A5075734229- Plant and animal studies
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Marine and coastal plant biology
- Plant and Fungal Species Descriptions
- GABA and Rice Research
- Advanced MRI Techniques and Applications
- Insect and Pesticide Research
- Marine Biology and Ecology Research
- Renal and Vascular Pathologies
- Coastal wetland ecosystem dynamics
- MRI in cancer diagnosis
- Advanced Radiotherapy Techniques
- Genetic Mapping and Diversity in Plants and Animals
- Radiation Therapy and Dosimetry
- Plant Parasitism and Resistance
- Ecology and Vegetation Dynamics Studies
- Plant Diversity and Evolution
- Tissue Engineering and Regenerative Medicine
- Rice Cultivation and Yield Improvement
- Lepidoptera: Biology and Taxonomy
- Species Distribution and Climate Change
- Plant Reproductive Biology
- Diet, Metabolism, and Disease
- Plant biochemistry and biosynthesis
Shanghai Chenshan Plant Science Research Center
2017-2025
East China Normal University
2015-2025
University of Maryland, Baltimore
2021-2024
Center for Excellence in Molecular Plant Sciences
2024
Yichun University
2020-2024
Hubei University
2024
Jinggangshan University
2019-2023
South China Sea Institute Of Oceanology
2023
Shanghai Ocean University
2022-2023
Shanghai Botanical Garden
2023
The underlying cause of major cardiovascular events, such as myocardial infarctions and strokes, is atherosclerosis. For accurate diagnosis this inflammatory disease, molecular imaging required. Toward goal, we sought to develop a nanoparticle-based, high aspect ratio, molecularly targeted magnetic resonance (MR) contrast agent. Specifically, engineered the plant viral nanoparticle platform tobacco mosaic virus (TMV) target vascular cell adhesion molecule (VCAM)-1, which highly expressed on...
Abstract The gymnosperm Welwitschia mirabilis belongs to the ancient, enigmatic gnetophyte lineage. It is a unique desert plant with extreme longevity and two ever-elongating leaves. We present chromosome-level assembly of its genome (6.8 Gb/1 C) together methylome transcriptome data explore astonishing biology. also refined, high-quality Gnetum montanum enhance our understanding evolution. has been shaped by lineage-specific whole duplication (~86 million years ago) more recently (1-2...
Hepatocellular carcinoma (HCC) is the most major type of primary hepatic cancer. Serine hydroxymethyltransferase 1 (SHMT1) recently found to play critical roles in human cancers including lung cancer, ovarian cancer and intestinal However, expression, function underlying mechanisms SHMT1 HCC remain uncovered.qRT-PCR, immunohistochemistry immunoblotting were performed detect expression tissues cell lines. migration invasion determined by Boyden chamber Transwell assay vitro, tumor metastasis...
Global consumption of high-fat diets (HFD) is associated with an increased incidence cardiometabolic syndrome and cardiac injury, warranting identification cardioprotective strategies. Cardioprotective effects quercetin (Q) have mostly been evaluated in ischemic heart disease models attributed to senolysis. We hypothesized that Q could alleviate murine damage caused by HFD restoring the myocardial microcirculation. C57BL/6J mice were fed standard chow or for 6 months then treated (50 mg/kg)...
The ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\overline {{2}} {01}$ </tex-math></inline-formula> )-oriented Mg-doped notation="LaTeX">$\boldsymbol {\beta }$ - notation="LaTeX">${\text {Ga}}_{2}{\text {O}}_{3- \delta films were grown on (0001)-sapphire substrates by pulsed laser deposition (PLD) at various oxygen partial pressures notation="LaTeX">$\text{P}_{\text {O}}\,\,=10$ -40mTorr)....
Heat stress is a major restrictive factor that causes yield loss in rice. We previously reported the priming effect of abscisic acid (ABA) on rice for enhanced thermotolerance at germination, seedling and heading stages. In present study, we aimed to understand mechanism ABA grain filling capacity under heat stress.Rice plants were pretreated with distilled water, 50 μM 10 fluridone by leaf spraying 8 d or 15 after initial (AIH) stage then subjected conditions 38 °C day/30 night 7 days,...
Dipterocarpoideae species form the emergent layer of Asian rainforests. They are indicator for rainforest distribution, but they severely threatened. Here, to understand their adaptation and population decline, we assemble high-quality genomes seven including two autotetraploid species. We estimate divergence time between Malvaceae within be 108.2 (97.8‒118.2) 88.4 (77.7‒102.9) million years ago, identify a whole genome duplication event preceding dipterocarp lineage diversification. find...
Abstract Background The recent rediscovery of the FLASH effect, a normal tissue sparing phenomenon observed in ultra‐high dose rate (UHDR) irradiations, has instigated surge research endeavors aiming to close gap between experimental observation and clinical treatment. However, dependences effect its underpinning mechanisms on beam parameters are not well known, large‐scale vivo studies using murine models human cancer needed for these investigations. Purpose To commission high‐throughput,...
