Jiachen Li

ORCID: 0000-0003-2961-8210
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About
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Research Areas
  • Nanopore and Nanochannel Transport Studies
  • Graphene research and applications
  • Membrane Separation Technologies
  • Nanoparticle-Based Drug Delivery
  • Catalysis for Biomass Conversion
  • Antimicrobial Peptides and Activities
  • Carbon dioxide utilization in catalysis
  • Catalysts for Methane Reforming
  • Polymer Surface Interaction Studies
  • RNA Interference and Gene Delivery
  • Blood Coagulation and Thrombosis Mechanisms
  • Advanced Memory and Neural Computing
  • Advanced biosensing and bioanalysis techniques
  • Advanced Drug Delivery Systems
  • Graphene and Nanomaterials Applications
  • Antibiotic Resistance in Bacteria
  • Blood properties and coagulation
  • Mitochondrial Function and Pathology
  • Bone Tissue Engineering Materials
  • Transition Metal Oxide Nanomaterials
  • Advanced NMR Techniques and Applications
  • Amino Acid Enzymes and Metabolism
  • Dental Erosion and Treatment
  • Conducting polymers and applications
  • Membrane Separation and Gas Transport

Tianjin University
2025

Nanjing Agricultural University
2025

Hebei Medical University
2025

Hebei University
2025

Institute of Physics
2025

Jilin University of Finance and Economics
2025

Beijing Chao-Yang Hospital
2024

Capital Medical University
2024

Zhejiang University
2019-2024

University of California, Berkeley
2024

The successful implementation of thin-film composite membranes (TFCM) for challenging solute-solute separations in the pharmaceutical industry requires a fine control over microstructure (size, distribution, and connectivity free-volume elements) thickness selective layer. For example, desalinating antibiotic streams highly interconnected elements right size to block antibiotics but allow passage salt ions water. Here, we introduce stevioside, plant-derived contorted glycoside, as promising...

10.1126/sciadv.adg6134 article EN cc-by-nc Science Advances 2023-05-05

Rapid biomimetic intrafibrillar mineralization of collagen was induced by polyelectrolyte–calcium complexes as a pre-precursor.

10.1039/d0nr05640e article EN Nanoscale 2020-12-09

Abstract Dentin hypersensitivity (DH) is triggered by external stimuli irking fluid flow through exposed dentinal tubules (DTs). Three commercially available desensitizing agents as control in this study only achieve limited occlusion depths of ≈10 µm the DTs well scarce remineralization demineralized dentin matrix. Herein, polyelectrolyte‐calcium complexes pre‐precursor (PCCP) process proposed for managing DH that with rubbed ultrahighly concentrated suspension (4 g L −1 ‐5.44 m ) followed...

10.1002/adhm.202300100 article EN Advanced Healthcare Materials 2023-03-17

The emerging and global spread of a novel plasmid-mediated colistin resistance gene, mcr-1 , threatens human health. Expression the MCR-1 protein affects bacterial fitness this cost correlates with lipid A perturbation. However, exact molecular mechanism remains unclear. Here, we identified M6 variant carrying two-point mutations that conferred co-resistance to β-lactam antibiotics. Compared wild-type (WT) MCR-1, caused severe disturbance in A, resulting up-regulation L, D-transpeptidases...

10.1371/journal.pbio.3002433 article EN cc-by PLoS Biology 2023-12-13

Abstract Human multidrug resistance protein 5 (hMRP5) effluxes anticancer and antivirus drugs, driving resistance. To uncover the mechanism of hMRP5, we determine six distinct cryo-EM structures, revealing an autoinhibitory N-terminal peptide that must dissociate to permit subsequent substrate recruitment. Guided by these molecular insights, design inhibitory could block entry into transport pathway. We also identify a regulatory motif, comprising positively charged cluster hydrophobic...

10.1038/s41467-024-49204-1 article EN cc-by Nature Communications 2024-06-06

This study aims to analyze the influence of weather index insurance on farmers' credit default rates loan group in trust games. A field economic experiment was conducted with 324 farmers Heilongjiang Province, China. The results indicate that reduces and improves efficiency after mitigating natural risk. Trust between is an important factor affecting their rates. acts as a mediating variable, reinforcing effect In order reduce defaults by risks for financial institutions, government should...

10.1080/08941920.2024.2449055 article EN Society & Natural Resources 2025-01-13

Fatty acid (FA) biosynthesis is a crucial cellular process that converts nutrients into metabolic intermediates necessary for membrane biosynthesis, energy storage, and the production of signaling molecules. Acetyl-CoA carboxylase (ACACA) plays pivotal catalytic role in both fatty synthesis oxidation. This cytosolic enzyme catalyzes carboxylation acetyl-CoA to malonyl-CoA, which represents first rate-limiting step de novo biosynthesis. In this study, we developed rapid effective purification...

10.21769/bioprotoc.5221 article EN cc-by-nc BIO-PROTOCOL 2025-01-01

In traditional finance theory, the Capital Asset Pricing Model (CAPM) has long been dominant theory for asset valuation. However, exist and prevalent of irrational investment behaviors in real-world markets lead to deviations between CAPM predicted prices actual prices, which raising doubts about accuracy CAPM. To solve this contradiction, Behavioral challenges Hypothesis Rational Man Efficient Markets by studying existing anomalies, thereby figure out flaw This paper will summarize explain...

10.54254/2754-1169/2025.22774 article EN Advances in Economics Management and Political Sciences 2025-05-15

Development of energy-efficient and low-cost desalination techniques is pivotal importance, reverse osmosis (RO) regarded as one the most promising solutions to tackle world water crisis has been widely deployed for large-scale distributed desalination. Graphene with nanopores was considered a membrane due its unique properties. However, intrinsic complexity process, together various tunable properties membranes/nanopores themselves, makes accurate prediction performance or designing new...

10.1021/acs.jpcc.1c09470 article EN The Journal of Physical Chemistry C 2021-12-08

Abstract For first-order phase transitions, the second derivatives of Gibbs free energy (specific heat and compressibility) diverge at transition point, resulting in an effect known as super-elasticity along pressure axis, or super-thermicity temperature axis. Here we report a chemical analogy these singularity effects atomic doping where derivative (chemical susceptibility) diverges leading to anomalously high barrier for dopant diffusion co-existing phases, coin super-susceptibility. The...

10.1038/s41467-024-50213-3 article EN cc-by Nature Communications 2024-07-10

Methanol synthesized from carbonate hydrogenation is of great importance for CO2 utilization indirectly. Herein, a series Cu/Zn/Al heterogeneous catalysts were prepared by co-precipitation with synchronous aging step, and applied diethyl (DEC) to produce methanol. Furthermore, the characterized physicochemical methods, such as N2 adsorption, ICP-OES, N2O titration, SEM, TEM, XRD, H2-TPR XPS in detail. Higher copper concentration led higher ratio bulk CuOx species calcined samples, which...

10.1039/d0ra00347f article EN cc-by-nc RSC Advances 2020-01-01
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