A5069119621- Bone Metabolism and Diseases
- Bone health and treatments
- Metabolism, Diabetes, and Cancer
- Plant Stress Responses and Tolerance
- Hippo pathway signaling and YAP/TAZ
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Adipose Tissue and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Reproductive System and Pregnancy
- Ion channel regulation and function
- TGF-β signaling in diseases
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Analytical Chemistry and Chromatography
- Cancer-related gene regulation
- Complex Network Analysis Techniques
- Advanced Chemical Sensor Technologies
- Opinion Dynamics and Social Influence
- Metabolomics and Mass Spectrometry Studies
- Apelin-related biomedical research
Children's Hospital of Philadelphia
2020-2025
Huazhong University of Science and Technology
2013-2025
Tongji Hospital
2016-2025
Translational Therapeutics (United States)
2024
Ben-Gurion University of the Negev
2020-2024
China Agricultural University
2024
Renmin Hospital of Wuhan University
2023-2024
Wuhan University
2023-2024
Zhongshan Hospital
2024
Fudan University
2024
The development of lipid nanoparticle (LNP) formulations for targeting the bone microenvironment holds significant potential nucleic acid therapeutic applications including regeneration, cancer, and hematopoietic stem cell therapies. However, delivery to remains a challenge due several biological barriers, such as low blood flow in bone, blood–bone marrow affinity between drugs minerals, which leads unfavorable dosages microenvironment. Here, we construct series bisphosphonate (BP)...
Influence maximization is to extract a small set of nodes from social network which influences the propagation maximally under cascade model. In this paper, we propose memetic algorithm for community-based influence in networks. The proposed optimizes 2-hop spread find most influential nodes. Problem-specific population initialization and similarity-based local search are designed accelerate convergence algorithm. Experiments on three realworld datasets demonstrate that our has competitive...
Excessive bone resorption over formation is the root cause for loss leading to osteoporotic fractures. Development of new antiresorptive therapies calls a holistic understanding osteoclast differentiation and function. Although much has been learned about molecular regulation biology, little known metabolic requirement bioenergetics during osteoclastogenesis. Here, we report that glucose metabolism through oxidative phosphorylation (OXPHOS) predominant bioenergetic pathway support...
Intervertebral disc (IVD) degeneration is a frequent cause of low back pain and the most common disability. Treatments for symptomatic IVD degeneration, including conservative treatments such as analgesics, physical therapy, anti-inflammatories surgeries, are aimed at alleviating neurological symptoms. However, there no effective to prevent or delay degeneration. Previous studies have identified risk factors aging, inflammation, genetic factors, mechanical overload, nutrient deprivation...
Osteoarthritis (OA) is the leading joint disease characterized by cartilage destruction and loss of mobility. Accumulating evidence indicates that incidence severity OA increases with diabetes, implicating systemic glucose metabolism in health. However, a definitive link between cellular articular pathogenesis not yet established. Here, we report mice surgically induced to develop knee through destabilization medial meniscus (DMM), expression main transporter Glut1 notably reduced cartilage....
Skeletal fragility is associated with type 2 diabetes mellitus (T2D), but the underlying mechanism not well understood. Here, in a mouse model for youth-onset T2D, we show that both trabecular and cortical bone mass reduced due to diminished osteoblast activity. Stable isotope tracing vivo 13 C-glucose demonstrates glycolysis glucose fueling of TCA cycle are impaired diabetic bones. Similarly, Seahorse assays suppression oxidative phosphorylation by marrow mesenchymal cells as whole, whereas...
One of the ways Aflatoxin B1 damages liver is through ferroptosis. Ferroptosis characterized by build-up lipid peroxides and reactive oxygen species (ROS) due to an excess iron. Dietary supplements have emerged as a promising strategy for treating ferroptosis in liver. The flavonoid component hesperetin, which mostly present citrus fruits, has number pharmacological actions, such those against fibrosis, cancer, hyperglycemia. However, hesperetin's effects mechanisms hepatic are still...