Abstract Closely related and co-distributed species usually share a common phylogeographic history, but it is still largely unclear whether ecologically interacting can respond synchronously to historical climate changes. Here, we focused on fig-pollinator mutualism comprising Ficus pumila var. its obligate pollinators (morphospecies Wiebesia pumilae), collected samples across most of their distribution ranges. We employed both cytoplasmic DNA sequences nuclear microsatellite loci reveal the...
ABSTRACT Aim Dispersal of plant propagules and their genes is crucial for responses to landscape heterogeneities, yet the mechanisms behind this dispersal remain unclear. Ficus species depend on wind‐borne fig wasps pollination, but research airflow effects genetic structure has produced conflicting results. Our study aims clarify role wind in shaping such plants with insect pollinators by examining how geomorphological complexity interacts air movements influence structures. Location...
Background
Abstract Mixed-lineage kinase domain-like protein (MLKL) is known as the terminal executor of necroptosis. However, its function outside necroptosis still not clear. Herein, we demonstrate that MLKL promotes vascular inflammation by regulating expression adhesion molecules ICAM1, VCAM1, and E-selectin in endothelial cells (EC). deficiency suppresses these molecules, thereby reducing EC-leukocyte interaction vitro vivo. Mechanistically, show interacts with RBM6 to promote mRNA stability...
Novel therapies are needed to address the increasing prevalence of chronic kidney disease. Mesenchymal stem/stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) augment tissue repair. We tested hypothesis that EVs as effective MSCs in protecting stenotic kidney, but target different injury pathways. Pigs were studied after 16 weeks renal achieved by diet-induced metabolic syndrome (MetS) artery stenosis (RAS). untreated or treated 4 earlier with intrarenal delivery autologous...
Purpose To develop and validate a method for measuring murine single‐kidney glomerular filtration rate (GFR) using dynamic contrast‐enhanced MRI (DCE‐MRI). Methods This prospective study was approved by the Institutional Animal Care Use Committee. A fast longitudinal relaxation time (T 1 ) measurement implemented to capture gadolinium dynamics (1 s/scan), modified two‐compartment model developed quantify GFR as well renal perfusion 16.4T in mice 2 weeks after unilateral artery stenosis (RAS,...
Humans exhibit broad heterogeneity in affiliative social behavior. Twin and family studies show that individual differences core dimensions of behavior are heritable, yet there knowledge gaps understanding the underlying genetic neurobiological mechanisms. Animal reference panels (GRPs) provide a tractable strategy for examining behavioral architecture complex traits. Here, using males from 50 mouse strains BXD GRP, 4 domains behavior-social approach, recognition, direct interaction (DSI)...
Heat stress (HS) has become a major factor limiting crop yields worldwide. HS inhibits plant growth by ROS accumulation, and NADPH oxidases (Rbohs) are producers in plants. Here, we show that CRISPR/Cas knockout of the OsRbohB (OsRbohB-KO) significantly increased rice tolerance to imposed at various different stages. We produced OsRbohB-KO OsRbohB-overexpression (OsRbohB-OE) lines japonica cultivar, Nipponbare. Compared with nontransgenic wild-type (WT) plants, showed significant increase...
Summary Temperate japonica / geng (GJ) rice yield has significantly improved due to intensive breeding efforts, dramatically enhancing global food security. However, little is known about the underlying genomic structural variations (SVs) responsible for this improvement. We compared 58 long‐read assemblies comprising cultivated and wild species in present study, revealing 156 319 SVs. The phylogenomic analysis based on SV dataset detected putatively selected region of GJ sub‐populations. A...
Background Ossabaw pigs are unique miniature swine with genetic predisposition to develop metabolic syndrome and coronary atherosclerosis after extended periods receiving atherogenic diets. We have hypothesized that transgenic expressing chimp PCSK9 (proprotein convertase subtilisin‐like/kexin type 9) containing the D374Y gain of function would familial hypercholesterolemia artery plaques more rapidly than Landrace same transgene. Methods Results gain‐of‐function founders were generated by...
A stamp-based printing technique was applied to transfer the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\beta $ </tex-math></inline-formula> -Ga notation="LaTeX">$_{{2}}\text{O}_{{3}}$ films grown by pulsed laser deposition (PLD) from Si substrates onto some flexible substrates, such as PET, PEN, and PI. It is demonstrated that -based solar-blind photodetectors (SBPDs) exhibit brilliant optoelectrical...
Background: Alcoholic liver disease (ALD) caused by chronic ethanol overconsumption is a common type of with severe mortality burden throughout the world. The pathogenesis ALD complex, and no effective clinical treatment for has advanced so far. Prolonged alcohol abstinence most therapy to attenuate course even reverse damage. However, molecular mechanisms involved in abstinence-improved recovery from alcoholic fatty remain unclear. This study aims systematically evaluate beneficial effect...
Chronic ischemia triggers senescence in renal tubules and at least partly mediates kidney dysfunction damage through a p16