A5101667525- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Inflammatory Biomarkers in Disease Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nanoparticle-Based Drug Delivery
- Protein Degradation and Inhibitors
- Microtubule and mitosis dynamics
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Inflammasome and immune disorders
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Hepatitis B Virus Studies
- Neurofibromatosis and Schwannoma Cases
- Chromatin Remodeling and Cancer
Zhejiang Provincial People's Hospital
2014-2024
Hangzhou Medical College
2018-2024
China Three Gorges University
2016-2024
Yichang Central People's Hospital
2024
Qinghai University
2015
Hebei University of Technology
2009
Sichuan University
2002-2005
Hepatocellular carcinoma (HCC) is the most major type of primary hepatic cancer. Serine hydroxymethyltransferase 1 (SHMT1) recently found to play critical roles in human cancers including lung cancer, ovarian cancer and intestinal However, expression, function underlying mechanisms SHMT1 HCC remain uncovered.qRT-PCR, immunohistochemistry immunoblotting were performed detect expression tissues cell lines. migration invasion determined by Boyden chamber Transwell assay vitro, tumor metastasis...
Abstract Ulcerative colitis (UC) is a chronic, recurrent inflammatory bowel disease. UC confronts with severe challenges including the unclear pathogenesis and lack of specific diagnostic markers, demanding for identifying predictive biomarkers diagnosis treatment. We perform immune infiltration weighted gene co-expression network analysis on expression profiles active UC, inactive normal controls to identify related cell hub genes. Neutrophils, M1 macrophages, activated dendritic cells,...
Resistance to chemotherapy drugs remains a significant problem for the treatment of many types cancer. Fascin‑1 (FSCN‑1) is an actin-bundling protein involved in invasion and metastasis variety tumors. However, its involvement drug resistance hepatocellular carcinoma (HCC) unclear. The present study aimed investigate function FSCN‑1 HCC doxorubicin (DOX). expression was increased DOX-resistant cell lines (SNU449 SNU387) compared with DOX-sensitive (Huh7 Hep3B). cells DOX decreased following...
Abstract Bromodomain-containing protein 9 (BRD9) has a critical role in human squamous cell lung cancer, acute myeloid leukemia, and malignant rhabdoid tumors. However, the expression biological of BRD9 hepatocellular carcinoma (HCC) is poorly understood. In this study, was found to be elevated HCC through data mining public databases. Next, we confirmed that increased tissues compared with adjacent non-tumor tissues. The upregulated level also observed cells comparison LO2 cells. correlated...
Abstract Cancer metastasis is the leading cause of mortality in patients with hepatocellular carcinoma (HCC). To meet rapid malignant growth and transformation, tumor cells dramatically increase consumption nutrients, such as amino acids. Peptide transporter 1 (PEPT1), a key for small peptides, has been found to be an effective energy‐saving intracellular source acids that are required cells. Here, role PEPT1 HCC its underlying mechanisms explored. upregulated tissues, high expression...
Pancreatic cancer (PC) represents one of the most aggressive forms cancer. The role long non-coding RNAs (lncRNAs) has been highlighted in various malignancies including PC. aim present study was to investigate effects associated with actin filament-associated protein 1 antisense RNA (AFAP1-AS1) on progression PC and underlying mechanism. Microarray-based gene expression profiling performed identify PC-related lncRNAs, after which AFAP1-AS1 stem cell (CSC) markers tissues cells were...
Early detection of a tumour remains an unmet medical need, and approaches with high sensitivity specificity are urgently required. Mass cytometry time-of-flight (CyTOF) is powerful technique to profile immune cells could be applied detection. We attempted establish diagnostic models for hepatocellular carcinoma (HCC) pancreatic ductal adenocarcinoma (PDAC).We performed CyTOF analysis 2348 participants from 15 centres, including 1131 hepatic diseases, 584 diseases 633 healthy volunteers....
Nutritional and inflammatory status has been reported to be associated with the prognosis of hepatocellular carcinoma (HCC), but many studies did not include all biomarkers simultaneously. The present study aimed determine impact Naples prognostic score (NPS) on long-term survival in patients undergoing hepatectomy for HCC.Patients HCC after curative resection were eligible. Then, stratified into three groups according NPS. Clinical features outcomes compared among groups. Independent...
