymers were successfully fabricated. In phosphate-buffered saline (PBS) at pH 7.4, SCM/DOX exhibited smallest hydrodynamic...