Protein arginine methyltransferase 5 (PRMT5) is an methylation that regulates various physiological processes. Abnormal PRMT5 activity has been reported in inflammation and types of cancers. Because osteoclast differentiation characterized by the activation inflammation-related pathways, we speculated may play a role this process. In present study, found was upregulated during differentiation. Knockdown with siRNA bone marrow mononuclear cells (BMMs) resulted inhibition receptor activator...
Puccinia striiformis f. sp. tritici (Pst) secretes an array of specific effector proteins to manipulate host immunity and promote pathogen colonization. In a previous study, we functionally characterized glycine-serine-rich PstGSRE1 with motif (m9). However, the mechanisms effectors (GSREs) remain obscure. Here report new effector, PstGSRE4, which has no m9-like but inhibits enzyme activity wheat copper zinc superoxide dismutase TaCZSOD2, acts as positive regulator resistance Pst. By...
The initial interzone cells for synovial joints originate from chondrocytes, but such critical transition is minimally understood. With single-cell RNA sequencing (scRNA-seq) of murine embryonic knee joint primordia, we discovered that heightened expression glycolysis genes characterized developing when compared to flanking chondrocytes. Conditional deletion the glucose transporters Glut1 and/or Glut3, in either incipient pre-skeletal mesenchyme with Prx1Cre or chondrocytes Col2Cre,...
Low back pain (LBP) is a common worldwide disease that causes an enormous social economic burden. Intervertebral disc degeneration (IDD) considered as major cause of LBP. The process IDD complicated and involves both inflammation senescence. production pro-inflammatory cytokines, including tumor necrosis factor (TNF)α interleukin (IL)-1β, increased in the degenerating intervertebral disc, inducing extracellular matrix degradation. Urolithin A (UA) metabolite compound resulting from...
REV-ERBs (REV-ERBα and REV-ERBβ) are transcription repressors circadian regulators. Previous investigations have shown that repress the expression of target genes, including MMP9 CX3CR1, in macrophages. Because CX3CR1 reportedly participate receptor activator nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis, we inferred might play a role osteoclastogenesis. In present study, found REV-ERBα level decreased significantly during RANKL-induced osteoclast differentiation from primary...
Osteosarcoma (OS) is the most common primary bone tumor, whose poor prognosis mainly due to lung metastasis.The aim of this study build a practical and valid diagnostic test that can predict risk OS metastasis progression.We performed weighted gene co-expression network analysis (WGCNA) on GSE21257 from Gene Expression Omnibus (GEO) database, which contains microarray data biopsies patients.In these modules, highest association was found between blue module stage (r = -0.52)by Pearson's...
Bone homeostasis is maintained by osteoclast-mediated bone resorption and osteoblast-mediated formation. A dramatic decrease in estrogen levels postmenopausal women leads to osteoclast overactivation, impaired homeostasis, subsequent loss. Changes the gut microbiome affect mineral density. However, role of deficiency-induced loss its underlying mechanism remain unknown. In this study, we found that abundance Clostridium sporogenes (C. spor.) derived metabolite, indole propionic acid (IPA),...
Osteoclasts specialize in bone resorption and are critical for remodeling. Previous studies have shown that osteoclasts possess abundant mitochondria derive most energy through oxidative phosphorylation (OXPHOS). However, the substrates fueling OXPHOS remain to be fully defined. Here, we showed osteoclast differentiation was coupled with increased oxidation of glucose, glutamine, oleate. Transcriptomic analyses RNA sequencing revealed marked upregulation genes participating mitochondrial...
Bone metastasis is a severe complication associated with various carcinomas. It causes debilitating pain and pathologic fractures dramatically impairs patients' quality of life. Drugs aimed at osteoclast formation significantly reduce the incidence skeletal complications are currently standard treatment for patients bone metastases. Here, we reported that serum- glucocorticoid-inducible kinase 1 (SGK1) plays pivotal role in function osteoclasts by regulating Ca