The incidence of gastric cancer is high in Chinese Tibetan. This study aimed to identify the differentially expressed microRNAs (miRNAs) and further explore their potential roles Tibetan with so as predict therapeutic targets. A total 10 patients (male:female = 6:4) were enrolled for isolation matched adjacent non-cancerous tissue samples. Affymetrix GeneChip microRNA 3.0 Array was employed detection miRNA expression Differential analysis between two sample groups analyzed using Limma...
Background Sequential transarterial chemoembolization (TACE) and portal vein embolization (PVE) are associated with long time interval that can allow tumor growth nullify treatments' benefits. Aim To evaluate the effect of simultaneous TACE PVE for patients large hepatocellular carcinoma (HCC) prior to elective major hepatectomy. Methods Fifty-one HCC who underwent combined or without hepatectomy were included in this study, 13 + group, 17 sequential 21 PVE-only group. The outcomes...
Hepatocellular carcinoma (HCC) is a common malignant tumor of the digestive system, and its early asymptomatic characteristic increases difficulty diagnosis treatment. This study aimed at obtaining some novel biomarkers with diagnostic prognostic meaning may find out potential therapeutic targets for HCC. We screen differentially expressed genes (DEGs) from HCC gene expression profile GSE14520 using GEO2R. Gene Ontology (GO) analysis Kyoto Encyclopedia Genes Genomes (KEGG) enrichment were...
Although anatomical hepatectomy (AH) is widely used in the treatment of hepatocellular carcinoma (HCC), prognosis still unsatisfactory. The present study aimed to evaluate survival benefit adjuvant transcatheter arterial chemoembolization (TACE) for patients with HCC after AH.A total 832 were stratified into TACE (443, 53.2%) and without group (389, 46.8%) AH. Propensity score matching (PSM) was performed control confounding factors, multivariable Cox regression determine independent risk...
The impact of diabetes mellitus (DM) on the survival patients with hepatocellular carcinoma (HCC) is still unclear. present study aims to draw a firm conclusion in terms evaluating DM prognosis HCC after hepatectomy.The pattern recurrence for was often stratified into early-stage (<2 years) and late-stage (≥2 recurrence. Because mainly attributed aggressive tumor pathological characteristics, who or die within 2 years were excluded. Cumulative overall (OS) recurrence-free (RFS) determined by...
Hepatocellular carcinoma (HCC) is one of the most serious consequences chronic hepatitis B virus (HBV) or C (HCV) infection. This study sought to investigate long-term outcomes after liver resection for HCC among patients with HBV/HCV co-infection (HBV/HCV-HCC) compared HBV infection (HBV-HCC). Patients who underwent curative-intent were identified from a multicenter Chinese database. Using propensity score matching (PSM), HBV/HCV-HCC matched one-to-one HBV-HCC. Overall survival (OS) and...
with a disease-free survival of 1 year since the surgery.Hepatocellular carcinoma gastric invasion should be considered as rare cause upper gastrointestinal bleeding in hepatocellular patients, especially lesions located left lateral hepatic lobe.Surgery is best solution.
The benefit of postoperative adjuvant transcatheter arterial chemoembolization (pTACE) for patients with hepatocellular carcinoma (HCC), especially those Child-Pugh (CP) B, remains controversial. This study aimed to assess the survival pTACE HCC CP B.
Dendritic cell‑specific intercellular adhesion molecule‑grabbing non‑integrin‑related protein (DC‑SIGNR) is a transmembrane receptor primarily involved in pathogen recognition by the innate immune system, with particular importance for viral recognition. DC‑SIGNR may also be associated tumorigenesis. The aim of present study was to investigate association between expression, development hepatocellular carcinoma (HCC), and clinicopathological features. Immunohistochemistry used assess...
Background: Citron kinase (CIT) is a protein related to cytokinesis and an important abscission regulator. However, the relationship between CIT hepatocellular carcinoma (HCC) unclear. The aim of this study was investigate expression in HCC tissues, explore connection clinicopathological characteristics HCC. Methods: Immunohistochemistry staining on 235 tissues 96 non-tumorous liver controls performed examine expression. We then analyzed correlation parameters via χ2 tests, we overall...