A5100746639- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Immune cells in cancer
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Advanced Memory and Neural Computing
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Methane Hydrates and Related Phenomena
- Energy Harvesting in Wireless Networks
- Epigenetics and DNA Methylation
- Thermography and Photoacoustic Techniques
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- Welding Techniques and Residual Stresses
- Hydrocarbon exploration and reservoir analysis
- Non-Destructive Testing Techniques
- Inflammatory Biomarkers in Disease Prognosis
- CCD and CMOS Imaging Sensors
- Cancer, Stress, Anesthesia, and Immune Response
- Atmospheric and Environmental Gas Dynamics
- Inflammasome and immune disorders
Guangzhou Marine Geological Survey
2023-2025
China Geological Survey
2023-2025
Anhui University of Science and Technology
2020-2025
Zhejiang University
2022-2025
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2022-2025
Southern Medical University
2022-2024
Hangzhou Normal University
2023-2024
Hangzhou Dianzi University
2022-2024
Nanfang Hospital
2022-2024
Second Xiangya Hospital of Central South University
2024
Abstract Background Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) is one of the causes tumor immune tolerance and failure cancer immunotherapy. Here, we found that bladder (BCa)-derived exosomal circRNA_0013936 could enhance immunosuppressive activity PMN-MDSCs by regulating expression fatty acid transporter protein 2 (FATP2) receptor-interacting kinase 3 (RIPK3). However, underlying mechanism remains largely unknown. Methods BCa-derived exosomes was isolated used for a...
Abstract Ferroptosis is closely linked to various cancers, including lung adenocarcinoma (LUAD); however, the factors involved in regulation of ferroptosis-related genes are not well established. In this study, we identified and characterized long noncoding RNAs (lncRNAs) LUAD. particular, a coexpression network mRNAs lncRNAs from The Cancer Genome Atlas (TCGA) was constructed. Univariate multivariate Cox proportional hazards analyses were performed establish prognostic lncRNA signature...
In this multicenter, single-arm phase 2 trial (ChiCTR1900024428), patients with locally advanced gastric/gastroesophageal junction cancers receive one cycle of sintilimab (anti-PD1) and chemotherapy (S-1 nab-paclitaxel), followed by 5 weeks concurrent chemoradiotherapy sintilimab, another thereafter. Surgery is preferably scheduled within to three weeks, cycles adjuvant are administrated. The primary endpoint the pathological complete response. Our results meet pre-specified endpoint....
Abstract Background Regulatory B cells (Bregs), a specialized subset of that modulate immune responses and maintain tolerance in malignant tumors, have not been extensively investigated the context bladder cancer (BLCA). This study aims to elucidate roles Bregs Breg-related genes BLCA. Methods We assessed Breg infiltration levels 34 pairs BLCA corresponding paracancerous tissues using immunohistochemical staining. conducted transwell wound healing assays evaluate impact on phenotype SW780...
ABSTRACT Hot water injection has been a simple and promising method of thermally stimulating the extraction hydrates, which promotes dissociation natural gas hydrates improves production. However, temperature region influenced by injecting hot requires further research evaluation. In this study, computational model field in hydrate reservoir during with finite volume method, considering coupled gas–liquid two‐phase flow, heat conduction, dissociation, was developed. The focuses on vertical...
Abstract Background The occurrence of epithelial-mesenchymal transition (EMT) and immune evasion is considered to contribute poor prognosis in lung adenocarcinoma (LUAD). Therefore, this study aims explore the key oncogenes that promote EMT reveal expression patterns, prognostic value, potential biological functions. Methods Firstly, we identified gene modules associated with Tumor Immune Dysfunction Exclusion (TIDE) through weighted co-expression network analysis (WGCNA). Next, utilized...
Oxalate is an organic dicarboxylic acid that a common component of plant foods. The kidneys are essential organs for oxalate excretion, but excessive oxalates may induce kidney stones. Jupiter microtubule associated homolog 2 (JPT2) critical molecule in Ca2+ mobilization, and its intrinsic mechanism exposure stones remains unclear. This study aimed to reveal the JPT2 Genetic approaches were used control expression cells mice, action was analyzed using transcriptomics untargeted metabolomics....
Abstract Background Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment of lung adenocarcinoma (LUAD) and are often associated with poorer clinical outcomes. This study aimed to screen for CAF-specific genes that could serve as promising therapeutic targets LUAD. Methods We established single-cell transcriptional profile LUAD, focusing on genetic changes fibroblasts. Next, we identified key through weighted gene co-expression network analysis (WGCNA)...
Prostate cancer (PCa) is one of the most common tumors affecting men all over world. PCa has brought a huge health burden to around world, especially for elderly men, but its pathogenesis unclear. In prostate cancer, epigenetic inheritance plays an important role in development, progression, and metastasis disease. An invasion played by matrix metalloproteinases (MMPs), zinc-dependent proteases that break down extracellular matrix. We review two forms modification tumor regulation, both...
(1) Background: The association between metabolic obesity phenotypes and incident lung cancer (LC) remains unclear. (2) Methods: Based on the combination of baseline BMI categories health status, participants were categorized into eight groups: metabolically healthy underweight (MHUW), unhealthy (MUUW), normal (MHN), (MUN), overweight (MHOW), (MUOW), (MHO), (MUO). Cox proportional hazards model Mendelian randomization (MR) applied to assess with LC risk. (3) Results: During a median...
Non-obstructive azoospermia (NOA) is a severe form of male infertility, but its pathological mechanisms and diagnostic biomarkers remain obscure. Since the dysregulation RNA-binding proteins (RBPs) had nonnegligible effects on spermatogenesis, we aimed to investigate functions diagnosis values RBPs in NOA. 58 testicular samples (control = 11, NOA 47) from Gene Expression Omnibus (GEO) were set as training cohort. Three public datasets, containing GSE45885 4, 27), GSE45887 16), GSE145467 10,...
Background: The development of human tumors is associated with the abnormal expression various functional genes, and tumor based massive database needs to be deeply mined. Based on multigene prediction model urgent access prognosis patients. Materials Methods: We selected three RNA profiles (GSE32863, GSE10072, GSE43458) from LUAD Gene Expression Omnibus (GEO) analyzed differentially expressed genes (DEGs) between normal tissue using GEO2R program. After that, we transcriptome data 479...
To investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) of patients with non-small cell lung cancer (NSCLC) and their risk developing brain metastases after adjusting for confounding factors.A retrospective observational study general data NSCLC diagnosed from January 2016 to December 2020. Multivariate logistic regression was used calculate dominance (OR) 95% confidence interval (CI) NLR subgroup analysis. Generalized summation models smoothed curve fitting were...
Abstract Hepatocellular carcinoma (HCC) does not respond well to current treatments, even immune checkpoint inhibitors. PD‐L1 (programmed cell death ligand 1 or CD274 molecule)‐mediated escape of tumor cells may be a key factor affecting the efficacy inhibitor (ICI) therapy. However, regulatory mechanisms expression and require further exploration. Here, we observed that DDX1 (DEAD‐box helicase 1) was overexpressed in HCC tissues associated with poor prognosis patients HCC. Additionally,...